SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BCO'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_A_KLNA1501_1 (CYTOCHROME P450 3A4)	5cju	ISOBUTYRYL-COA MUTASE FUSED (Cupriavidus metallidurans)	5 / 10	ASP A 880 SER A 624 LEU A 885 THR A 884 GLY A 868	None BCO A1103 (-3.4A) None None 5AD A1102 ( 3.5A)	1.33A	2v0mA-5cjuA: undetectable	2v0mA-5cjuA: 18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X0P_A_ADNA1607_1 (ALCALIGIN BIOSYNTHESIS PROTEIN)	5cju	ISOBUTYRYL-COA MUTASE FUSED (Cupriavidus metallidurans)	4 / 8	GLY A 741 HIS A 780 ASN A 798 ALA A 784	None BCO A1103 ( 3.8A) None B12 A1101 (-3.7A)	0.83A	2x0pA-5cjuA: undetectable	2x0pA-5cjuA: 22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_A_CHDA153_0 (ILEAL BILE ACID-BINDING PROTEIN)	5cju	ISOBUTYRYL-COA MUTASE FUSED (Cupriavidus metallidurans)	4 / 5	ILE A 776 THR A 730 PHE A 771 PHE A 763	None BCO A1103 (-3.2A) None None	1.28A	3em0A-5cjuA: undetectable	3em0A-5cjuA: 8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IK3_B_0LIB2_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	5cju	ISOBUTYRYL-COA MUTASE FUSED (Cupriavidus metallidurans)	4 / 7	LEU A 736 VAL A 768 ILE A 759 ARG A 728	None None None BCO A1103 (-3.6A)	1.19A	3ik3B-5cjuA: undetectable	3ik3B-5cjuA: 13.13

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2V0M_A_KLNA1501_1","CYTOCHROME P450 3A4","5cju","ISOBUTYRYL-COA MUTASE FUSED","Cupriavidus metallidurans",5,"ASP A 880;SER A 624;LEU A 885;THR A 884;GLY A 868","None;BCO A1103 (-3.4A);None;None;5AD A1102 ( 3.5A)","1.33A","2v0mA-5cjuA:undetectable",null],["2X0P_A_ADNA1607_1","ALCALIGIN BIOSYNTHESIS PROTEIN","5cju","ISOBUTYRYL-COA MUTASE FUSED","Cupriavidus metallidurans",4,"GLY A 741;HIS A 780;ASN A 798;ALA A 784","None;BCO A1103 ( 3.8A);None;B12 A1101 (-3.7A)","0.83A","2x0pA-5cjuA:undetectable","2v0mA-5cjuA:18.42"],["3EM0_A_CHDA153_0","ILEAL BILE ACID-BINDING PROTEIN","5cju","ISOBUTYRYL-COA MUTASE FUSED","Cupriavidus metallidurans",4,"ILE A 776;THR A 730;PHE A 771;PHE A 763","None;BCO A1103 (-3.2A);None;None","1.28A","3em0A-5cjuA:undetectable","2x0pA-5cjuA:22.11"],["3IK3_B_0LIB2_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","5cju","ISOBUTYRYL-COA MUTASE FUSED","Cupriavidus metallidurans",4,"LEU A 736;VAL A 768;ILE A 759;ARG A 728","None;None;None;BCO A1103 (-3.6A)","1.19A","3ik3B-5cjuA:undetectable","3em0A-5cjuA:8.83"]]