SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BRF'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_B_X2NB1479_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	1uuo	DIHYDROOROTATE DEHYDROGENASE (Rattus rattus)	5 / 12	MET A 43 ALA A 55 ALA A 59 THR A 63 LEU A 111	BRF A1397 (-4.1A) BRF A1397 (-3.2A) BRF A1397 (-3.5A) BRF A1397 ( 4.7A) None	1.07A	2x2nB-1uuoA: undetectable	2x2nB-1uuoA: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_C_X2NC1479_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	1uuo	DIHYDROOROTATE DEHYDROGENASE (Rattus rattus)	5 / 12	MET A 43 ALA A 55 ALA A 59 THR A 63 LEU A 111	BRF A1397 (-4.1A) BRF A1397 (-3.2A) BRF A1397 (-3.5A) BRF A1397 ( 4.7A) None	1.06A	2x2nC-1uuoA: undetectable	2x2nC-1uuoA: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_D_X2ND1479_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	1uuo	DIHYDROOROTATE DEHYDROGENASE (Rattus rattus)	5 / 12	MET A 43 ALA A 55 ALA A 59 THR A 63 LEU A 111	BRF A1397 (-4.1A) BRF A1397 (-3.2A) BRF A1397 (-3.5A) BRF A1397 ( 4.7A) None	1.05A	2x2nD-1uuoA: 0.0	2x2nD-1uuoA: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VW7_A_VPXA2001_1 (PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME)	1uuo	DIHYDROOROTATE DEHYDROGENASE (Rattus rattus)	5 / 12	LEU A 67 PHE A 37 LEU A 42 TYR A 38 ALA A 55	None None BRF A1397 (-4.6A) None BRF A1397 (-3.2A)	1.09A	3vw7A-1uuoA: undetectable	3vw7A-1uuoA: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JX1_B_CAMB502_0 (CAMPHOR 5-MONOOXYGENASE)	1uuo	DIHYDROOROTATE DEHYDROGENASE (Rattus rattus)	6 / 10	PHE A 98 THR A 63 LEU A 68 VAL A 116 ASP A 99 ILE A 94	None BRF A1397 ( 4.7A) None None None None	1.32A	4jx1B-1uuoA: undetectable	4jx1B-1uuoA: 22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5K9D_A_CE9A402_0 (DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL)	1uuo	DIHYDROOROTATE DEHYDROGENASE (Rattus rattus)	10 / 12	MET A 43 ALA A 55 HIS A 56 LEU A 58 ALA A 59 THR A 63 PHE A 98 TYR A 356 LEU A 359 PRO A 364	BRF A1397 (-4.1A) BRF A1397 (-3.2A) BRF A1397 (-4.0A) None BRF A1397 (-3.5A) BRF A1397 ( 4.7A) None FMN A1398 ( 4.2A) None BRF A1397 (-4.6A)	0.64A	5k9dA-1uuoA: 60.9	5k9dA-1uuoA: 87.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AY4_A_TPFA506_1 (CYP51, STEROL 14ALPHA-DEMETHYLASE)	1uuo	DIHYDROOROTATE DEHYDROGENASE (Rattus rattus)	5 / 10	MET A 43 ALA A 55 ALA A 59 THR A 63 LEU A 111	BRF A1397 (-4.1A) BRF A1397 (-3.2A) BRF A1397 (-3.5A) BRF A1397 ( 4.7A) None	1.08A	6ay4A-1uuoA: undetectable	6ay4A-1uuoA: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AYC_A_1YNA502_1 (PROTEIN CYP51)	1uuo	DIHYDROOROTATE DEHYDROGENASE (Rattus rattus)	5 / 12	MET A 43 ALA A 55 ALA A 59 THR A 63 LEU A 111	BRF A1397 (-4.1A) BRF A1397 (-3.2A) BRF A1397 (-3.5A) BRF A1397 ( 4.7A) None	1.07A	6aycA-1uuoA: undetectable	6aycA-1uuoA: 16.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2X2N_B_X2NB1479_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","1uuo","DIHYDROOROTATE DEHYDROGENASE","Rattus rattus",5,"MET A  43;ALA A  55;ALA A  59;THR A  63;LEU A 111","BRF A1397 (-4.1A);BRF A1397 (-3.2A);BRF A1397 (-3.5A);BRF A1397 ( 4.7A);None","1.07A","2x2nB-1uuoA:undetectable",null],["2X2N_C_X2NC1479_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","1uuo","DIHYDROOROTATE DEHYDROGENASE","Rattus rattus",5,"MET A  43;ALA A  55;ALA A  59;THR A  63;LEU A 111","BRF A1397 (-4.1A);BRF A1397 (-3.2A);BRF A1397 (-3.5A);BRF A1397 ( 4.7A);None","1.06A","2x2nC-1uuoA:undetectable","2x2nB-1uuoA:21.26"],["2X2N_D_X2ND1479_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","1uuo","DIHYDROOROTATE DEHYDROGENASE","Rattus rattus",5,"MET A  43;ALA A  55;ALA A  59;THR A  63;LEU A 111","BRF A1397 (-4.1A);BRF A1397 (-3.2A);BRF A1397 (-3.5A);BRF A1397 ( 4.7A);None","1.05A","2x2nD-1uuoA:0.0","2x2nC-1uuoA:21.26"],["3VW7_A_VPXA2001_1","PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME","1uuo","DIHYDROOROTATE DEHYDROGENASE","Rattus rattus",5,"LEU A  67;PHE A  37;LEU A  42;TYR A  38;ALA A  55","None;None;BRF A1397 (-4.6A);None;BRF A1397 (-3.2A)","1.09A","3vw7A-1uuoA:undetectable","2x2nD-1uuoA:21.26"],["4JX1_B_CAMB502_0","CAMPHOR 5-MONOOXYGENASE","1uuo","DIHYDROOROTATE DEHYDROGENASE","Rattus rattus",6,"PHE A  98;THR A  63;LEU A  68;VAL A 116;ASP A  99;ILE A  94","None;BRF A1397 ( 4.7A);None;None;None;None","1.32A","4jx1B-1uuoA:undetectable","3vw7A-1uuoA:21.83"],["5K9D_A_CE9A402_0","DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL","1uuo","DIHYDROOROTATE DEHYDROGENASE","Rattus rattus",10,"MET A  43;ALA A  55;HIS A  56;LEU A  58;ALA A  59;THR A  63;PHE A  98;TYR A 356;LEU A 359;PRO A 364","BRF A1397 (-4.1A);BRF A1397 (-3.2A);BRF A1397 (-4.0A);None;BRF A1397 (-3.5A);BRF A1397 ( 4.7A);None;FMN A1398 ( 4.2A);None;BRF A1397 (-4.6A)","0.64A","5k9dA-1uuoA:60.9","4jx1B-1uuoA:22.88"],["6AY4_A_TPFA506_1","CYP51, STEROL 14ALPHA-DEMETHYLASE","1uuo","DIHYDROOROTATE DEHYDROGENASE","Rattus rattus",5,"MET A  43;ALA A  55;ALA A  59;THR A  63;LEU A 111","BRF A1397 (-4.1A);BRF A1397 (-3.2A);BRF A1397 (-3.5A);BRF A1397 ( 4.7A);None","1.08A","6ay4A-1uuoA:undetectable","5k9dA-1uuoA:87.63"],["6AYC_A_1YNA502_1","PROTEIN CYP51","1uuo","DIHYDROOROTATE DEHYDROGENASE","Rattus rattus",5,"MET A  43;ALA A  55;ALA A  59;THR A  63;LEU A 111","BRF A1397 (-4.1A);BRF A1397 (-3.2A);BRF A1397 (-3.5A);BRF A1397 ( 4.7A);None","1.07A","6aycA-1uuoA:undetectable","6ay4A-1uuoA:20.87"]]