SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BFD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 8 PHE A 264
ILE A 241
LEU A 230
VAL A 169
 None
None
None
BFD  A 170 ( 3.0A)
 0.90A 1fslB-3ef1A:
undetectable		 1fslB-3ef1A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 453
ILE A 233
VAL A 169
ILE A 257
PHE A 229
 None
None
BFD  A 170 ( 3.0A)
None
None
 1.13A 3b2rA-3ef1A:
undetectable		 3b2rA-3ef1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 453
ILE A 233
VAL A 169
ILE A 257
PHE A 229
 None
None
BFD  A 170 ( 3.0A)
None
None
 1.10A 3b2rB-3ef1A:
undetectable		 3b2rB-3ef1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3hzh CHEMOTAXIS RESPONSE
REGULATOR (CHEY-3)
CHEMOTAXIS OPERON
PROTEIN (CHEX)
(Borreliella
burgdorferi;
Borreliella
burgdorferi) 		5 / 10 VAL B 106
THR A  81
ILE A  80
LYS A 111
LEU A 114
 None
BFD  A  79 (-3.9A)
BFD  A  79 ( 3.9A)
None
None
 1.41A 3bexE-3hzhB:
undetectable
3bexF-3hzhB:
undetectable		 3bexE-3hzhB:
23.97
3bexF-3hzhB:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3hzh CHEMOTAXIS OPERON
PROTEIN (CHEX)
(Borreliella
burgdorferi) 		4 / 8 VAL B  47
VAL B 153
ASN B  99
GLY B  98
 None
None
BFD  A  79 ( 3.2A)
None
 0.68A 3hjoB-3hzhB:
undetectable		 3hjoB-3hzhB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 3hzh CHEMOTAXIS OPERON
PROTEIN (CHEX)
(Borreliella
burgdorferi) 		4 / 7 VAL B  47
VAL B 153
ASN B  99
GLY B  98
 None
None
BFD  A  79 ( 3.2A)
None
 0.64A 3kmoB-3hzhB:
undetectable		 3kmoB-3hzhB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 230
PHE A 229
ILE A 175
PHE A 317
 None
None
BFD  A 170 ( 4.0A)
None
 0.74A 3ko0B-3ef1A:
undetectable		 3ko0B-3ef1A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 230
PHE A 229
ILE A 175
PHE A 317
 None
None
BFD  A 170 ( 4.0A)
None
 0.70A 3ko0S-3ef1A:
undetectable		 3ko0S-3ef1A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5uj0 POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		4 / 7 ASP A 278
GLY A 212
THR A 169
LYS A 258
 MG  A 401 (-2.7A)
BFD  A 165 ( 3.7A)
BFD  A 165 ( 3.6A)
BFD  A 165 ( 2.8A)
 1.06A 3vnsA-5uj0A:
3.6		 3vnsA-5uj0A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 5uj0 POLYNUCLEOTIDE
KINASE
(Escherichia
virus
T4) 		5 / 12 VAL A 209
LEU A 170
THR A 169
VAL A 238
PRO A 239
 None
BFD  A 165 ( 3.5A)
BFD  A 165 ( 3.6A)
None
None
 1.04A 4xiwB-5uj0A:
undetectable
4xiwE-5uj0A:
undetectable		 4xiwB-5uj0A:
19.18
4xiwE-5uj0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE
(Schizosaccharomy
ces
pombe) 		4 / 5 VAL A 253
HIS A 177
LEU A 226
ASP A 172
 None
None
None
BFD  A 170 (-4.2A)
 1.41A 5vcvA-3ef1A:
undetectable		 5vcvA-3ef1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3hzh CHEMOTAXIS RESPONSE
REGULATOR (CHEY-3)
(Borreliella
burgdorferi) 		3 / 3 TYR A  66
LEU A  78
ASP A  86
 None
BFD  A  79 ( 3.7A)
None
 0.78A 5zv2B-3hzhA:
undetectable		 5zv2B-3hzhA:
20.59