SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BR8'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 7 ARG A 188
GLY A 334
SER A 227
SER A  79
 BR8  A 401 (-4.1A)
BR8  A 401 (-3.6A)
BR8  A 401 (-4.8A)
BR8  A 401 (-2.7A)
 1.08A 2c8aB-4nq3A:
undetectable		 2c8aB-4nq3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 7 ARG A 188
GLY A 334
SER A 227
SER A  79
 BR8  A 401 (-4.1A)
BR8  A 401 (-3.6A)
BR8  A 401 (-4.8A)
BR8  A 401 (-2.7A)
 1.08A 2c8aD-4nq3A:
undetectable		 2c8aD-4nq3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		4 / 8 ARG A 194
HIS A 348
GLN A 349
THR A 183
 BR8  A1365 (-3.8A)
None
None
None
 1.30A 2vxaF-4bvtA:
0.8
2vxaG-4bvtA:
0.8
2vxaI-4bvtA:
0.8		 2vxaF-4bvtA:
11.17
2vxaG-4bvtA:
11.17
2vxaI-4bvtA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 8 ARG A 188
HIS A 338
GLN A 339
THR A 177
 BR8  A 401 (-4.1A)
None
None
BR8  A 408 (-3.3A)
 1.35A 2vxaF-4nq3A:
2.5
2vxaG-4nq3A:
2.4
2vxaI-4nq3A:
2.5		 2vxaF-4nq3A:
12.76
2vxaG-4nq3A:
12.76
2vxaI-4nq3A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		4 / 5 SER A 308
GLU A 337
SER A 226
GLN A 154
 None
None
BR8  A 401 (-3.4A)
None
 1.48A 5fhrB-4nq3A:
undetectable		 5fhrB-4nq3A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 SER A 220
HIS A 338
GLU A 287
GLY A 336
GLY A 334
 None
None
MG  A 409 (-3.3A)
MG  A 409 (-3.9A)
BR8  A 401 (-3.6A)
 1.09A 5l6eA-4nq3A:
undetectable		 5l6eA-4nq3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4nq3 CYANURIC ACID
AMIDOHYDROLASE
(Azorhizobium
caulinodans) 		5 / 12 ASP A  49
GLY A  39
GLY A  80
PHE A  90
VAL A  77
 None
None
BR8  A 401 (-3.2A)
None
None
 1.31A 6clxA-4nq3A:
undetectable		 6clxA-4nq3A:
25.99