SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BTI'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 12 ALA A1319
GLY A1479
GLY A1347
GLY A1348
LEU A1484
 None
None
BTI  A1901 (-3.1A)
BTI  A1901 (-4.3A)
None
 0.95A 1eizA-3va7A:
3.5		 1eizA-3va7A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 12 ALA A1319
GLY A1479
GLY A1347
GLY A1348
LEU A1484
 None
None
BTI  A1901 (-3.1A)
BTI  A1901 (-4.3A)
None
 0.94A 1ej0A-3va7A:
3.3		 1ej0A-3va7A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 11 ARG A1610
SER A1609
GLY A1635
ASN A1330
PHE A1349
 URE  A1902 ( 4.9A)
BTI  A1901 ( 3.5A)
URE  A1902 (-3.0A)
BTI  A1901 (-3.8A)
BTI  A1901 (-4.6A)
 1.42A 1ho5A-3va7A:
undetectable		 1ho5A-3va7A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 10 ARG A1610
SER A1609
GLY A1635
ASN A1330
PHE A1349
 URE  A1902 ( 4.9A)
BTI  A1901 ( 3.5A)
URE  A1902 (-3.0A)
BTI  A1901 (-3.8A)
BTI  A1901 (-4.6A)
 1.44A 1ho5B-3va7A:
undetectable		 1ho5B-3va7A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 12 PHE A1374
VAL A1363
LEU A1360
GLY A1294
TYR A1275
 None
None
None
BTI  A1901 ( 3.9A)
None
 1.17A 2cbrA-3va7A:
undetectable		 2cbrA-3va7A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		4 / 7 PHE A1349
GLY A1635
TRP A1549
ARG A1544
 BTI  A1901 (-4.6A)
URE  A1902 (-3.0A)
None
None
 1.26A 3aruA-3va7A:
undetectable		 3aruA-3va7A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		4 / 4 PHE A1349
TYR A1606
ILE A1298
LEU A1297
 BTI  A1901 (-4.6A)
None
None
None
 1.45A 3sudA-3va7A:
undetectable		 3sudA-3va7A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		4 / 5 PHE A1349
TYR A1606
ILE A1298
LEU A1297
 BTI  A1901 (-4.6A)
None
None
None
 1.36A 3sueC-3va7A:
undetectable		 3sueC-3va7A:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		5 / 12 ASP A1584
ASP A1321
GLY A1636
SER A1609
ARG A1296
 URE  A1902 (-4.0A)
None
URE  A1902 (-3.7A)
BTI  A1901 ( 3.5A)
GOL  A1907 (-3.4A)
 1.04A 4djfB-3va7A:
undetectable		 4djfB-3va7A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 3va7 KLLA0E08119P
(Kluyveromyces
lactis) 		4 / 7 THR A1611
TYR A1612
PRO A1634
THR A1613
 None
None
BTI  A1901 (-4.6A)
None
 1.26A 5b6iA-3va7A:
undetectable		 5b6iA-3va7A:
16.35