SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BES'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		6 / 12 THR A 350
HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 BES  A1950 ( 4.3A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.77A 1j36A-2yd0A:
5.9		 1j36A-2yd0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.69A 1j36A-4gaaA:
3.3		 1j36A-4gaaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.82A 1j36A-4kxbA:
6.8		 1j36A-4kxbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		6 / 12 THR A 350
HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 BES  A1950 ( 4.3A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.77A 1j36B-2yd0A:
6.7		 1j36B-2yd0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.69A 1j36B-4gaaA:
3.3		 1j36B-4gaaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.83A 1j36B-4kxbA:
3.8		 1j36B-4kxbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.77A 1j37A-2yd0A:
6.4		 1j37A-2yd0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 11 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.68A 1j37A-4gaaA:
3.2		 1j37A-4gaaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 11 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.80A 1j37A-4kxbA:
3.8		 1j37A-4kxbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.78A 1j37B-2yd0A:
6.6		 1j37B-2yd0A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 11 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.69A 1j37B-4gaaA:
3.5		 1j37B-4gaaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 11 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.81A 1j37B-4kxbA:
6.8		 1j37B-4kxbA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 GLY A 266
ARG A 534
VAL A 279
LEU A 286
ALA A 287
 BES  A 702 (-4.3A)
None
None
None
None
 0.94A 1jipA-4gaaA:
undetectable		 1jipA-4gaaA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.75A 1o86A-2yd0A:
6.7		 1o86A-2yd0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.67A 1o86A-4gaaA:
3.3		 1o86A-4gaaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.78A 1o86A-4kxbA:
4.0		 1o86A-4kxbA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.91A 1v7zA-4gaaA:
undetectable		 1v7zA-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.91A 1v7zB-4gaaA:
undetectable		 1v7zB-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.92A 1v7zC-4gaaA:
undetectable		 1v7zC-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.93A 1v7zD-4gaaA:
undetectable		 1v7zD-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.93A 1v7zE-4gaaA:
undetectable		 1v7zE-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.92A 1v7zF-4gaaA:
undetectable		 1v7zF-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		5 / 11 VAL A 353
GLY A 354
LEU A 344
ARG A 343
SER A 417
 None
None
None
BES  A 501 (-2.5A)
BES  A 501 (-4.4A)
 1.24A 2bxgA-4ruhA:
undetectable		 2bxgA-4ruhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		6 / 12 ALA A 318
HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 BES  A1950 (-4.9A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.72A 2c6nA-2yd0A:
6.6		 2c6nA-2yd0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.62A 2c6nA-4gaaA:
3.3		 2c6nA-4gaaA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		6 / 12 ALA A 358
HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 BES  A1017 (-4.6A)
ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.75A 2c6nA-4kxbA:
3.9		 2c6nA-4kxbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.80A 2c6nB-2yd0A:
3.9		 2c6nB-2yd0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.72A 2c6nB-4gaaA:
3.4		 2c6nB-4gaaA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.82A 2c6nB-4kxbA:
undetectable		 2c6nB-4kxbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 7 GLY A 265
SER A 288
ARG A 560
GLU A 322
 BES  A 702 (-3.2A)
None
BES  A 702 (-4.0A)
BES  A 702 ( 4.6A)
 1.08A 2c8aD-4gaaA:
undetectable		 2c8aD-4gaaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 8 THR A 350
HIS A 353
GLU A 354
HIS A 357
 BES  A1950 ( 4.3A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
 0.23A 2jihB-2yd0A:
3.8		 2jihB-2yd0A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 GLU A 360
HIS A 393
GLU A 394
 BES  A1017 (-2.9A)
ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
 0.88A 2x45C-4kxbA:
undetectable		 2x45C-4kxbA:
10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.70A 2x8zA-2yd0A:
7.0		 2x8zA-2yd0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 11 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.60A 2x8zA-4gaaA:
5.8		 2x8zA-4gaaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 11 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.72A 2x8zA-4kxbA:
8.0		 2x8zA-4kxbA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.72A 2x91A-2yd0A:
5.4		 2x91A-2yd0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.63A 2x91A-4gaaA:
3.4		 2x91A-4gaaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.75A 2x91A-4kxbA:
5.7		 2x91A-4kxbA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.92A 3a6jA-4gaaA:
undetectable		 3a6jA-4gaaA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 7 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.90A 3a6jB-4gaaA:
undetectable		 3a6jB-4gaaA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.91A 3a6jC-4gaaA:
undetectable		 3a6jC-4gaaA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.93A 3a6jE-4gaaA:
undetectable		 3a6jE-4gaaA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.90A 3a6jF-4gaaA:
undetectable		 3a6jF-4gaaA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 4 ILE A 217
ARG A 560
ILE A 257
THR A 215
 None
BES  A 702 (-4.0A)
None
None
 1.09A 3ia4C-4gaaA:
undetectable		 3ia4C-4gaaA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		3 / 3 HIS A 353
GLU A 354
HIS A 357
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
 0.17A 3kecB-2yd0A:
4.8		 3kecB-2yd0A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		3 / 3 HIS A 393
GLU A 394
HIS A 397
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
 0.21A 3kecB-4kxbA:
4.6		 3kecB-4kxbA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 7 GLU A 354
TYR A 245
PHE A 314
TYR A 327
 BES  A1950 (-3.3A)
None
None
None
 1.31A 3ku9B-2yd0A:
undetectable		 3ku9B-2yd0A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 11 HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.78A 4c2pA-2yd0A:
undetectable		 4c2pA-2yd0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 11 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.68A 4c2pA-4gaaA:
3.0		 4c2pA-4gaaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 11 HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.81A 4c2pA-4kxbA:
3.1		 4c2pA-4kxbA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 9 GLY A 317
HIS A 353
GLU A 354
GLU A 376
TYR A 438
 BES  A1950 (-3.7A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 0.36A 4dprA-2yd0A:
32.3		 4dprA-2yd0A:
21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		8 / 9 TYR A 264
GLY A 265
HIS A 292
GLU A 293
GLU A 315
TYR A 380
ARG A 560
LYS A 562
 BES  A 702 (-3.3A)
BES  A 702 (-3.2A)
ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
BES  A 702 (-4.0A)
BES  A 702 ( 4.7A)
 0.54A 4dprA-4gaaA:
55.9		 4dprA-4gaaA:
67.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 9 TYR A 264
GLY A 266
HIS A 292
GLU A 315
TYR A 380
 BES  A 702 (-3.3A)
BES  A 702 (-4.3A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 1.03A 4dprA-4gaaA:
55.9		 4dprA-4gaaA:
67.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 9 GLY A 357
HIS A 393
GLU A 394
GLU A 416
TYR A 479
 BES  A1017 (-3.0A)
ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.45A 4dprA-4kxbA:
31.4		 4dprA-4kxbA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		4 / 7 ASP A 132
GLU A 167
HIS A 445
GLU A 166
 MN  A 503 (-2.4A)
MN  A 503 (-1.9A)
MN  A 503 ( 3.3A)
BES  A 501 (-2.9A)
 1.09A 4hvrA-4ruhA:
undetectable		 4hvrA-4ruhA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 LEU A 445
HIS A 357
HIS A 353
GLU A 376
 None
BES  A1950 ( 3.3A)
ZN  A1946 ( 3.3A)
ZN  A1946 ( 2.1A)
 0.99A 4pahA-2yd0A:
undetectable		 4pahA-2yd0A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4ruh CYTOSOLIC
NON-SPECIFIC
DIPEPTIDASE
(Homo
sapiens) 		7 / 11 HIS A  99
ASP A 132
GLU A 166
GLU A 167
GLY A 415
GLY A 416
HIS A 445
 MN  A 502 ( 3.6A)
MN  A 503 (-2.4A)
BES  A 501 (-2.9A)
MN  A 503 (-1.9A)
None
BES  A 501 (-3.6A)
MN  A 503 ( 3.3A)
 0.64A 4pqaA-4ruhA:
33.6		 4pqaA-4ruhA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		7 / 12 HIS A 353
GLU A 354
HIS A 357
TRP A 369
PHE A 433
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
None
BES  A1950 ( 4.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
 1.31A 4r7lA-2yd0A:
43.9		 4r7lA-2yd0A:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		11 / 12 GLN A 133
ALA A 134
TYR A 264
HIS A 292
GLU A 293
HIS A 296
TRP A 308
PHE A 311
GLU A 315
LEU A 366
TYR A 380
 BES  A 702 (-3.2A)
BES  A 702 ( 4.4A)
BES  A 702 (-3.3A)
ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
None
BES  A 702 ( 4.9A)
ZN  A 701 ( 1.7A)
None
BES  A 702 (-4.3A)
 0.47A 4r7lA-4gaaA:
56.3		 4r7lA-4gaaA:
65.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 12 GLU A 394
HIS A 397
TRP A 409
PHE A 474
GLU A 416
 BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
None
BES  A1017 (-3.7A)
ZN  A1001 ( 2.4A)
 1.41A 4r7lA-4kxbA:
40.5		 4r7lA-4kxbA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		6 / 12 HIS A 393
GLU A 394
HIS A 397
TRP A 409
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
None
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
 0.41A 4r7lA-4kxbA:
40.5		 4r7lA-4kxbA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 ASN A 269
MET A 267
TRP A 250
TYR A 248
 None
BES  A 702 (-3.4A)
None
None
 1.49A 4v30B-4gaaA:
undetectable		 4v30B-4gaaA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		4 / 5 GLU A 360
ALA A 358
GLU A 394
GLU A 416
 BES  A1017 (-2.9A)
BES  A1017 (-4.6A)
BES  A1017 (-3.1A)
ZN  A1001 ( 2.4A)
 1.36A 5dwkC-4kxbA:
undetectable		 5dwkC-4kxbA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 4 HIS A 296
HIS A 292
TYR A 380
GLU A 315
 ZN  A 701 ( 3.4A)
ZN  A 701 ( 3.2A)
BES  A 702 (-4.3A)
ZN  A 701 ( 1.7A)
 1.40A 5pahA-4gaaA:
undetectable		 5pahA-4gaaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 GLY A 377
ALA A 442
PHE A 360
TYR A 293
GLU A 354
 None
None
None
None
BES  A1950 (-3.3A)
 1.42A 5wbvA-2yd0A:
undetectable		 5wbvA-2yd0A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		5 / 12 GLY A 377
ALA A 442
PHE A 360
TYR A 293
GLU A 354
 None
None
None
None
BES  A1950 (-3.3A)
 1.42A 5wbvB-2yd0A:
undetectable		 5wbvB-2yd0A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 10 ALA A 287
LEU A 255
TYR A 253
VAL A 275
GLY A 266
 None
None
None
None
BES  A 702 (-4.3A)
 1.28A 5zbdA-4gaaA:
undetectable		 5zbdA-4gaaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		3 / 3 GLN A 133
TRP A 308
VAL A 371
 BES  A 702 (-3.2A)
None
None
 0.94A 6auuA-4gaaA:
undetectable		 6auuA-4gaaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens) 		5 / 9 ALA A 419
SER A 420
VAL A 390
ALA A 392
GLY A 426
 ZN  A1001 ( 4.2A)
None
BES  A1017 ( 3.7A)
None
None
 1.10A 6bklA-4kxbA:
undetectable
6bklB-4kxbA:
undetectable
6bklC-4kxbA:
undetectable
6bklD-4kxbA:
undetectable		 6bklA-4kxbA:
3.10
6bklB-4kxbA:
3.10
6bklC-4kxbA:
3.10
6bklD-4kxbA:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_1
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 ASN A 218
GLN A 181
TYR A 438
MET A 242
 None
BES  A1950 (-4.1A)
BES  A1950 (-4.3A)
None
 0.88A 6hlpA-2yd0A:
0.0		 6hlpA-2yd0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 5 GLN A 358
GLU A 354
ASN A 375
TYR A 293
 None
BES  A1950 (-3.3A)
None
None
 1.36A 6iftA-2yd0A:
undetectable		 6iftA-2yd0A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens) 		4 / 6 LEU A 445
HIS A 357
HIS A 353
GLU A 376
 None
BES  A1950 ( 3.3A)
ZN  A1946 ( 3.3A)
ZN  A1946 ( 2.1A)
 1.01A 6pahA-2yd0A:
undetectable		 6pahA-2yd0A:
15.70