SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BG6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 6 TYR A 354
ILE A 287
GLU A 285
PHE A 296
 None
None
BG6  A 550 (-2.6A)
None
 1.44A 1oniA-5aq1A:
undetectable
1oniC-5aq1A:
undetectable		 1oniA-5aq1A:
13.88
1oniC-5aq1A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		3 / 3 SER A 155
ASP A 413
CYH A 217
 BG6  A1002 ( 3.4A)
BG6  A1002 (-2.6A)
None
 1.13A 2br4E-2nztA:
undetectable		 2br4E-2nztA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 ASN A 299
ILE A 173
GLN A 170
THR A 121
 None
None
BG6  A 501 (-3.0A)
None
 1.21A 2hkkA-4zfmA:
undetectable		 2hkkA-4zfmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		3 / 3 SER A 155
HIS A 129
ASP A 117
 BG6  A1002 ( 3.4A)
None
None
 0.73A 2wa2B-2nztA:
undetectable		 2wa2B-2nztA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens) 		4 / 6 ARG A 246
GLN A 395
GLU A 239
TYR A 202
 None
BG6  A 601 (-3.2A)
BG6  A 601 (-2.9A)
BG6  A 601 (-4.8A)
 1.42A 2ya7C-5ukwA:
undetectable		 2ya7C-5ukwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A  79
ASN A 169
HIS A 124
ALA A  20
 None
None
BG6  A 501 (-4.2A)
BG6  A 501 ( 4.9A)
 1.29A 3frqB-4zfmA:
undetectable		 3frqB-4zfmA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 4 ARG A 190
ASP A  84
GLY A 212
THR A 457
 None
BG6  A1002 ( 2.8A)
None
None
 1.12A 3k4vB-2nztA:
undetectable		 3k4vB-2nztA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		4 / 5 LEU G 279
THR G 277
GLU G 249
HIS G 256
 None
BG6  G1092 (-3.6A)
BG6  G1092 (-4.7A)
None
 1.19A 3n58C-2nzuG:
4.9		 3n58C-2nzuG:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		4 / 8 GLN A  81
ARG A  86
HIS A  82
ARG A  57
 BG6  A 501 (-3.8A)
BG6  A 501 (-3.0A)
BG6  A 501 (-4.2A)
BG6  A 501 (-2.9A)
 1.16A 3uy4A-2cirA:
undetectable		 3uy4A-2cirA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE
(Trypanosoma
cruzi) 		4 / 8 PHE A 283
VAL A 305
HIS A 247
TYR A 248
 None
None
BG6  A 550 (-3.8A)
BG6  A 550 (-4.4A)
 1.17A 4f5zA-5aq1A:
undetectable		 4f5zA-5aq1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		4 / 6 ASP G  99
ASP G  69
ASN G  72
ALA G  76
 None
None
BG6  G1092 (-3.7A)
None
 1.06A 4mdaA-2nzuG:
undetectable		 4mdaA-2nzuG:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 3hm8 HEXOKINASE-3
(Homo
sapiens) 		5 / 12 ILE A 683
GLY A 868
ASP A 663
GLU A 748
THR A 664
 GLC  A1001 (-4.2A)
BG6  A1002 (-3.5A)
GLC  A1001 ( 2.9A)
GLC  A1001 (-3.1A)
GLC  A1001 (-4.1A)
 1.33A 4xt8A-3hm8A:
undetectable		 4xt8A-3hm8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 12 ASN A 109
MET A 119
ILE A 114
PHE A 175
ASP A 413
 None
None
None
None
BG6  A1002 (-2.6A)
 1.47A 4zjqD-2nztA:
0.0		 4zjqD-2nztA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 12 TYR G 161
PHE G  74
LEU G  78
SER G 147
VAL G  65
 None
BG6  G1092 (-3.3A)
None
None
None
 1.43A 5h1eA-2nzuG:
0.0		 5h1eA-2nzuG:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		5 / 12 ILE A 229
ALA A 236
GLY A 448
GLY A 411
GLY A  87
 GLC  A1001 (-4.2A)
None
BG6  A1002 (-3.6A)
None
UNX  A   6 ( 3.4A)
 0.98A 5i73A-2nztA:
undetectable		 5i73A-2nztA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 TYR A  22
THR A  52
TRP A 433
LEU A 434
 None
None
BG6  A 501 (-4.1A)
None
 1.47A 5kxiA-4zfmA:
undetectable
5kxiB-4zfmA:
undetectable		 5kxiA-4zfmA:
22.49
5kxiB-4zfmA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2nzu CATABOLITE CONTROL
PROTEIN
(Bacillus
megaterium) 		5 / 12 ILE G  73
ILE G 121
LEU G  95
VAL G  65
ILE G  67
 BG6  G1092 (-4.4A)
None
None
None
None
 0.96A 5mueA-2nzuG:
1.5		 5mueA-2nzuG:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.29A 5ttfB-4zfmA:
undetectable		 5ttfB-4zfmA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.25A 5tuyA-4zfmA:
undetectable		 5tuyA-4zfmA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.26A 5tuyB-4zfmA:
undetectable		 5tuyB-4zfmA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.35A 5v9iA-4zfmA:
undetectable		 5v9iA-4zfmA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.29A 5vscA-4zfmA:
undetectable		 5vscA-4zfmA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.29A 5vscB-4zfmA:
undetectable		 5vscB-4zfmA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
TRP A  38
 None
BG6  A 501 (-3.4A)
None
None
None
 1.27A 5vsdA-4zfmA:
undetectable		 5vsdA-4zfmA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.33A 5vseA-4zfmA:
undetectable		 5vseA-4zfmA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
GLN A  44
 None
BG6  A 501 (-3.4A)
None
None
None
 1.29A 5vseB-4zfmA:
undetectable		 5vseB-4zfmA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  51
SER A 432
ASN A  53
TYR A  22
TRP A  38
 None
BG6  A 501 (-3.4A)
None
None
None
 1.26A 5vsfA-4zfmA:
undetectable		 5vsfA-4zfmA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 ASP A 126
GLN A  23
LEU A 430
SER A  19
 None
BG6  A 501 (-3.1A)
None
None
 1.22A 6ekuA-4zfmA:
undetectable		 6ekuA-4zfmA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  86
LYS A  54
TYR A  27
 BG6  A 501 (-3.0A)
None
None
 1.15A 6gnaA-2cirA:
undetectable		 6gnaA-2cirA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  86
LYS A  54
TYR A  27
 BG6  A 501 (-3.0A)
None
None
 1.15A 6gnbA-2cirA:
undetectable		 6gnbA-2cirA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2nzt HEXOKINASE-2
(Homo
sapiens) 		4 / 7 ALA A 236
GLY A 227
GLY A 231
CYH A 386
 None
None
BG6  A1002 (-3.5A)
None
 0.76A 6nm4A-2nztA:
undetectable		 6nm4A-2nztA:
11.24