SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BK5'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		6 / 9 LEU A  57
VAL A  65
LYS A  80
LEU A 114
LEU A 126
LEU A 198
 BK5  A 701 ( 4.2A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.5A)
BK5  A 701 ( 4.5A)
BK5  A 701 (-3.3A)
BK5  A 701 ( 4.9A)
 0.52A 1xkkA-3sxfA:
24.2		 1xkkA-3sxfA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		7 / 12 VAL A  65
ALA A  78
LYS A  80
LEU A 126
LEU A 181
ASP A 195
LEU A 198
 BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 (-4.0A)
BK5  A 701 ( 4.9A)
 0.89A 3bbtD-3sxfA:
23.9		 3bbtD-3sxfA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		6 / 11 LEU A  57
GLY A  58
GLY A  60
VAL A  65
ALA A  78
LEU A 181
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 ( 4.6A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
None
 0.65A 4ckiA-3sxfA:
22.0		 4ckiA-3sxfA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		8 / 12 LEU A  57
GLY A  58
VAL A  65
ALA A  78
LYS A  80
LEU A 126
LEU A 181
ASP A 195
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 (-4.0A)
 0.85A 4i22A-3sxfA:
23.1		 4i22A-3sxfA:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		12 / 12 GLY A  58
VAL A  65
ALA A  78
LYS A  80
MET A 112
LEU A 114
LEU A 126
GLY A 134
GLU A 135
LEU A 181
ILE A 194
LEU A 198
 BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
BK5  A 701 ( 4.5A)
BK5  A 701 (-3.3A)
None
None
None
BK5  A 701 ( 3.5A)
BK5  A 701 ( 4.9A)
 0.32A 4ifgA-3sxfA:
54.1		 4ifgA-3sxfA:
99.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		7 / 12 GLY A  58
VAL A  65
LYS A  80
LEU A 114
LEU A 126
GLU A 178
ILE A 194
 BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.5A)
BK5  A 701 ( 4.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 ( 3.5A)
 1.23A 4ifgA-3sxfA:
54.1		 4ifgA-3sxfA:
99.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		8 / 11 LEU A  57
GLY A  58
VAL A  65
ALA A  78
LYS A  80
ASN A 179
LEU A 181
ASP A 195
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
None
None
BK5  A 701 (-4.0A)
 0.93A 4o0sA-3sxfA:
26.7		 4o0sA-3sxfA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 VAL A  65
ALA A  78
LYS A  80
LEU A 181
 BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
None
 0.42A 4o0uA-3sxfA:
9.2		 4o0uA-3sxfA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		5 / 6 LEU A  57
GLY A  58
VAL A  65
ALA A  78
LEU A 181
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
None
 0.41A 4o0wA-3sxfA:
26.6		 4o0wA-3sxfA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		4 / 6 LEU A  57
VAL A  65
ILE A 111
ILE A 193
 BK5  A 701 ( 4.2A)
BK5  A 701 (-4.2A)
None
None
 0.32A 4tyjA-3sxfA:
21.4		 4tyjA-3sxfA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		7 / 11 LEU A  57
GLY A  58
VAL A  65
ALA A  78
GLU A 135
GLU A 178
LEU A 181
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
None
None
None
 0.50A 5lvnA-3sxfA:
24.6		 5lvnA-3sxfA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		7 / 12 GLY A  58
VAL A  65
ALA A  78
LYS A  80
GLY A 134
GLU A 135
ILE A 194
 BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
None
None
BK5  A 701 ( 3.5A)
 0.82A 5mafA-3sxfA:
26.2		 5mafA-3sxfA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		8 / 12 LEU A  57
GLY A  58
VAL A  65
ALA A  78
LYS A  80
LEU A 126
LEU A 181
ASP A 195
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 (-4.0A)
 0.81A 5yu9A-3sxfA:
23.3		 5yu9A-3sxfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		7 / 12 GLY A  58
VAL A  65
ALA A  78
LYS A  80
LEU A 126
LEU A 181
ASP A 195
 BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 (-4.0A)
 0.70A 5yu9B-3sxfA:
23.6		 5yu9B-3sxfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		5 / 12 VAL A  65
ALA A  78
LYS A  80
LEU A 126
ASP A 195
 BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
BK5  A 701 (-4.0A)
 0.39A 5yu9C-3sxfA:
23.6		 5yu9C-3sxfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1
(Toxoplasma
gondii) 		6 / 12 VAL A  65
ALA A  78
LYS A  80
LEU A 181
ASP A 195
LEU A 198
 BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
None
BK5  A 701 (-4.0A)
BK5  A 701 ( 4.9A)
 0.63A 5yu9D-3sxfA:
23.8		 5yu9D-3sxfA:
11.36