SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BPH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 11 LEU L 246
ALA L 245
ILE L 237
HIS L 198
LEU L 195
 None
BPH  L 606 ( 4.9A)
None
None
None
 1.26A 1g50A-1eysL:
undetectable		 1g50A-1eysL:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 6 ALA L 101
TYR L 156
ILE L  99
ILE L  97
 BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
None
None
 0.96A 2dcfA-1eysL:
0.0		 2dcfA-1eysL:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 6 ALA L 101
TYR L 156
TYR L 136
ILE L  97
 BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
BCL  L 604 ( 4.4A)
None
 1.28A 2dcfA-1eysL:
0.0		 2dcfA-1eysL:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 7 ALA L 101
TYR L 156
ILE L  99
ILE L  97
 BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
None
None
 0.95A 2zm7A-1eysL:
undetectable		 2zm7A-1eysL:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		4 / 7 ALA L  93
TYR L 148
ILE L  91
ILE L  89
 BPH  L 271 (-4.0A)
BPH  L 271 ( 4.1A)
None
None
 1.09A 2zm7A-1pssL:
undetectable		 2zm7A-1pssL:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 8 ALA L 101
TYR L 156
ILE L  99
ILE L  97
 BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
None
None
 0.95A 2zm8A-1eysL:
undetectable		 2zm8A-1eysL:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 8 ALA L 101
TYR L 156
ILE L  99
ILE L  97
 BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
None
None
 0.96A 2zmaA-1eysL:
0.0		 2zmaA-1eysL:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5yq7 PRECURSOR FOR M
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER
(Roseiflexus
castenholzii) 		4 / 7 ILE M 505
LEU M 489
PHE M 486
LEU M 479
 BPH  M 703 (-4.1A)
None
None
BCL  M 702 (-4.6A)
 0.87A 3adxA-5yq7M:
undetectable		 3adxA-5yq7M:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		3 / 4 SER M 152
GLY L 191
GLU M 263
 BPH  M   5 ( 4.1A)
None
None
 0.54A 3raeA-1pssM:
undetectable
3raeC-1pssM:
undetectable		 3raeA-1pssM:
18.85
3raeC-1pssM:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 11 PHE L  34
GLY L  38
SER L 107
ALA L 102
ALA L 101
 None
None
None
None
BPH  L 606 ( 3.9A)
 1.19A 3sufC-1eysL:
undetectable		 3sufC-1eysL:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		4 / 7 ASN L 183
ALA M 213
VAL L 241
ILE L 117
 None
BPH  L 271 ( 3.7A)
BPH  L 271 (-4.3A)
BPH  L 271 (-4.9A)
 0.77A 4eyrA-1pssL:
undetectable		 4eyrA-1pssL:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 12 LEU L 246
ALA L 245
ILE L 237
HIS L 198
LEU L 195
 None
BPH  L 606 ( 4.9A)
None
None
None
 1.23A 4j24D-1eysL:
undetectable		 4j24D-1eysL:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		3 / 4 SER M 152
GLY L 191
GLU M 263
 BPH  M   5 ( 4.1A)
None
None
 0.55A 4juoA-1pssM:
0.0
4juoC-1pssM:
undetectable		 4juoA-1pssM:
18.85
4juoC-1pssM:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		4 / 8 ALA M 273
PHE M 150
THR M 133
PHE L 215
 BPH  M   5 (-4.2A)
BPH  M   5 (-3.7A)
BPH  M   5 ( 4.2A)
None
 1.00A 4ltwA-1pssM:
undetectable		 4ltwA-1pssM:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1pss PHOTOSYNTHETIC
REACTION CENTER
(Rhodobacter
sphaeroides) 		4 / 8 LEU L 189
ILE M 270
VAL M 276
THR M 277
 U10  L 272 ( 4.1A)
None
None
BPH  M   5 (-3.3A)
 0.96A 4ma7A-1pssL:
undetectable		 4ma7A-1pssL:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 11 LEU L 246
ALA L 245
ILE L 237
HIS L 198
LEU L 195
 None
BPH  L 606 ( 4.9A)
None
None
None
 1.20A 4pxmB-1eysL:
0.3		 4pxmB-1eysL:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 8 ALA L 104
ALA L 101
ALA L 132
TYR L 136
LEU L 137
 BPH  L 606 ( 4.1A)
BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
BCL  L 604 ( 4.4A)
None
 1.46A 4v1fA-1eysL:
2.7
4v1fB-1eysL:
2.8		 4v1fA-1eysL:
16.07
4v1fB-1eysL:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 5yq7 PRECURSOR FOR L
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER
(Roseiflexus
castenholzii) 		4 / 5 ILE L 105
LEU L  82
GLY L  83
PHE L  86
 None
None
BPH  L1003 ( 4.5A)
None
 0.57A 5kmdC-5yq7L:
3.4
5kmdD-5yq7L:
2.4		 5kmdC-5yq7L:
16.12
5kmdD-5yq7L:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5yq7 CYTOCHROME SUBUNIT
OF PHOTOSYNTHETIC
REACTION CENTER
PRECURSOR FOR L
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER
PRECURSOR FOR M
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER
(Roseiflexus
castenholzii) 		4 / 6 THR M 509
TYR M 511
TYR L 204
PHE C 227
 BPH  M 703 ( 4.7A)
None
HEM  C 503 (-4.4A)
None
 1.32A 5lrbA-5yq7M:
undetectable		 5lrbA-5yq7M:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5yq7 CYTOCHROME SUBUNIT
OF PHOTOSYNTHETIC
REACTION CENTER
PRECURSOR FOR L
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER
PRECURSOR FOR M
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER
(Roseiflexus
castenholzii) 		4 / 6 THR M 509
TYR M 511
TYR L 208
PHE C 227
 BPH  M 703 ( 4.7A)
None
None
None
 1.26A 5lrbA-5yq7M:
undetectable		 5lrbA-5yq7M:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 10 LEU L 246
ALA L 245
ILE L 237
HIS L 198
LEU L 195
 None
BPH  L 606 ( 4.9A)
None
None
None
 1.21A 6cbzB-1eysL:
undetectable		 6cbzB-1eysL:
14.78