SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BB2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4dr9 PEPTIDE DEFORMYLASE
(Synechococcus
elongatus) 		5 / 12 ILE A  60
GLY A  61
LEU A 139
LEU A  90
TYR A 129
 BB2  A 203 (-4.1A)
BB2  A 203 (-4.4A)
None
None
None
 1.47A 1fm6X-4dr9A:
undetectable		 1fm6X-4dr9A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		5 / 10 ALA A  69
VAL A  71
HIS A 174
GLU A 175
HIS A 178
 None
BB2  A 400 ( 3.8A)
CO  A 300 ( 3.6A)
BB2  A 400 (-2.8A)
CO  A 300 ( 3.4A)
 0.56A 1r55A-2os3A:
undetectable		 1r55A-2os3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 3g5k PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 113
ILE A 167
HIS A 160
HIS A 156
VAL A 117
 BB2  A1001 (-3.7A)
None
CO  A1002 ( 3.3A)
CO  A1002 ( 3.2A)
None
 1.25A 1tmxB-3g5kA:
undetectable		 1tmxB-3g5kA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 3u04 PEPTIDE DEFORMYLASE
1
(Ehrlichia
chaffeensis) 		4 / 8 LEU A  45
HIS A 153
GLU A 154
HIS A 157
 BB2  A 210 (-4.1A)
ZN  A 200 ( 3.3A)
BB2  A 210 (-2.7A)
ZN  A 200 ( 3.3A)
 0.23A 2jihB-3u04A:
undetectable		 2jihB-3u04A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		4 / 8 LEU A 205
ARG A 144
VAL A  87
GLY A  72
 None
None
None
BB2  A 400 (-4.6A)
 0.87A 2po5B-2os3A:
undetectable		 2po5B-2os3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 2os1 PEPTIDE DEFORMYLASE
(Enterococcus
faecalis) 		5 / 10 LEU A 188
ILE A 153
ARG A 127
VAL A  75
GLY A  60
 BB2  A 400 (-4.4A)
BB2  A 400 (-4.4A)
None
None
BB2  A 400 (-4.4A)
 1.18A 2qd4B-2os1A:
undetectable		 2qd4B-2os1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		5 / 10 LEU A 205
ILE A 170
ARG A 144
VAL A  87
GLY A  72
 None
BB2  A 400 ( 4.9A)
None
None
BB2  A 400 (-4.6A)
 1.21A 2qd4B-2os3A:
0.0		 2qd4B-2os3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		4 / 8 LEU A 205
ARG A 144
VAL A  87
GLY A  72
 None
None
None
BB2  A 400 (-4.6A)
 0.74A 2qd5B-2os3A:
undetectable		 2qd5B-2os3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5nsq AMINOPEPTIDASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 ALA A 405
GLY A 416
GLY A 476
HIS A 493
LEU A 417
 BB2  A 603 (-4.2A)
None
None
None
None
 0.99A 2x1lB-5nsqA:
2.3		 2x1lB-5nsqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1lqy PEPTIDE DEFORMYLASE
2
(Geobacillus
stearothermophil
us) 		4 / 7 ILE A 149
VAL A 121
TYR A 124
CYH A 102
 BB2  A 401 ( 4.9A)
None
None
None
 1.34A 2xz5D-1lqyA:
undetectable
2xz5E-1lqyA:
undetectable		 2xz5D-1lqyA:
22.22
2xz5E-1lqyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 1lry PEPTIDE DEFORMYLASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A  62
GLU A 134
ILE A 131
 None
BB2  A 170 (-2.6A)
None
 0.59A 3czhA-1lryA:
0.0		 3czhA-1lryA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3u04 PEPTIDE DEFORMYLASE
1
(Ehrlichia
chaffeensis) 		5 / 12 MET A  35
LEU A  47
GLY A  46
LEU A 158
ILE A  92
 None
None
BB2  A 210 (-4.6A)
None
None
 1.28A 3h52A-3u04A:
undetectable		 3h52A-3u04A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 1lry PEPTIDE DEFORMYLASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 133
GLU A 134
HIS A 137
 ZN  A 168 ( 3.4A)
BB2  A 170 (-2.6A)
ZN  A 168 ( 3.5A)
 0.19A 3kecB-1lryA:
undetectable		 3kecB-1lryA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		3 / 3 HIS A 174
GLU A 175
HIS A 178
 CO  A 300 ( 3.6A)
BB2  A 400 (-2.8A)
CO  A 300 ( 3.4A)
 0.22A 3kecB-2os3A:
undetectable		 3kecB-2os3A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3g5k PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 HIS A 156
GLU A 157
HIS A 160
 CO  A1002 ( 3.2A)
BB2  A1001 (-2.6A)
CO  A1002 ( 3.3A)
 0.19A 3kecB-3g5kA:
undetectable		 3kecB-3g5kA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 3u04 PEPTIDE DEFORMYLASE
1
(Ehrlichia
chaffeensis) 		3 / 3 HIS A 153
GLU A 154
HIS A 157
 ZN  A 200 ( 3.3A)
BB2  A 210 (-2.7A)
ZN  A 200 ( 3.3A)
 0.22A 3kecB-3u04A:
undetectable		 3kecB-3u04A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4dr9 PEPTIDE DEFORMYLASE
(Synechococcus
elongatus) 		3 / 3 HIS A 151
GLU A 152
HIS A 155
 ZN  A 201 ( 3.3A)
BB2  A 203 (-2.6A)
ZN  A 201 ( 3.3A)
 0.14A 3kecB-4dr9A:
undetectable		 3kecB-4dr9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4wxl PEPTIDE DEFORMYLASE
(Haemophilus
influenzae) 		3 / 3 HIS A 133
GLU A 134
HIS A 137
 NI  A 201 ( 3.3A)
BB2  A 202 (-2.8A)
NI  A 201 ( 3.2A)
 0.17A 3kecB-4wxlA:
undetectable		 3kecB-4wxlA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		5 / 12 LEU A  27
ILE A  78
HIS A 174
VAL A 138
GLU A 175
 None
None
CO  A 300 ( 3.6A)
None
BB2  A 400 (-2.8A)
 1.13A 3w1wB-2os3A:
undetectable		 3w1wB-2os3A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2os1 PEPTIDE DEFORMYLASE
(Enterococcus
faecalis) 		4 / 5 LEU A  41
HIS A 157
GLU A 158
HIS A 161
 None
NI  A 300 ( 3.5A)
BB2  A 400 (-2.6A)
NI  A 300 ( 3.5A)
 0.84A 4a7bB-2os1A:
undetectable		 4a7bB-2os1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		4 / 5 LEU A  53
HIS A 174
GLU A 175
HIS A 178
 None
CO  A 300 ( 3.6A)
BB2  A 400 (-2.8A)
CO  A 300 ( 3.4A)
 0.84A 4a7bB-2os3A:
undetectable		 4a7bB-2os3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1lqy PEPTIDE DEFORMYLASE
2
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  60
ALA A  74
ARG A 123
GLU A 108
HIS A 157
 BB2  A 401 (-4.4A)
None
None
BB2  A 401 ( 3.9A)
NI  A 301 ( 3.4A)
 1.15A 4azsA-1lqyA:
undetectable		 4azsA-1lqyA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 2okl PEPTIDE DEFORMYLASE
2
(Bacillus
cereus) 		5 / 12 GLY A  60
ALA A  74
ARG A 123
GLU A 108
HIS A 157
 BB2  A 401 (-4.7A)
None
None
BB2  A 401 (-3.8A)
ZN  A 601 ( 3.4A)
 1.18A 4azsA-2oklA:
undetectable		 4azsA-2oklA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 2os1 PEPTIDE DEFORMYLASE
(Enterococcus
faecalis) 		5 / 12 GLY A  60
ALA A  74
ARG A 127
GLU A 112
HIS A 161
 BB2  A 400 (-4.4A)
None
None
BB2  A 400 ( 3.9A)
NI  A 300 ( 3.5A)
 1.09A 4azsA-2os1A:
undetectable		 4azsA-2os1A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		5 / 12 ASP A 513
GLY A 422
GLY A 489
SER A 490
HIS A 315
 None
BB2  A 604 (-3.8A)
None
None
BB2  A 604 (-3.5A)
 1.17A 4blvB-5nthA:
undetectable		 4blvB-5nthA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		5 / 12 PRO A 152
GLY A 162
PHE A 161
GLY A  98
TYR A 151
 None
None
None
BB2  A 202 (-2.7A)
None
 1.17A 4lxzA-5i2bA:
undetectable		 4lxzA-5i2bA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		5 / 12 PRO A 152
GLY A 162
PHE A 161
GLY A  98
TYR A 151
 None
None
None
BB2  A 202 (-2.7A)
None
 1.15A 4lxzC-5i2bA:
undetectable		 4lxzC-5i2bA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3m6q PEPTIDE DEFORMYLASE
1B
(Arabidopsis
thaliana) 		4 / 6 PHE A  58
MET A  56
ILE A 130
VAL A 107
 None
None
BB2  A 194 (-4.1A)
None
 1.35A 4mk4B-3m6qA:
undetectable		 4mk4B-3m6qA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 5nth PUTATIVE
AMINOPEPTIDASE
(Leishmania
major) 		3 / 3 LYS A 311
LYS A 299
ALA A 390
 BB2  A 604 ( 2.6A)
MN  A 602 ( 2.0A)
BCT  A 601 (-3.6A)
 1.14A 4ot2A-5nthA:
1.0		 4ot2A-5nthA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		4 / 8 HIS A 145
GLU A 142
ASP A 144
ARG A 154
 ZN  A 201 ( 3.5A)
BB2  A 202 (-2.2A)
EDO  A 203 ( 4.8A)
EDO  A 203 (-2.8A)
 1.17A 4uhxA-5i2bA:
undetectable		 4uhxA-5i2bA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		4 / 8 HIS A 145
GLU A 142
ASP A 144
ARG A 154
 ZN  A 201 ( 3.5A)
BB2  A 202 (-2.2A)
EDO  A 203 ( 4.8A)
EDO  A 203 (-2.8A)
 1.17A 4uhxA-5i2bA:
undetectable		 4uhxA-5i2bA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3g5k PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A 157
HIS A 156
ARG A 152
 BB2  A1001 (-2.6A)
CO  A1002 ( 3.2A)
None
 0.94A 5uunA-3g5kA:
undetectable		 5uunA-3g5kA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4dr9 PEPTIDE DEFORMYLASE
(Synechococcus
elongatus) 		3 / 3 GLU A 152
HIS A 151
ARG A 147
 BB2  A 203 (-2.6A)
ZN  A 201 ( 3.3A)
None
 0.95A 5uunA-4dr9A:
undetectable		 5uunA-4dr9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		3 / 3 GLU A 142
HIS A 141
ARG A 137
 BB2  A 202 (-2.2A)
BB2  A 202 ( 2.4A)
None
 0.93A 5uunA-5i2bA:
undetectable		 5uunA-5i2bA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5i2b PEPTIDE DEFORMYLASE
(Burkholderia
ambifaria) 		3 / 3 HIS A 145
HIS A 141
ARG A 111
 ZN  A 201 ( 3.5A)
BB2  A 202 ( 2.4A)
EDO  A 203 ( 4.7A)
 1.13A 6b58A-5i2bA:
undetectable		 6b58A-5i2bA:
17.71