SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BEM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 6 TRP A 270
TYR A 395
ILE A 385
TYR A 379
 BEM  A 494 ( 3.8A)
BEM  A 494 (-4.6A)
None
None
 1.15A 1maaB-1y3nA:
undetectable
1maaD-1y3nA:
undetectable		 1maaB-1y3nA:
21.56
1maaD-1y3nA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 6 TRP A 270
TYR A 395
ILE A 385
TYR A 379
 BEM  A 502 ( 3.6A)
MAW  A 501 ( 4.5A)
None
None
 1.11A 1maaB-5h71A:
undetectable
1maaD-5h71A:
undetectable		 1maaB-5h71A:
20.50
1maaD-5h71A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 TYR A 257
HIS A 202
MET A 264
PRO A 265
ASN A 441
 BEM  A 804 (-4.8A)
MAV  A 803 (-3.8A)
None
None
BEM  A 804 ( 4.7A)
 1.47A 1mrlB-4ojzA:
undetectable
1mrlC-4ojzA:
undetectable		 1mrlB-4ojzA:
14.40
1mrlC-4ojzA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 5h71 ALGQ2
(Sphingomonas
sp.) 		5 / 12 GLY A  84
GLY A  87
ASP A  78
ASP A  74
GLY A  73
 None
None
None
BEM  A 503 ( 3.7A)
None
 1.02A 1sqfA-5h71A:
undetectable		 1sqfA-5h71A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_F_SAMF501_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 6 ASN A 278
ASN A 401
TRP A 399
TRP A 270
 None
None
None
BEM  A 494 ( 3.8A)
 1.11A 2c2bC-1y3nA:
0.0
2c2bE-1y3nA:
0.0
2c2bF-1y3nA:
0.0		 2c2bC-1y3nA:
20.53
2c2bE-1y3nA:
20.53
2c2bF-1y3nA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 TYR A 261
GLU A  87
HIS A  86
GLY A  82
 BEM  A 804 (-3.6A)
None
None
None
 1.16A 2ha4B-4ojzA:
undetectable		 2ha4B-4ojzA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_A_VIBA500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 5h71 ALGQ2
(Sphingomonas
sp.) 		5 / 10 ASN A  75
ASP A 206
TRP A 270
TYR A 129
ASP A 315
 BEM  A 503 ( 3.6A)
None
BEM  A 502 ( 3.6A)
BEM  A 502 ( 4.4A)
BEM  A 503 ( 4.9A)
 1.44A 3myuA-5h71A:
4.6		 3myuA-5h71A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 TRP A 145
HIS A  86
ASN A 441
TYR A 450
 None
None
BEM  A 804 ( 4.7A)
LGU  A 802 (-4.4A)
 1.35A 4a3uA-4ojzA:
undetectable		 4a3uA-4ojzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 TRP A 145
HIS A  86
ASN A 441
TYR A 450
 None
None
BEM  A 804 ( 4.7A)
LGU  A 802 (-4.4A)
 1.40A 4a3uB-4ojzA:
undetectable		 4a3uB-4ojzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 TRP A 145
HIS A  86
ASN A 441
LEU A 440
 None
None
BEM  A 804 ( 4.7A)
None
 1.39A 4awuA-4ojzA:
undetectable		 4awuA-4ojzA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 7 ASP A  74
ASP A  21
TRP A  23
SER A  54
 BEM  A 503 ( 3.7A)
None
None
None
 1.20A 4k7gB-5h71A:
undetectable		 4k7gB-5h71A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 5 TYR A 129
GLN A 391
ASP A 206
ASP A 189
 BEM  A 502 ( 4.4A)
MAW  A 501 ( 3.7A)
None
None
 1.47A 4qtuB-5h71A:
undetectable		 4qtuB-5h71A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.42A 5a06A-1y3nA:
undetectable		 5a06A-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 BEM  A 502 ( 4.2A)
MAW  A 501 ( 4.8A)
None
None
 1.40A 5a06A-5h71A:
undetectable		 5a06A-5h71A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.41A 5a06C-1y3nA:
undetectable		 5a06C-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 BEM  A 502 ( 4.2A)
MAW  A 501 ( 4.8A)
None
None
 1.40A 5a06C-5h71A:
undetectable		 5a06C-5h71A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.41A 5a06D-1y3nA:
undetectable		 5a06D-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 BEM  A 502 ( 4.2A)
MAW  A 501 ( 4.8A)
None
None
 1.39A 5a06D-5h71A:
undetectable		 5a06D-5h71A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.42A 5a06E-1y3nA:
undetectable		 5a06E-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 BEM  A 502 ( 4.2A)
MAW  A 501 ( 4.8A)
None
None
 1.40A 5a06E-5h71A:
undetectable		 5a06E-5h71A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 MAV  A 495 (-4.1A)
BEM  A 494 ( 4.8A)
None
None
 1.39A 5a06F-1y3nA:
undetectable		 5a06F-1y3nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5h71 ALGQ2
(Sphingomonas
sp.) 		4 / 7 ARG A  20
ARG A 255
ASP A 269
TYR A 379
 BEM  A 502 ( 4.2A)
MAW  A 501 ( 4.8A)
None
None
 1.36A 5a06F-5h71A:
undetectable		 5a06F-5h71A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5h71 ALGQ2
(Sphingomonas
sp.) 		3 / 3 ARG A 193
HIS A 187
ARG A 137
 None
BEM  A 503 ( 3.9A)
BEM  A 502 ( 3.7A)
 1.06A 5iaoC-5h71A:
undetectable		 5iaoC-5h71A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5h71 ALGQ2
(Sphingomonas
sp.) 		3 / 3 ARG A 193
HIS A 187
ARG A 137
 None
BEM  A 503 ( 3.9A)
BEM  A 502 ( 3.7A)
 1.06A 5iaoF-5h71A:
undetectable		 5iaoF-5h71A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1y3n ALGQ1
(Sphingomonas
sp.
A1) 		4 / 5 TYR A 393
GLN A 391
GLY A 138
ILE A 408
 None
BEM  A 494 (-3.6A)
None
None
 1.39A 6debB-1y3nA:
undetectable		 6debB-1y3nA:
9.53