SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BTN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE
(Aquifex
aeolicus) 		5 / 10 ALA A  28
SER A  13
LEU A   8
ALA A  31
ILE A   6
 None
BTN  A2001 (-2.7A)
None
None
None
 1.21A 1g5yC-3efsA:
undetectable		 1g5yC-3efsA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4dve BIOTIN TRANSPORTER
BIOY
(Lactococcus
lactis) 		3 / 4 VAL A 133
TRP A 140
TRP A  96
 None
None
BTN  A 201 ( 4.8A)
 1.31A 1gmkA-4dveA:
undetectable
1gmkB-4dveA:
undetectable		 1gmkA-4dveA:
14.46
1gmkB-4dveA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 4dve BIOTIN TRANSPORTER
BIOY
(Lactococcus
lactis) 		3 / 4 VAL A 133
TRP A 140
TRP A  96
 None
None
BTN  A 201 ( 4.8A)
 1.18A 1gmkC-4dveA:
undetectable
1gmkD-4dveA:
undetectable		 1gmkC-4dveA:
14.46
1gmkD-4dveA:
14.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE
(Aquifex
aeolicus) 		4 / 7 ARG A  43
TRP A  45
ASN A 123
ALA A 137
 ATP  A1001 (-2.9A)
BTN  A2001 ( 3.7A)
ATP  A1001 (-2.8A)
ATP  A1001 (-3.4A)
 0.73A 2ejfA-3efsA:
28.0		 2ejfA-3efsA:
34.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE
(Aquifex
aeolicus) 		4 / 6 ARG A  43
TRP A  45
ASN A 123
ALA A 137
 ATP  A1001 (-2.9A)
BTN  A2001 ( 3.7A)
ATP  A1001 (-2.8A)
ATP  A1001 (-3.4A)
 0.42A 2ejfB-3efsA:
28.5		 2ejfB-3efsA:
34.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		4 / 7 TRP A  45
LYS A 106
ASN A 126
ALA A 139
 BTN  A1301 (-3.9A)
BTN  A1301 (-2.6A)
None
None
 0.32A 2ejgA-2ej9A:
26.0		 2ejgA-2ej9A:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE
(Aquifex
aeolicus) 		5 / 7 ARG A  43
TRP A  45
LYS A 103
ASN A 123
ALA A 137
 ATP  A1001 (-2.9A)
BTN  A2001 ( 3.7A)
ATP  A1001 ( 3.1A)
ATP  A1001 (-2.8A)
ATP  A1001 (-3.4A)
 0.75A 2ejgA-3efsA:
28.0		 2ejgA-3efsA:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		4 / 7 TRP A  45
LYS A 106
ASN A 126
ALA A 139
 BTN  A1301 (-3.9A)
BTN  A1301 (-2.6A)
None
None
 0.48A 2ejgB-2ej9A:
26.1		 2ejgB-2ej9A:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE
(Aquifex
aeolicus) 		4 / 7 TRP A  45
LYS A 103
ASN A 123
ALA A 137
 BTN  A2001 ( 3.7A)
ATP  A1001 ( 3.1A)
ATP  A1001 (-2.8A)
ATP  A1001 (-3.4A)
 0.52A 2ejgB-3efsA:
28.1		 2ejgB-3efsA:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 1wbi AVIDIN-RELATED
PROTEIN 2
(Gallus
gallus) 		6 / 7 ASN A  12
LEU A  14
SER A  16
TYR A  33
THR A  35
VAL A  37
 BTN  A1001 (-3.3A)
BTN  A1001 ( 4.8A)
BTN  A1001 (-2.7A)
BTN  A1001 (-4.6A)
BTN  A1001 (-3.8A)
BTN  A1001 (-4.9A)
 0.36A 2uz2A-1wbiA:
20.4		 2uz2A-1wbiA:
48.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 1wbi AVIDIN-RELATED
PROTEIN 2
(Gallus
gallus) 		5 / 7 ASN A 116
LEU A  14
TYR A  33
THR A  35
VAL A  37
 BTN  A1001 (-3.4A)
BTN  A1001 ( 4.8A)
BTN  A1001 (-4.6A)
BTN  A1001 (-3.8A)
BTN  A1001 (-4.9A)
 1.05A 2uz2A-1wbiA:
20.4		 2uz2A-1wbiA:
48.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2c1q BIOTIN BINDING
PROTEIN A
(Gallus
gallus) 		6 / 7 ASN A  12
LEU A  14
SER A  16
TYR A  33
THR A  35
VAL A  37
 BTN  A1126 (-3.3A)
BTN  A1126 (-4.8A)
BTN  A1126 (-2.6A)
BTN  A1126 (-4.5A)
BTN  A1126 (-3.6A)
None
 0.29A 2uz2A-2c1qA:
20.1		 2uz2A-2c1qA:
49.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2c1q BIOTIN BINDING
PROTEIN A
(Gallus
gallus) 		5 / 7 ASN A 119
LEU A  14
TYR A  33
THR A  35
VAL A  37
 BTN  A1126 (-3.2A)
BTN  A1126 (-4.8A)
BTN  A1126 (-4.5A)
BTN  A1126 (-3.6A)
None
 1.17A 2uz2A-2c1qA:
20.1		 2uz2A-2c1qA:
49.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		5 / 7 ASN A  63
LEU A  93
TYR A 112
THR A 114
VAL A 116
 BTN  A1274 (-3.2A)
BTN  A1274 ( 4.9A)
BTN  A1274 (-4.5A)
BTN  A1274 (-3.7A)
BTN  A1274 (-4.9A)
 1.10A 2uz2A-2c4iA:
4.7		 2uz2A-2c4iA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		6 / 7 ASN A  91
LEU A  93
SER A  95
TYR A 112
THR A 114
VAL A 116
 BTN  A1274 (-3.3A)
BTN  A1274 ( 4.9A)
BTN  A1274 (-2.7A)
BTN  A1274 (-4.5A)
BTN  A1274 (-3.7A)
BTN  A1274 (-4.9A)
 0.36A 2uz2A-2c4iA:
4.7		 2uz2A-2c4iA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		5 / 7 ASN A 184
LEU A 214
TYR A 233
THR A 235
VAL A 237
 BTN  A1275 (-3.2A)
BTN  A1275 (-4.8A)
BTN  A1275 (-4.6A)
BTN  A1275 (-3.7A)
BTN  A1275 (-4.8A)
 1.10A 2uz2A-2c4iA:
4.7		 2uz2A-2c4iA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		6 / 7 ASN A 212
LEU A 214
SER A 216
TYR A 233
THR A 235
VAL A 237
 BTN  A1275 (-3.2A)
BTN  A1275 (-4.8A)
BTN  A1275 (-2.6A)
BTN  A1275 (-4.6A)
BTN  A1275 (-3.7A)
BTN  A1275 (-4.8A)
 0.36A 2uz2A-2c4iA:
4.7		 2uz2A-2c4iA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2jgs CIRCULAR PERMUTANT
OF AVIDIN
(Gallus
gallus) 		6 / 7 ASN A 104
LEU A 106
SER A 108
TYR A 125
THR A 127
VAL A 129
 BTN  A1001 ( 4.4A)
None
BTN  A1001 (-2.6A)
BTN  A1001 (-4.5A)
BTN  A1001 (-3.7A)
None
 0.37A 2uz2A-2jgsA:
undetectable		 2uz2A-2jgsA:
35.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2zsc TAMAVIDIN2
(Pleurotus
cornucopiae) 		6 / 7 ASN A  14
LEU A  16
SER A  18
TYR A  34
VAL A  38
TRP A  80
 BTN  A 301 (-3.4A)
BTN  A 301 ( 4.9A)
BTN  A 301 (-2.6A)
BTN  A 301 (-4.5A)
BTN  A 301 (-4.8A)
BTN  A 301 (-4.8A)
 0.29A 2uz2A-2zscA:
15.8		 2uz2A-2zscA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		4 / 7 ASN A  21
SER A  25
TYR A  41
TRP A  85
 BTN  A 400 (-3.6A)
BTN  A 400 (-2.6A)
BTN  A 400 (-4.4A)
BTN  A 400 ( 4.7A)
 0.22A 2uz2A-3ew2A:
14.7		 2uz2A-3ew2A:
28.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4bbo BLR5658 PROTEIN
(Bradyrhizobium
japonicum) 		4 / 7 ASN A   9
SER A  13
TYR A  31
TRP A  75
 BTN  A1001 (-3.3A)
BTN  A1001 (-2.6A)
BTN  A1001 (-4.9A)
BTN  A1001 (-4.9A)
 0.23A 2uz2A-4bboA:
14.6		 2uz2A-4bboA:
36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4bj8 ZEBAVIDIN
(Danio
rerio) 		7 / 7 ASN A  14
LEU A  16
SER A  18
TYR A  33
THR A  35
VAL A  37
TRP A  78
 BTN  A1123 (-3.7A)
BTN  A1123 ( 4.8A)
BTN  A1123 (-2.8A)
BTN  A1123 (-4.5A)
BTN  A1123 (-3.8A)
None
BTN  A1123 (-4.9A)
 0.35A 2uz2A-4bj8A:
18.5		 2uz2A-4bj8A:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4jnj STREPTAVIDIN/RHIZAVI
DIN HYBRID
(Streptomyces
avidinii) 		4 / 7 ASN A  23
SER A  27
TYR A  43
TRP A  92
 BTN  A 201 (-3.4A)
BTN  A 201 (-2.6A)
BTN  A 201 (-4.6A)
BTN  A 201 ( 4.8A)
 0.14A 2uz2A-4jnjA:
14.8		 2uz2A-4jnjA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 VAL A  99
TRP A  85
TRP A 102
 None
BTN  A 400 ( 4.7A)
BTN  A 400 (-3.3A)
 1.03A 2xdcA-3ew2A:
undetectable
2xdcB-3ew2A:
undetectable		 2xdcA-3ew2A:
13.64
2xdcB-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 VAL A  99
TRP A 102
TRP A  85
 None
BTN  A 400 (-3.3A)
BTN  A 400 ( 4.7A)
 0.96A 2xdcA-3ew2A:
undetectable
2xdcB-3ew2A:
undetectable		 2xdcA-3ew2A:
13.64
2xdcB-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 TRP A  85
VAL A  99
TRP A 102
 BTN  A 400 ( 4.7A)
None
BTN  A 400 (-3.3A)
 0.95A 2xdcA-3ew2A:
undetectable
2xdcB-3ew2A:
undetectable		 2xdcA-3ew2A:
13.64
2xdcB-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 TRP A 102
VAL A  99
TRP A  85
 BTN  A 400 (-3.3A)
None
BTN  A 400 ( 4.7A)
 1.04A 2xdcA-3ew2A:
undetectable
2xdcB-3ew2A:
undetectable		 2xdcA-3ew2A:
13.64
2xdcB-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 VAL A  99
TRP A  85
TRP A 102
 None
BTN  A 400 ( 4.7A)
BTN  A 400 (-3.3A)
 1.16A 2xdcC-3ew2A:
undetectable
2xdcD-3ew2A:
undetectable		 2xdcC-3ew2A:
13.64
2xdcD-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 VAL A  99
TRP A 102
TRP A  85
 None
BTN  A 400 (-3.3A)
BTN  A 400 ( 4.7A)
 0.88A 2xdcC-3ew2A:
undetectable
2xdcD-3ew2A:
undetectable		 2xdcC-3ew2A:
13.64
2xdcD-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 TRP A  85
VAL A  99
TRP A 102
 BTN  A 400 ( 4.7A)
None
BTN  A 400 (-3.3A)
 1.20A 2xdcC-3ew2A:
undetectable
2xdcD-3ew2A:
undetectable		 2xdcC-3ew2A:
13.64
2xdcD-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 TRP A  85
VAL A  99
TRP A 102
 BTN  A 400 ( 4.7A)
None
BTN  A 400 (-3.3A)
 1.17A 2xdcE-3ew2A:
undetectable
2xdcF-3ew2A:
undetectable		 2xdcE-3ew2A:
13.64
2xdcF-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 VAL A  99
TRP A  85
TRP A 102
 None
BTN  A 400 ( 4.7A)
BTN  A 400 (-3.3A)
 1.05A 2y5mA-3ew2A:
undetectable
2y5mB-3ew2A:
undetectable		 2y5mA-3ew2A:
13.64
2y5mB-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 VAL A  99
TRP A 102
TRP A  85
 None
BTN  A 400 (-3.3A)
BTN  A 400 ( 4.7A)
 0.96A 2y5mA-3ew2A:
undetectable
2y5mB-3ew2A:
undetectable		 2y5mA-3ew2A:
13.64
2y5mB-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 TRP A  85
VAL A  99
TRP A 102
 BTN  A 400 ( 4.7A)
None
BTN  A 400 (-3.3A)
 1.18A 2y5mE-3ew2A:
undetectable
2y5mF-3ew2A:
undetectable		 2y5mE-3ew2A:
13.64
2y5mF-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 VAL A  99
TRP A  85
TRP A 102
 None
BTN  A 400 ( 4.7A)
BTN  A 400 (-3.3A)
 1.05A 2y6nA-3ew2A:
undetectable
2y6nB-3ew2A:
undetectable		 2y6nA-3ew2A:
13.64
2y6nB-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 VAL A  99
TRP A 102
TRP A  85
 None
BTN  A 400 (-3.3A)
BTN  A 400 ( 4.7A)
 0.97A 2y6nA-3ew2A:
undetectable
2y6nB-3ew2A:
undetectable		 2y6nA-3ew2A:
13.64
2y6nB-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 TRP A  85
VAL A  99
TRP A 102
 BTN  A 400 ( 4.7A)
None
BTN  A 400 (-3.3A)
 0.98A 2y6nA-3ew2A:
undetectable
2y6nB-3ew2A:
undetectable		 2y6nA-3ew2A:
13.64
2y6nB-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 TRP A 102
VAL A  99
TRP A  85
 BTN  A 400 (-3.3A)
None
BTN  A 400 ( 4.7A)
 1.03A 2y6nA-3ew2A:
undetectable
2y6nB-3ew2A:
undetectable		 2y6nA-3ew2A:
13.64
2y6nB-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 TRP A  85
VAL A  99
TRP A 102
 BTN  A 400 ( 4.7A)
None
BTN  A 400 (-3.3A)
 1.17A 2y6nC-3ew2A:
undetectable
2y6nD-3ew2A:
undetectable		 2y6nC-3ew2A:
13.64
2y6nD-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 TRP A  85
VAL A  99
TRP A 102
 BTN  A 400 ( 4.7A)
None
BTN  A 400 (-3.3A)
 1.18A 2y6nE-3ew2A:
undetectable
2y6nF-3ew2A:
undetectable		 2y6nE-3ew2A:
13.64
2y6nF-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A 107
ILE A  96
GLY A 109
SER A 141
LEU A 142
 None
None
BTN  A1301 (-3.4A)
None
None
 0.98A 3ai9X-2ej9A:
undetectable		 3ai9X-2ej9A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		6 / 12 LEU A 107
GLY A 124
ILE A 140
ASN A 128
VAL A 127
SER A 141
 None
BTN  A1301 (-3.6A)
None
None
None
None
 1.49A 3nk7A-2ej9A:
undetectable		 3nk7A-2ej9A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_C_CLMC221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2c1q BIOTIN BINDING
PROTEIN A
(Gallus
gallus) 		5 / 11 PHE A  80
PHE A 121
SER A  16
TYR A  33
VAL A 116
 BTN  A1126 ( 4.8A)
None
BTN  A1126 (-2.6A)
BTN  A1126 (-4.5A)
None
 1.42A 3u9fA-2c1qA:
0.0
3u9fC-2c1qA:
0.0		 3u9fA-2c1qA:
21.31
3u9fC-2c1qA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_C_CLMC221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2c4i AVIDIN
(Gallus
gallus) 		5 / 11 PHE A  24
PHE A  65
SER A  95
TYR A 112
VAL A  60
 None
None
BTN  A1274 (-2.7A)
BTN  A1274 (-4.5A)
None
 1.45A 3u9fA-2c4iA:
0.0
3u9fC-2c4iA:
0.0		 3u9fA-2c4iA:
20.55
3u9fC-2c4iA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2c1q BIOTIN BINDING
PROTEIN A
(Gallus
gallus) 		5 / 12 PHE A  80
PHE A 121
SER A  16
TYR A  33
VAL A 116
 BTN  A1126 ( 4.8A)
None
BTN  A1126 (-2.6A)
BTN  A1126 (-4.5A)
None
 1.37A 3u9fP-2c1qA:
undetectable
3u9fS-2c1qA:
undetectable		 3u9fP-2c1qA:
21.31
3u9fS-2c1qA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 VAL A  99
TRP A  85
TRP A 102
 None
BTN  A 400 ( 4.7A)
BTN  A 400 (-3.3A)
 1.12A 3zq8A-3ew2A:
undetectable
3zq8B-3ew2A:
undetectable		 3zq8A-3ew2A:
13.64
3zq8B-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 3ew2 RHIZAVIDIN
(Rhizobium
etli) 		3 / 3 VAL A  99
TRP A 102
TRP A  85
 None
BTN  A 400 (-3.3A)
BTN  A 400 ( 4.7A)
 0.81A 3zq8A-3ew2A:
undetectable
3zq8B-3ew2A:
undetectable		 3zq8A-3ew2A:
13.64
3zq8B-3ew2A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 2c4i AVIDIN
(Gallus
gallus) 		4 / 8 ASN A 121
ASN A  14
THR A  21
TRP A  15
 None
None
None
BTN  A1274 (-3.6A)
 1.26A 4d1yA-2c4iA:
undetectable
4d1yB-2c4iA:
undetectable		 4d1yA-2c4iA:
19.34
4d1yB-2c4iA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 2c4i AVIDIN
(Gallus
gallus) 		4 / 8 ASN A 242
ASN A 269
THR A 142
TRP A 270
 None
None
None
BTN  A1275 (-3.6A)
 1.34A 4d1yA-2c4iA:
undetectable
4d1yB-2c4iA:
undetectable		 4d1yA-2c4iA:
19.34
4d1yB-2c4iA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2jgs CIRCULAR PERMUTANT
OF AVIDIN
(Gallus
gallus) 		4 / 8 SER A  59
LYS A   4
SER A  33
THR A  35
 None
None
BTN  A1001 (-2.5A)
BTN  A1001 (-3.5A)
 0.95A 4ikjA-2jgsA:
undetectable
4ikjB-2jgsA:
undetectable		 4ikjA-2jgsA:
21.74
4ikjB-2jgsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4dve BIOTIN TRANSPORTER
BIOY
(Lactococcus
lactis) 		5 / 12 LEU A  97
LEU A  69
ILE A  20
ILE A  21
LEU A  75
 None
None
None
BNG  A 202 ( 4.2A)
BTN  A 201 ( 3.8A)
 1.30A 4j26B-4dveA:
undetectable		 4j26B-4dveA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE
(Aquifex
aeolicus) 		5 / 7 LEU A  52
THR A  14
ALA A  28
LEU A 158
LEU A 155
 None
BTN  A2001 (-4.0A)
None
None
None
 1.12A 4ubsA-3efsA:
undetectable		 4ubsA-3efsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE
(Aquifex
aeolicus) 		4 / 8 GLU A  10
ASP A  32
ARG A 150
TRP A  45
 None
None
SO4  A2003 (-3.7A)
BTN  A2001 ( 3.7A)
 1.21A 4uhxA-3efsA:
undetectable		 4uhxA-3efsA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE
(Aquifex
aeolicus) 		4 / 8 GLU A  10
ASP A  32
ARG A 150
TRP A  45
 None
None
SO4  A2003 (-3.7A)
BTN  A2001 ( 3.7A)
 1.21A 4uhxA-3efsA:
undetectable		 4uhxA-3efsA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4bbo BLR5658 PROTEIN
(Bradyrhizobium
japonicum) 		5 / 12 TRP A  75
PHE A 109
ILE A  60
VAL A  64
VAL A  47
 BTN  A1001 (-4.9A)
None
None
None
None
 1.28A 4yfbC-4bboA:
undetectable		 4yfbC-4bboA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4bbo BLR5658 PROTEIN
(Bradyrhizobium
japonicum) 		5 / 12 TRP A  75
PHE A 109
ILE A  60
VAL A  64
VAL A  47
 BTN  A1001 (-4.9A)
None
None
None
None
 1.28A 4yfbF-4bboA:
undetectable		 4yfbF-4bboA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4bbo BLR5658 PROTEIN
(Bradyrhizobium
japonicum) 		5 / 12 TRP A  75
PHE A 109
ILE A  60
VAL A  64
VAL A  47
 BTN  A1001 (-4.9A)
None
None
None
None
 1.28A 4yfbI-4bboA:
undetectable		 4yfbI-4bboA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4bbo BLR5658 PROTEIN
(Bradyrhizobium
japonicum) 		5 / 12 TRP A  75
PHE A 109
ILE A  60
VAL A  64
VAL A  47
 BTN  A1001 (-4.9A)
None
None
None
None
 1.28A 4yfbL-4bboA:
undetectable		 4yfbL-4bboA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c4i AVIDIN
(Gallus
gallus) 		5 / 12 GLY A 140
TYR A 233
ILE A 220
GLY A 251
THR A  12
 None
BTN  A1275 (-4.6A)
None
None
None
 1.12A 4zdyA-2c4iA:
undetectable		 4zdyA-2c4iA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		4 / 8 SER A  11
GLY A  37
ILE A 110
GLY A  39
 BTN  A1301 (-2.6A)
BTN  A1301 (-3.4A)
None
BTN  A1301 (-3.3A)
 0.85A 5alcL-2ej9A:
undetectable		 5alcL-2ej9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c4i AVIDIN
(Gallus
gallus) 		6 / 12 GLY A 140
TYR A 233
PHE A 229
ILE A 220
GLY A 265
THR A   8
 None
BTN  A1275 (-4.6A)
None
None
None
None
 1.47A 5eskA-2c4iA:
undetectable		 5eskA-2c4iA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c4i AVIDIN
(Gallus
gallus) 		5 / 12 GLY A 140
TYR A 233
ILE A 220
GLY A 251
THR A  12
 None
BTN  A1275 (-4.6A)
None
None
None
 1.14A 5eslA-2c4iA:
undetectable		 5eslA-2c4iA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 4bj8 ZEBAVIDIN
(Danio
rerio) 		4 / 5 ARG A 113
SER A 100
SER A  74
SER A  76
 None
BTN  A1123 ( 4.8A)
BTN  A1123 (-2.5A)
BTN  A1123 (-3.3A)
 1.27A 5hswA-4bj8A:
undetectable		 5hswA-4bj8A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4bj8 ZEBAVIDIN
(Danio
rerio) 		4 / 8 THR A  40
SER A 100
SER A 111
ASP A 103
 None
BTN  A1123 ( 4.8A)
None
None
 1.02A 5l5fY-4bj8A:
undetectable
5l5fZ-4bj8A:
undetectable		 5l5fY-4bj8A:
24.41
5l5fZ-4bj8A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_A_STRA201_1
(AVIDIN)		 1wbi AVIDIN-RELATED
PROTEIN 2
(Gallus
gallus) 		6 / 10 TYR A  33
TRP A  68
PHE A  70
PHE A  77
TRP A  95
ASN A 116
 BTN  A1001 (-4.6A)
BTN  A1001 (-3.5A)
BTN  A1001 (-4.5A)
BTN  A1001 ( 4.9A)
BTN  A1001 (-3.2A)
BTN  A1001 (-3.4A)
 0.37A 5lurA-1wbiA:
18.7		 5lurA-1wbiA:
63.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_A_STRA201_1
(AVIDIN)		 2c1q BIOTIN BINDING
PROTEIN A
(Gallus
gallus) 		7 / 10 TYR A  33
TRP A  71
PHE A  73
THR A  78
PHE A  80
TRP A  98
ASN A 119
 BTN  A1126 (-4.5A)
BTN  A1126 (-3.6A)
BTN  A1126 ( 4.9A)
BTN  A1126 (-3.4A)
BTN  A1126 ( 4.8A)
BTN  A1126 (-3.3A)
BTN  A1126 (-3.2A)
 0.40A 5lurA-2c1qA:
18.2		 5lurA-2c1qA:
53.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_A_STRA201_1
(AVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		7 / 10 TYR A 112
TRP A  15
PHE A  17
THR A  22
PHE A  24
TRP A  42
ASN A  63
 BTN  A1274 (-4.5A)
BTN  A1274 (-3.6A)
BTN  A1274 (-4.6A)
BTN  A1274 (-3.3A)
None
BTN  A1274 (-3.3A)
BTN  A1274 (-3.2A)
 0.36A 5lurA-2c4iA:
0.0		 5lurA-2c4iA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_A_STRA201_1
(AVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		6 / 10 TYR A 233
TRP A 270
THR A 143
PHE A 145
TRP A 163
ASN A 184
 BTN  A1275 (-4.6A)
BTN  A1275 (-3.6A)
BTN  A1275 (-3.3A)
None
BTN  A1275 (-3.3A)
BTN  A1275 (-3.2A)
 0.38A 5lurA-2c4iA:
0.0		 5lurA-2c4iA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_A_STRA201_1
(AVIDIN)		 2jgs CIRCULAR PERMUTANT
OF AVIDIN
(Gallus
gallus) 		6 / 10 TYR A 125
TRP A  28
PHE A  30
THR A  35
PHE A  37
TRP A  55
 BTN  A1001 (-4.5A)
BTN  A1001 (-3.6A)
BTN  A1001 ( 4.8A)
BTN  A1001 (-3.5A)
None
BTN  A1001 (-3.3A)
 0.20A 5lurA-2jgsA:
8.7		 5lurA-2jgsA:
50.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_B_STRB201_1
(AVIDIN)		 1wbi AVIDIN-RELATED
PROTEIN 2
(Gallus
gallus) 		6 / 11 TYR A  33
TRP A  68
PHE A  70
PHE A  77
TRP A  95
ASN A 116
 BTN  A1001 (-4.6A)
BTN  A1001 (-3.5A)
BTN  A1001 (-4.5A)
BTN  A1001 ( 4.9A)
BTN  A1001 (-3.2A)
BTN  A1001 (-3.4A)
 0.35A 5lurB-1wbiA:
18.7		 5lurB-1wbiA:
63.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_B_STRB201_1
(AVIDIN)		 2c1q BIOTIN BINDING
PROTEIN A
(Gallus
gallus) 		7 / 11 TYR A  33
TRP A  71
PHE A  73
THR A  78
PHE A  80
TRP A  98
ASN A 119
 BTN  A1126 (-4.5A)
BTN  A1126 (-3.6A)
BTN  A1126 ( 4.9A)
BTN  A1126 (-3.4A)
BTN  A1126 ( 4.8A)
BTN  A1126 (-3.3A)
BTN  A1126 (-3.2A)
 0.37A 5lurB-2c1qA:
17.9		 5lurB-2c1qA:
53.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_B_STRB201_1
(AVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		7 / 11 TYR A 112
TRP A  15
PHE A  17
THR A  22
PHE A  24
TRP A  42
ASN A  63
 BTN  A1274 (-4.5A)
BTN  A1274 (-3.6A)
BTN  A1274 (-4.6A)
BTN  A1274 (-3.3A)
None
BTN  A1274 (-3.3A)
BTN  A1274 (-3.2A)
 0.32A 5lurB-2c4iA:
4.4		 5lurB-2c4iA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_B_STRB201_1
(AVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		6 / 11 TYR A 233
TRP A 270
THR A 143
PHE A 145
TRP A 163
ASN A 184
 BTN  A1275 (-4.6A)
BTN  A1275 (-3.6A)
BTN  A1275 (-3.3A)
None
BTN  A1275 (-3.3A)
BTN  A1275 (-3.2A)
 0.31A 5lurB-2c4iA:
4.4		 5lurB-2c4iA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_B_STRB201_1
(AVIDIN)		 2jgs CIRCULAR PERMUTANT
OF AVIDIN
(Gallus
gallus) 		6 / 11 TYR A 125
TRP A  28
PHE A  30
THR A  35
PHE A  37
TRP A  55
 BTN  A1001 (-4.5A)
BTN  A1001 (-3.6A)
BTN  A1001 ( 4.8A)
BTN  A1001 (-3.5A)
None
BTN  A1001 (-3.3A)
 0.22A 5lurB-2jgsA:
7.7		 5lurB-2jgsA:
50.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 2c4i AVIDIN
(Gallus
gallus) 		5 / 9 SER A 126
SER A  18
ILE A 256
THR A 117
THR A 114
 None
BTN  A1274 (-3.3A)
None
BTN  A1274 (-4.0A)
BTN  A1274 (-3.7A)
 1.48A 5muoA-2c4iA:
0.0
5muoB-2c4iA:
0.3
5muoC-2c4iA:
0.0
5muoD-2c4iA:
0.0
5muoE-2c4iA:
0.0		 5muoA-2c4iA:
12.92
5muoB-2c4iA:
12.92
5muoC-2c4iA:
12.92
5muoD-2c4iA:
12.92
5muoE-2c4iA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 107
ILE A  96
GLY A 109
LEU A 142
LEU A 150
 None
None
BTN  A1301 (-3.4A)
None
None
 1.15A 5nfjB-2ej9A:
undetectable		 5nfjB-2ej9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 107
ILE A  96
GLY A 109
LEU A 142
LEU A 150
 None
None
BTN  A1301 (-3.4A)
None
None
 1.12A 5nfjC-2ej9A:
undetectable		 5nfjC-2ej9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE
(Aquifex
aeolicus) 		5 / 10 ILE A 161
VAL A 107
LEU A 108
PHE A  56
GLU A 110
 None
None
BTN  A2001 ( 4.1A)
None
None
 1.30A 5tixB-3efsA:
undetectable		 5tixB-3efsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE
(Aquifex
aeolicus) 		5 / 10 PRO A  70
VAL A 107
LEU A 108
PHE A  56
GLU A 110
 None
None
BTN  A2001 ( 4.1A)
None
None
 1.34A 5tixB-3efsA:
undetectable		 5tixB-3efsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2ej9 PUTATIVE BIOTIN
LIGASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 107
ILE A  96
GLY A 109
SER A 141
LEU A 142
 None
None
BTN  A1301 (-3.4A)
None
None
 0.94A 5twjC-2ej9A:
undetectable		 5twjC-2ej9A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 5vyw PYRUVATE CARBOXYLASE
(Lactococcus
lactis) 		4 / 5 ASN A 474
GLN A1051
ASP A1050
SER A1052
 None
BTN  A1202 ( 4.7A)
None
None
 1.28A 5w4zA-5vywA:
8.5		 5w4zA-5vywA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 10 ALA A 352
ASP A 349
PHE A 379
VAL A 423
THR A 351
 None
None
BTN  A5602 (-4.8A)
None
None
 1.37A 6aogA-1xnyA:
undetectable		 6aogA-1xnyA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 10 ALA A 352
ASP A 349
PHE A 379
VAL A 423
THR A 351
 None
None
BTN  A5602 (-4.8A)
None
None
 1.35A 6aogB-1xnyA:
undetectable		 6aogB-1xnyA:
8.67