SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BPY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		5 / 12 HIS B 194
ALA B 145
GLY B 144
HIS B 209
ASP B 243
 BPY  B 401 (-4.3A)
None
None
BPY  B 401 (-3.7A)
BPY  B 401 (-3.9A)
 1.37A 1a4lD-1kwcB:
undetectable		 1a4lD-1kwcB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		4 / 5 ILE B  16
PRO B 224
SER B 188
GLY B  15
 NAD  B 301 (-3.7A)
None
BPY  B 303 ( 4.9A)
NAD  B 301 (-3.2A)
 1.12A 3tkdB-5xtgB:
undetectable		 3tkdB-5xtgB:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5xtg 2,3-DIHYDROXY-2,3-DI
HYDROPHENYLPROPIONAT
E DEHYDROGENASE
(Pseudomonas
sp.
MC1) 		4 / 5 ILE B  16
PRO B 224
SER B 188
GLY B  15
 NAD  B 301 (-3.7A)
None
BPY  B 303 ( 4.9A)
NAD  B 301 (-3.2A)
 1.11A 3tkdA-5xtgB:
undetectable		 3tkdA-5xtgB:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		3 / 3 SER B 247
TYR B 249
ASP B 243
 None
None
BPY  B 401 (-3.9A)
 0.88A 4rp8C-1kwcB:
0.0		 4rp8C-1kwcB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 6 ALA B 145
SER B 247
ASP B 243
PRO B 265
 None
None
BPY  B 401 (-3.9A)
None
 1.14A 5c6pA-1kwcB:
undetectable		 5c6pA-1kwcB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		4 / 7 ILE B 143
GLY B 142
LEU B 198
PHE B 186
 None
None
None
BPY  B 401 (-4.4A)
 0.60A 5hieB-1kwcB:
undetectable		 5hieB-1kwcB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE
(Pseudomonas
sp.
KKS102) 		3 / 3 ASP B 243
ASN B 190
GLN B 141
 BPY  B 401 (-3.9A)
None
None
 0.79A 5k7uA-1kwcB:
0.7		 5k7uA-1kwcB:
18.67