SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BT5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		7 / 7 ARG A  51
TRP A  53
GLU A  54
ALA A 111
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-4.0A)
BT5  A1301 (-3.8A)
None
BT5  A1301 ( 3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.57A 2ejfA-2djzA:
39.1		 2ejfA-2djzA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A  48
TRP A  53
ASN A 131
ALA A 111
 None
BT5  A1301 (-3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 ( 3.8A)
 1.11A 2ejfB-2djzA:
40.1		 2ejfB-2djzA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 6 ARG A  51
TRP A  53
ASN A 131
ALA A 111
 BT5  A1301 (-4.0A)
BT5  A1301 (-3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 ( 3.8A)
 1.25A 2ejfB-2djzA:
40.1		 2ejfB-2djzA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		6 / 6 ARG A  51
TRP A  53
GLU A  54
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-4.0A)
BT5  A1301 (-3.8A)
None
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.44A 2ejfB-2djzA:
40.1		 2ejfB-2djzA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		4 / 7 ARG A  48
TRP A  53
ASN A 131
ALA A 111
 None
BT5  A1301 (-3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 ( 3.8A)
 1.18A 2ejgA-2djzA:
38.4		 2ejgA-2djzA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		6 / 7 ARG A  51
TRP A  53
GLU A  54
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-4.0A)
BT5  A1301 (-3.8A)
None
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.50A 2ejgA-2djzA:
38.4		 2ejgA-2djzA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		5 / 7 TRP A  53
GLU A  54
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-3.8A)
None
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.28A 2ejgB-2djzA:
39.2		 2ejgB-2djzA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		6 / 7 TRP A  53
GLU A  54
ALA A 111
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-3.8A)
None
BT5  A1301 ( 3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.10A 2zgwA-2djzA:
43.5		 2zgwA-2djzA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		6 / 6 TRP A  53
GLU A  54
ALA A 111
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-3.8A)
None
BT5  A1301 ( 3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.17A 2zgwB-2djzA:
41.2		 2zgwB-2djzA:
99.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		5 / 9 ALA A 113
ASP A 104
GLY A  85
ILE A  95
ILE A 112
 None
BT5  A1301 (-3.3A)
None
None
None
 0.97A 3s43A-2djzA:
undetectable		 3s43A-2djzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE
(Pyrococcus
horikoshii) 		6 / 12 GLY A 129
ALA A 113
ASP A 104
GLY A  85
ILE A  95
ILE A 112
 BT5  A1301 (-3.7A)
None
BT5  A1301 (-3.3A)
None
None
None
 1.23A 5e5jB-2djzA:
undetectable		 5e5jB-2djzA:
22.03