SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BGL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		4 / 5 LEU A 104
ALA A 116
ILE A 113
SER A 173
 None
None
BGL  A 305 ( 4.8A)
BGL  A 305 ( 3.9A)
 0.96A 2othA-4tkrA:
undetectable		 2othA-4tkrA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		5 / 12 GLY B 198
GLY B 199
TRP B 200
LEU B  99
ALA B 117
 BGL  B 603 (-3.9A)
BGL  B 602 ( 3.8A)
None
None
None
 0.81A 3douA-1rc2B:
undetectable		 3douA-1rc2B:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		5 / 10 LEU A 109
ALA A 116
GLY A 169
ILE A 171
ILE A 113
 None
None
None
None
BGL  A 305 ( 4.8A)
 1.00A 3ekpC-4tkrA:
undetectable		 3ekpC-4tkrA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 1rc2 AQUAPORIN Z
(Escherichia
coli) 		4 / 7 SER B 118
GLY B 198
GLY B 199
ALA B 201
 None
BGL  B 603 (-3.9A)
BGL  B 602 ( 3.8A)
None
 0.68A 4yjiA-1rc2B:
undetectable		 4yjiA-1rc2B:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 12 ALA L 180
HIS L 181
LEU L 183
ALA L 184
PHE L 187
 None
BCL  L 602 (-4.0A)
BGL  L 701 (-3.3A)
BCL  L 602 (-3.5A)
None
 0.67A 5k9dA-1eysL:
0.0		 5k9dA-1eysL:
22.59