SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BI1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		8 / 12 VAL A 259
ALA A 272
VAL A 307
VAL A 326
ASN A 374
LEU A 376
THR A 386
ASP A 387
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-4.4A)
BI1  A1000 (-3.9A)
None
BI1  A1000 (-4.8A)
BI1  A1000 (-3.2A)
BI1  A1000 (-4.5A)
 0.78A 1fmoE-1zrzA:
35.9		 1fmoE-1zrzA:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 6 ILE A 251
VAL A 259
VAL A 296
ILE A 365
ASP A 387
 BI1  A1000 (-3.9A)
BI1  A1000 (-4.2A)
None
None
BI1  A1000 (-4.5A)
 0.94A 1uwhB-1zrzA:
22.6		 1uwhB-1zrzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		8 / 12 VAL A 259
LYS A 274
VAL A 307
VAL A 326
ASP A 330
ASN A 374
LEU A 376
ASP A 387
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
BI1  A1000 (-4.4A)
BI1  A1000 (-3.9A)
BI1  A1000 (-4.3A)
None
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 0.94A 2eufB-1zrzA:
25.8		 2eufB-1zrzA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		3 / 3 VAL A 259
VAL A 322
ASP A 378
 BI1  A1000 (-4.2A)
None
None
 0.69A 2fumD-1zrzA:
24.8		 2fumD-1zrzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 7 TYR A 256
GLU A 293
TYR A 367
GLY A 389
 None
BI1  A1000 ( 4.9A)
None
None
 1.24A 2ha4B-1zrzA:
undetectable		 2ha4B-1zrzA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		6 / 11 VAL A 259
ALA A 272
LYS A 274
ASP A 330
LEU A 376
ASP A 387
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
BI1  A1000 (-4.3A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 0.64A 4iaaA-1zrzA:
28.4		 4iaaA-1zrzA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 7 VAL A 259
ALA A 272
ASP A 330
LEU A 376
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-4.3A)
BI1  A1000 (-4.8A)
 0.63A 4l9iA-1zrzA:
12.9		 4l9iA-1zrzA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 12 VAL A 262
ALA A 272
TYR A 271
GLY A 241
SER A 311
 None
BI1  A1000 (-3.4A)
None
None
None
 1.17A 4mmdB-1zrzA:
undetectable		 4mmdB-1zrzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 9 VAL A 262
ALA A 272
TYR A 271
GLY A 241
SER A 311
 None
BI1  A1000 (-3.4A)
None
None
None
 1.25A 4mmfA-1zrzA:
undetectable		 4mmfA-1zrzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 9 VAL A 262
ALA A 272
TYR A 271
GLY A 241
SER A 311
 None
BI1  A1000 (-3.4A)
None
None
None
 1.21A 4mmfB-1zrzA:
undetectable		 4mmfB-1zrzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMN_A_DB8A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		7 / 12 ILE A 251
ALA A 272
LYS A 274
GLU A 293
TYR A 325
LEU A 376
ASP A 387
 BI1  A1000 (-3.9A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
BI1  A1000 ( 4.9A)
BI1  A1000 (-4.2A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 0.85A 4qmnA-1zrzA:
28.6		 4qmnA-1zrzA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		6 / 12 ILE A 251
GLY A 252
VAL A 259
ALA A 272
TYR A 325
LEU A 376
 BI1  A1000 (-3.9A)
BI1  A1000 (-3.6A)
BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-4.2A)
BI1  A1000 (-4.8A)
 0.67A 4qmzA-1zrzA:
21.5		 4qmzA-1zrzA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		6 / 10 ILE A 251
ALA A 272
LYS A 274
PHE A 321
VAL A 326
LEU A 376
 BI1  A1000 (-3.9A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
None
BI1  A1000 (-3.9A)
BI1  A1000 (-4.8A)
 0.59A 4rz7A-1zrzA:
12.4		 4rz7A-1zrzA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		5 / 8 ILE A 251
VAL A 259
VAL A 296
ILE A 365
ASP A 387
 BI1  A1000 (-3.9A)
BI1  A1000 (-4.2A)
None
None
BI1  A1000 (-4.5A)
 0.95A 5hi2A-1zrzA:
22.4		 5hi2A-1zrzA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 7 GLY A 252
GLY A 254
SER A 255
LYS A 274
 BI1  A1000 (-3.6A)
None
None
BI1  A1000 (-3.5A)
 0.75A 5izfA-1zrzA:
30.6		 5izfA-1zrzA:
34.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 7 GLY A 252
GLY A 254
VAL A 259
LYS A 274
 BI1  A1000 (-3.6A)
None
BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
 0.37A 5izjA-1zrzA:
36.8		 5izjA-1zrzA:
34.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 7 GLY A 252
GLY A 254
VAL A 259
LYS A 274
 BI1  A1000 (-3.6A)
None
BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
 0.30A 5j5xA-1zrzA:
36.0		 5j5xA-1zrzA:
34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		7 / 12 ILE A 251
GLY A 252
VAL A 259
ALA A 272
LYS A 274
GLU A 293
TYR A 325
 BI1  A1000 (-3.9A)
BI1  A1000 (-3.6A)
BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
BI1  A1000 ( 4.9A)
BI1  A1000 (-4.2A)
 0.56A 5mafA-1zrzA:
28.8		 5mafA-1zrzA:
10.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		7 / 10 VAL A 259
ALA A 272
VAL A 307
TYR A 325
VAL A 326
LEU A 376
THR A 386
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-4.4A)
BI1  A1000 (-4.2A)
BI1  A1000 (-3.9A)
BI1  A1000 (-4.8A)
BI1  A1000 (-3.2A)
 0.81A 5n3hA-1zrzA:
36.4		 5n3hA-1zrzA:
36.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		4 / 4 VAL A 259
LYS A 274
VAL A 307
ASN A 374
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
BI1  A1000 (-4.4A)
None
 0.85A 5vc3A-1zrzA:
25.2		 5vc3A-1zrzA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		3 / 3 LYS A 274
LEU A 376
ASP A 387
 BI1  A1000 (-3.5A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 0.93A 5zv2A-1zrzA:
12.1		 5zv2A-1zrzA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens) 		7 / 12 VAL A 259
ALA A 272
LYS A 274
GLU A 293
VAL A 307
LEU A 376
ASP A 387
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
BI1  A1000 ( 4.9A)
BI1  A1000 (-4.4A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 1.06A 6hd4A-1zrzA:
20.0		 6hd4A-1zrzA:
14.04