SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BIG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_A_ADNA1260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 10 VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-2.9A)
 0.62A 1jdvA-3dp9A:
23.8
1jdvD-3dp9A:
23.7		 1jdvA-3dp9A:
24.90
1jdvD-3dp9A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_B_ADNB2260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 10 VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-2.9A)
 0.61A 1jdvB-3dp9A:
23.5
1jdvC-3dp9A:
23.3		 1jdvB-3dp9A:
24.90
1jdvC-3dp9A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_D_ADND3260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 10 VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-2.9A)
 0.60A 1jdvA-3dp9A:
23.8
1jdvD-3dp9A:
23.7		 1jdvA-3dp9A:
24.90
1jdvD-3dp9A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		7 / 12 GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 0.59A 1jdvE-3dp9A:
23.6
1jdvF-3dp9A:
23.3		 1jdvE-3dp9A:
24.90
1jdvF-3dp9A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 11 GLY A  78
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.7A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.50A 1odiA-3dp9A:
17.8		 1odiA-3dp9A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 11 GLY A  78
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.7A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.53A 1odiB-3dp9A:
25.6		 1odiB-3dp9A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 11 GLY A  78
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.7A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.44A 1odiC-3dp9A:
25.2		 1odiC-3dp9A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 11 GLY A  78
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.7A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.53A 1odiD-3dp9A:
25.5		 1odiD-3dp9A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 11 GLY A  78
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.7A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.53A 1odiE-3dp9A:
25.5		 1odiE-3dp9A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 11 GLY A  78
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.7A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.53A 1odiF-3dp9A:
25.2		 1odiF-3dp9A:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		7 / 9 SER A  76
GLY A  78
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 0.57A 1pk7A-3dp9A:
23.7		 1pk7A-3dp9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 8 GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.61A 1pk7B-3dp9A:
23.8		 1pk7B-3dp9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 10 GLY A  79
VAL A 172
GLU A 173
SER A 197
ASP A 198
 None
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 1.39A 1pk7C-3dp9A:
24.7		 1pk7C-3dp9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		8 / 10 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 0.49A 1pk7C-3dp9A:
24.7		 1pk7C-3dp9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		8 / 10 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 0.45A 1pk9A-3dp9A:
23.7		 1pk9A-3dp9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		7 / 9 SER A  76
GLY A  78
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 0.47A 1pk9B-3dp9A:
23.9		 1pk9B-3dp9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		8 / 11 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 0.40A 1pk9C-3dp9A:
24.7		 1pk9C-3dp9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		7 / 10 SER A  76
GLY A  78
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 0.54A 1pw7A-3dp9A:
23.7		 1pw7A-3dp9A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 9 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.46A 1pw7B-3dp9A:
24.2		 1pw7B-3dp9A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		7 / 9 SER A  76
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 0.51A 1pw7C-3dp9A:
24.6		 1pw7C-3dp9A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 11 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.44A 1vhwA-3dp9A:
24.4
1vhwD-3dp9A:
24.3		 1vhwA-3dp9A:
24.42
1vhwD-3dp9A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 9 SER A  76
GLY A  78
VAL A 172
MET A 174
GLU A 175
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.39A 1vhwB-3dp9A:
24.5
1vhwF-3dp9A:
24.3		 1vhwB-3dp9A:
24.42
1vhwF-3dp9A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 11 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.43A 1vhwC-3dp9A:
24.4
1vhwE-3dp9A:
24.5		 1vhwC-3dp9A:
24.42
1vhwE-3dp9A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 11 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.44A 1vhwA-3dp9A:
24.4
1vhwD-3dp9A:
24.3		 1vhwA-3dp9A:
24.42
1vhwD-3dp9A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 11 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.45A 1vhwC-3dp9A:
24.4
1vhwE-3dp9A:
24.5		 1vhwC-3dp9A:
24.42
1vhwE-3dp9A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 10 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.45A 1vhwB-3dp9A:
24.5
1vhwF-3dp9A:
24.3		 1vhwB-3dp9A:
24.42
1vhwF-3dp9A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 10 GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.50A 1z35A-3dp9A:
24.0		 1z35A-3dp9A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 9 GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.51A 1z37A-3dp9A:
24.1		 1z37A-3dp9A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 11 GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-2.9A)
 0.54A 2ac7A-3dp9A:
23.7
2ac7B-3dp9A:
23.6		 2ac7A-3dp9A:
24.80
2ac7B-3dp9A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 11 GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-2.9A)
 0.54A 2ac7A-3dp9A:
23.7
2ac7B-3dp9A:
23.6		 2ac7A-3dp9A:
24.80
2ac7B-3dp9A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_A_ADNA251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 9 SER A  76
VAL A 172
GLU A 173
MET A 174
GLU A 175
 BIG  A 301 (-3.3A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.63A 3u40A-3dp9A:
24.1
3u40F-3dp9A:
23.7		 3u40A-3dp9A:
25.98
3u40F-3dp9A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_B_ADNB251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 10 SER A  76
VAL A 172
GLU A 173
MET A 174
GLU A 175
 BIG  A 301 (-3.3A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.58A 3u40B-3dp9A:
24.1
3u40C-3dp9A:
24.1		 3u40B-3dp9A:
25.98
3u40C-3dp9A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		7 / 12 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-2.9A)
 0.53A 3u40B-3dp9A:
24.1
3u40C-3dp9A:
24.1		 3u40B-3dp9A:
25.98
3u40C-3dp9A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		7 / 11 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-2.9A)
 0.53A 3u40D-3dp9A:
24.3
3u40E-3dp9A:
24.0		 3u40D-3dp9A:
25.98
3u40E-3dp9A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		7 / 12 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-2.9A)
 0.49A 3u40D-3dp9A:
24.3
3u40E-3dp9A:
24.0		 3u40D-3dp9A:
25.98
3u40E-3dp9A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_F_ADNF251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 10 SER A  76
VAL A 172
GLU A 173
MET A 174
GLU A 175
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-2.9A)
 0.81A 3u40A-3dp9A:
24.1
3u40F-3dp9A:
23.7		 3u40A-3dp9A:
25.98
3u40F-3dp9A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		7 / 11 GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 0.51A 3uawA-3dp9A:
24.7		 3uawA-3dp9A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 10 GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
 BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.54A 3uayA-3dp9A:
24.4		 3uayA-3dp9A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 9 ALA A 176
ILE A 146
ARG A 194
VAL A 191
ASN A  73
 None
None
BIG  A 301 ( 4.8A)
None
None
 1.36A 4a3uA-3dp9A:
undetectable		 4a3uA-3dp9A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 10 GLY A   7
GLU A 175
GLY A  75
SER A  76
PHE A 208
 None
BIG  A 301 (-2.8A)
None
BIG  A 301 (-3.3A)
BIG  A 301 (-4.3A)
 0.85A 4bwlC-3dp9A:
undetectable		 4bwlC-3dp9A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		7 / 11 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.58A 4d9hA-3dp9A:
24.3		 4d9hA-3dp9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 11 SER A  76
GLY A  78
VAL A 172
SER A 197
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 0.78A 4d9hA-3dp9A:
24.3		 4d9hA-3dp9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 9 SER A  76
GLY A  78
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.60A 4da6A-3dp9A:
23.8		 4da6A-3dp9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 9 SER A  76
GLY A  78
VAL A 172
MET A 174
GLU A 175
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.54A 4da6A-3dp9A:
23.8		 4da6A-3dp9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 10 GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.58A 4da7A-3dp9A:
24.3		 4da7A-3dp9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		7 / 11 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.62A 4danA-3dp9A:
23.8		 4danA-3dp9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 11 SER A  76
GLY A  78
VAL A 172
GLU A 173
SER A 197
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 0.86A 4danA-3dp9A:
23.8		 4danA-3dp9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		8 / 12 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
BIG  A 301 (-2.9A)
 0.81A 4danA-3dp9A:
23.8
4danB-3dp9A:
24.0		 4danA-3dp9A:
22.88
4danB-3dp9A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		4 / 8 SER A 197
SER A  76
ILE A  50
GLU A 173
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.3A)
BIG  A 301 (-3.8A)
None
 1.18A 4ms4A-3dp9A:
2.9		 4ms4A-3dp9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 9 SER A  76
GLY A  78
VAL A 172
MET A 174
GLU A 175
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.31A 5i3cA-3dp9A:
24.2		 5i3cA-3dp9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		6 / 10 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
 0.39A 5i3cB-3dp9A:
24.7		 5i3cB-3dp9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		7 / 11 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
GLU A 175
SER A 197
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.8A)
BIG  A 301 (-3.3A)
 0.44A 5i3cC-3dp9A:
24.2		 5i3cC-3dp9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 12 ALA A  55
MET A   9
ILE A  50
GLY A  75
ILE A 179
 None
BIG  A 301 ( 4.1A)
BIG  A 301 (-3.8A)
None
None
 1.10A 5m24A-3dp9A:
undetectable		 5m24A-3dp9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 9 SER A  76
GLY A  78
VAL A 172
GLU A 173
MET A 174
 BIG  A 301 (-3.3A)
BIG  A 301 (-3.7A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
 0.48A 5zncA-3dp9A:
23.7		 5zncA-3dp9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNC_A_QI9A301_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		5 / 9 SER A  76
VAL A 172
GLU A 173
MET A 174
ASP A 198
 BIG  A 301 (-3.3A)
BIG  A 301 (-4.9A)
None
BIG  A 301 (-3.6A)
BIG  A 301 (-2.9A)
 1.03A 5zncA-3dp9A:
23.7		 5zncA-3dp9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 3dp9 MTA/SAH NUCLEOSIDASE
(Vibrio
cholerae) 		3 / 3 SER A 220
SER A 219
ALA A   8
 None
None
BIG  A 301 ( 3.8A)
 0.73A 6dwnC-3dp9A:
undetectable		 6dwnC-3dp9A:
18.36