SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BET'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		4 / 7 GLN A 110
GLU A 217
PHE A  98
ALA A 144
 None
None
None
BET  A 310 ( 4.0A)
 1.37A 1linA-3tmgA:
undetectable		 1linA-3tmgA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT
HYDRAZINE SYNTHASE
BETA SUBUNIT
(Candidatus
Kuenenia
stuttgartiensis;
Candidatus
Kuenenia
stuttgartiensis) 		5 / 12 ARG B 336
PRO B 279
GLY A 593
ILE A 299
LEU B 283
 BET  B 403 (-4.3A)
None
None
None
None
 1.09A 3iv6C-5c2vB:
undetectable		 3iv6C-5c2vB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		5 / 12 GLY A 145
ALA A 144
PHE A  89
VAL A 149
GLN A 152
 BET  A 310 (-3.7A)
BET  A 310 ( 4.0A)
None
None
None
 1.19A 3nvkF-3tmgA:
undetectable
3nvkJ-3tmgA:
undetectable		 3nvkF-3tmgA:
21.58
3nvkJ-3tmgA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		3 / 3 GLN A 147
THR A 146
LEU A 174
 None
BET  A 310 (-3.9A)
None
 0.75A 3ondA-3tmgA:
undetectable		 3ondA-3tmgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		3 / 3 GLN A 147
THR A 146
LEU A 174
 None
BET  A 310 (-3.9A)
None
 0.76A 3ondB-3tmgA:
undetectable		 3ondB-3tmgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		5 / 12 LEU A  45
PHE A 241
GLU A  38
VAL A  79
GLY A 260
 None
None
BET  A 310 (-4.1A)
None
None
 1.37A 5f9zB-3tmgA:
3.1		 5f9zB-3tmgA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		4 / 8 TYR A 191
MET A 170
TRP A 188
THR A 134
 None
None
BET  A1001 (-3.7A)
None
 1.48A 5l8dA-1r9lA:
7.0		 5l8dA-1r9lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		4 / 8 TYR A 191
MET A 170
TRP A 188
THR A 134
 None
None
BET  A1001 (-3.7A)
None
 1.48A 5mwuA-1r9lA:
7.0		 5mwuA-1r9lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE
(Methanohalophilu
s
portucalensis) 		4 / 5 HIS A 183
VAL A 192
PHE A 255
ARG A 167
 None
None
BET  A 303 (-4.6A)
BET  A 303 (-4.3A)
 1.40A 6hxiB-5h02A:
5.6		 6hxiB-5h02A:
18.61