SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BMP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A   7
ILE A 176
GLY A 178
ALA A  10
LEU A  11
 None
BMP  A 301 ( 4.6A)
BMP  A 301 (-3.4A)
BMP  A 301 ( 3.9A)
None
 1.03A 1cqeA-4df1A:
undetectable		 1cqeA-4df1A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  47
LEU A  24
ILE A 209
GLY A 211
ALA A  27
 None
None
BMP  A 301 ( 4.4A)
BMP  A 301 (-3.5A)
BMP  A 301 ( 3.7A)
 1.03A 1cqeA-4lujA:
undetectable		 1cqeA-4lujA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A   7
ILE A 176
GLY A 178
ALA A  10
LEU A  11
 None
BMP  A 301 ( 4.6A)
BMP  A 301 (-3.4A)
BMP  A 301 ( 3.9A)
None
 1.03A 1cqeB-4df1A:
undetectable		 1cqeB-4df1A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  47
LEU A  24
ILE A 209
GLY A 211
ALA A  27
 None
None
BMP  A 301 ( 4.4A)
BMP  A 301 (-3.5A)
BMP  A 301 ( 3.7A)
 1.03A 1cqeB-4lujA:
undetectable		 1cqeB-4lujA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		5 / 12 SER A 189
GLY A 167
TYR A 173
GLY A 187
SER A 163
 None
None
None
BMP  A 301 (-3.3A)
None
 1.07A 1fduC-4dbeA:
undetectable		 1fduC-4dbeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A 213
TYR A 215
ILE A 214
ASP A  29
 None
None
None
BMP  A 301 (-2.9A)
 1.25A 1upfA-4lujA:
undetectable		 1upfA-4lujA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A   7
ILE A 176
GLY A 178
ALA A  10
LEU A  11
 None
BMP  A 301 ( 4.6A)
BMP  A 301 (-3.4A)
BMP  A 301 ( 3.9A)
None
 1.05A 2aylB-4df1A:
undetectable		 2aylB-4df1A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  47
LEU A  24
ILE A 209
GLY A 211
ALA A  27
 None
None
BMP  A 301 ( 4.4A)
BMP  A 301 (-3.5A)
BMP  A 301 ( 3.7A)
 1.07A 2aylB-4lujA:
undetectable		 2aylB-4lujA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		5 / 12 THR A 131
ILE A 162
TYR A 128
PRO A 186
ILE A 183
 None
BMP  A 301 ( 4.9A)
None
BMP  A 301 (-4.3A)
None
 1.18A 2y7kC-4muzA:
undetectable		 2y7kC-4muzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		5 / 12 THR A 131
ILE A 162
LEU A 171
PRO A 186
ILE A 183
 None
BMP  A 301 ( 4.9A)
None
BMP  A 301 (-4.3A)
None
 1.14A 2y7kD-4muzA:
undetectable		 2y7kD-4muzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4muz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Archaeoglobus
fulgidus) 		5 / 12 THR A 131
ILE A 162
TYR A 128
PRO A 186
ILE A 183
 None
BMP  A 301 ( 4.9A)
None
BMP  A 301 (-4.3A)
None
 1.08A 2y7kD-4muzA:
undetectable		 2y7kD-4muzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  47
LEU A  24
ILE A 209
GLY A 211
ALA A  27
 None
None
BMP  A 301 ( 4.4A)
BMP  A 301 (-3.5A)
BMP  A 301 ( 3.7A)
 1.00A 3kk6A-4lujA:
undetectable		 3kk6A-4lujA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A   7
ILE A 176
GLY A 178
ALA A  10
LEU A  11
 None
BMP  A 301 ( 4.6A)
BMP  A 301 (-3.4A)
BMP  A 301 ( 3.9A)
None
 1.18A 3n8xA-4df1A:
undetectable		 3n8xA-4df1A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		5 / 12 LEU A   7
ILE A 176
GLY A 178
ALA A  10
LEU A  11
 None
BMP  A 301 ( 4.6A)
BMP  A 301 (-3.4A)
BMP  A 301 ( 3.9A)
None
 1.06A 3n8zB-4df1A:
undetectable		 3n8zB-4df1A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  47
LEU A  24
ILE A 209
GLY A 211
ALA A  27
 None
None
BMP  A 301 ( 4.4A)
BMP  A 301 (-3.5A)
BMP  A 301 ( 3.7A)
 1.05A 3n8zB-4lujA:
undetectable		 3n8zB-4lujA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 209
LYS A  69
LYS A 126
GLY A 102
 BMP  A 301 ( 4.4A)
None
None
None
 1.16A 3sj0X-4lujA:
undetectable		 3sj0X-4lujA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Pyrobaculum
neutrophilum) 		4 / 4 ILE A 153
SER A 154
ASP A  59
ASP A  37
 None
None
BMP  A 301 (-3.8A)
None
 1.45A 4krhB-4df1A:
undetectable		 4krhB-4df1A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4dbe OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Sulfolobus
solfataricus) 		3 / 3 GLY A 142
GLY A 143
GLN A 169
 None
None
BMP  A 301 (-3.3A)
 0.45A 5imsA-4dbeA:
undetectable		 5imsA-4dbeA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  96
ALA A  78
LYS A  51
 None
None
BMP  A 301 (-2.8A)
 0.57A 6fgcA-4lujA:
undetectable		 6fgcA-4lujA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  96
ALA A  78
LYS A  51
 None
None
BMP  A 301 (-2.8A)
 0.54A 6fgdA-4lujA:
undetectable		 6fgdA-4lujA:
19.71