SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BMF'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)
5c4q BROMODOMAIN
(Leishmania
donovani)
4 / 5 VAL A  48
TYR A  45
VAL A  36
ASP A  53
None
UNX  A 203 ( 4.4A)
BMF  A 201 (-4.6A)
None
1.31A 2x45C-5c4qA:
undetectable
2x45C-5c4qA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)
5c4q BROMODOMAIN
(Leishmania
donovani)
3 / 3 VAL A  47
ASN A  87
TRP A  93
None
BMF  A 201 (-2.8A)
BMF  A 201 (-3.5A)
1.03A 2y00B-5c4qA:
undetectable
2y00B-5c4qA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum)
4 / 8 VAL A 332
LEU A 338
ASN A 413
ILE A 422
BMF  A 501 (-4.2A)
BMF  A 501 ( 4.9A)
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
0.77A 3u5kA-5u9nA:
14.3
3u5kA-5u9nA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum)
4 / 7 VAL A 332
LEU A 338
ASN A 413
ILE A 422
BMF  A 501 (-4.2A)
BMF  A 501 ( 4.9A)
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
0.78A 3u5kB-5u9nA:
14.2
3u5kB-5u9nA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum)
4 / 8 VAL A 332
LEU A 338
ASN A 413
ILE A 422
BMF  A 501 (-4.2A)
BMF  A 501 ( 4.9A)
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
0.80A 3u5kC-5u9nA:
14.3
3u5kC-5u9nA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum)
4 / 5 VAL A 332
LEU A 338
ASN A 413
ILE A 422
BMF  A 501 (-4.2A)
BMF  A 501 ( 4.9A)
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
0.84A 4a9jA-5u9nA:
15.4
4a9jA-5u9nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum)
4 / 5 VAL A 332
LEU A 338
ASN A 413
ILE A 422
BMF  A 501 (-4.2A)
BMF  A 501 ( 4.9A)
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
0.81A 4a9jB-5u9nA:
15.7
4a9jB-5u9nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum)
4 / 5 VAL A 332
LEU A 338
ASN A 413
ILE A 422
BMF  A 501 (-4.2A)
BMF  A 501 ( 4.9A)
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
0.77A 4a9jC-5u9nA:
15.2
4a9jC-5u9nA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)
5c4q BROMODOMAIN
(Leishmania
donovani)
4 / 7 TYR A  44
MET A  79
ALA A  83
ASN A  87
BMF  A 201 ( 4.9A)
None
BMF  A 201 ( 4.1A)
BMF  A 201 (-2.8A)
0.32A 4y03A-5c4qA:
13.3
4y03A-5c4qA:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)
5c4q BROMODOMAIN
(Leishmania
donovani)
4 / 6 VAL A  36
VAL A  41
TYR A  44
ASN A  87
BMF  A 201 (-4.6A)
BMF  A 201 (-4.2A)
BMF  A 201 ( 4.9A)
BMF  A 201 (-2.8A)
0.92A 5pbeA-5c4qA:
15.2
5pbeA-5c4qA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum)
4 / 6 VAL A 332
TYR A 346
ASN A 413
ILE A 422
BMF  A 501 (-4.2A)
None
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
0.65A 5pbeA-5u9nA:
15.3
5pbeA-5u9nA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum)
5 / 8 VAL A 332
LEU A 338
CYH A 409
ASN A 413
ILE A 422
BMF  A 501 (-4.2A)
BMF  A 501 ( 4.9A)
BMF  A 501 ( 3.8A)
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
0.77A 5y1yA-5u9nA:
14.2
5y1yA-5u9nA:
24.18