SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BDR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Hahella
chejuensis) 		4 / 8 LEU A 171
ARG A 183
PHE A 187
GLY A 149
 None
BDR  A   1 (-3.2A)
None
None
 0.91A 1fapB-3ksmA:
undetectable		 1fapB-3ksmA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_1
(HYPOTHETICAL PROTEIN
PH0226)		 5tsq IUNH
(Leishmania
braziliensis) 		4 / 4 TYR A 229
ARG A 233
ASP A 241
ASP A   8
 None
None
BDR  A 402 ( 2.5A)
None
 1.26A 1ve3A-5tsqA:
2.7		 1ve3A-5tsqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_1
(HYPOTHETICAL PROTEIN
PH0226)		 5tsq IUNH
(Leishmania
braziliensis) 		4 / 4 TYR A 229
ARG A 233
ASP A 241
ASP A   8
 None
None
BDR  A 402 ( 2.5A)
None
 1.30A 1ve3B-5tsqA:
3.3		 1ve3B-5tsqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 5tsq IUNH
(Leishmania
braziliensis) 		6 / 12 ASP A  14
GLY A  12
ALA A  78
GLN A  80
GLY A 127
ASP A  10
 BDR  A 402 (-2.8A)
BDR  A 402 ( 4.9A)
None
None
CA  A 401 ( 4.2A)
CA  A 401 (-3.1A)
 1.40A 2pkkA-5tsqA:
undetectable		 2pkkA-5tsqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 5tsq IUNH
(Leishmania
braziliensis) 		6 / 12 ASP A  14
GLY A  12
ALA A  78
GLN A  80
GLY A 127
ASP A  10
 BDR  A 402 (-2.8A)
BDR  A 402 ( 4.9A)
None
None
CA  A 401 ( 4.2A)
CA  A 401 (-3.1A)
 1.38A 2pkmA-5tsqA:
5.5		 2pkmA-5tsqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Hahella
chejuensis) 		4 / 8 SER A  49
ASN A  50
ASP A 207
ARG A 174
 None
BDR  A   1 ( 4.3A)
None
None
 1.12A 2v57A-3ksmA:
undetectable		 2v57A-3ksmA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Hahella
chejuensis) 		4 / 8 SER A  49
ASN A  50
ASP A 207
ARG A 174
 None
BDR  A   1 ( 4.3A)
None
None
 1.12A 2v57C-3ksmA:
undetectable		 2v57C-3ksmA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 5tsq IUNH
(Leishmania
braziliensis) 		3 / 3 ARG A  76
PRO A  79
PHE A 167
 None
None
BDR  A 402 (-4.6A)
 1.01A 3thrC-5tsqA:
undetectable		 3thrC-5tsqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 12 ASP A 241
PRO A  11
ILE A 169
MET A 152
ASP A  10
 BDR  A 402 ( 2.5A)
None
None
BDR  A 402 ( 3.7A)
CA  A 401 (-3.1A)
 1.41A 3topA-5tsqA:
undetectable		 3topA-5tsqA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 11 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.38A 5fctA-5tsqA:
undetectable		 5fctA-5tsqA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Hahella
chejuensis) 		3 / 3 PRO A 232
ARG A 183
GLU A 184
 None
BDR  A   1 (-3.2A)
None
 0.82A 5j6hA-3ksmA:
undetectable		 5j6hA-3ksmA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Hahella
chejuensis) 		4 / 5 ASN A 106
ASP A  79
ASN A  50
ASP A 259
 None
None
BDR  A   1 ( 4.3A)
BDR  A   1 (-2.7A)
 1.30A 5vooA-3ksmA:
2.9		 5vooA-3ksmA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Hahella
chejuensis) 		4 / 5 ASN A 106
ASP A  79
ASN A  50
ASP A 259
 None
None
BDR  A   1 ( 4.3A)
BDR  A   1 (-2.7A)
 1.31A 5vooC-3ksmA:
undetectable		 5vooC-3ksmA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT
(Hahella
chejuensis) 		4 / 5 ASN A 106
ASP A  79
ASN A  50
ASP A 259
 None
None
BDR  A   1 ( 4.3A)
BDR  A   1 (-2.7A)
 1.30A 5vooE-3ksmA:
undetectable		 5vooE-3ksmA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 10 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.40A 6r2eB-5tsqA:
undetectable		 6r2eB-5tsqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 10 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.40A 6r2eC-5tsqA:
undetectable		 6r2eC-5tsqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 10 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.34A 6r2eD-5tsqA:
undetectable		 6r2eD-5tsqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 11 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.36A 6r2eF-5tsqA:
undetectable		 6r2eF-5tsqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 11 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.34A 6r2eG-5tsqA:
undetectable		 6r2eG-5tsqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 12 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.29A 6r2eH-5tsqA:
undetectable		 6r2eH-5tsqA:
21.29