SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BAT'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		5 / 10 ASP A 345
ILE A 368
GLY A 369
GLY A 360
GLU A 358
 K  A1007 (-4.2A)
BAT  A1000 ( 4.4A)
NA  A1003 ( 4.9A)
None
NA  A1003 ( 3.9A)
 1.31A 1mehA-4dd8A:
undetectable		 1mehA-4dd8A:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 5 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.22A 1os2A-1rm8A:
27.6		 1os2A-1rm8A:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 5 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.17A 1os2A-2rjqA:
10.2		 1os2A-2rjqA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 5 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.42A 1os2A-4dd8A:
10.0		 1os2A-4dd8A:
23.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.17A 1os2D-1rm8A:
27.7		 1os2D-1rm8A:
51.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.16A 1os2D-2rjqA:
10.3		 1os2D-2rjqA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 4 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.42A 1os2D-4dd8A:
10.0		 1os2D-4dd8A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2rjq ADAMTS-5
(Homo
sapiens) 		6 / 10 THR A 378
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
 BAT  A 559 ( 4.1A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.46A 1r55A-2rjqA:
25.4		 1r55A-2rjqA:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R55_A_097A518_1
(ADAM 33)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		7 / 10 THR A 300
VAL A 301
THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
 BAT  A1000 (-3.2A)
BAT  A1000 (-3.8A)
BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.32A 1r55A-4dd8A:
31.1		 1r55A-4dd8A:
43.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.22A 1uttA-1rm8A:
28.0		 1uttA-1rm8A:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.19A 1uttA-2rjqA:
10.6		 1uttA-2rjqA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 4 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.39A 1uttA-4dd8A:
10.4		 1uttA-4dd8A:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.17A 1utzA-1rm8A:
28.2		 1utzA-1rm8A:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.19A 1utzA-2rjqA:
10.4		 1utzA-2rjqA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 4 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.40A 1utzA-4dd8A:
10.2		 1utzA-4dd8A:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.19A 1utzB-1rm8A:
28.3		 1utzB-1rm8A:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.20A 1utzB-2rjqA:
10.5		 1utzB-2rjqA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 4 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.43A 1utzB-4dd8A:
10.3		 1utzB-4dd8A:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 6 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.18A 1y93A-1rm8A:
28.1		 1y93A-1rm8A:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 6 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.16A 1y93A-2rjqA:
10.5		 1y93A-2rjqA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 6 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.40A 1y93A-4dd8A:
10.3		 1y93A-4dd8A:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.15A 2hu6A-1rm8A:
28.2		 2hu6A-1rm8A:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.12A 2hu6A-2rjqA:
10.4		 2hu6A-2rjqA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 4 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.37A 2hu6A-4dd8A:
10.4		 2hu6A-4dd8A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 9 LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.30A 2jihA-1rm8A:
10.3		 2jihA-1rm8A:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		 2rjq ADAMTS-5
(Homo
sapiens) 		6 / 9 ASP A 377
LEU A 379
THR A 407
GLU A 411
HIS A 414
LEU A 443
 BAT  A 559 (-3.7A)
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
 1.01A 2jihA-2rjqA:
40.4		 2jihA-2rjqA:
48.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_A_097A1001_1
(ADAMTS-1)		 2rjq ADAMTS-5
(Homo
sapiens) 		7 / 9 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
 BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
 0.75A 2jihA-2rjqA:
40.4		 2jihA-2rjqA:
48.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		5 / 9 THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
 BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.36A 2jihA-4dd8A:
26.4		 2jihA-4dd8A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 8 LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.28A 2jihB-1rm8A:
9.8		 2jihB-1rm8A:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		 2rjq ADAMTS-5
(Homo
sapiens) 		6 / 8 LEU A 379
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
 BAT  A 559 (-4.0A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
 0.57A 2jihB-2rjqA:
40.2		 2jihB-2rjqA:
48.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JIH_B_097B1001_1
(ADAMTS-1)		 2rjq ADAMTS-5
(Homo
sapiens) 		6 / 8 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
 BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.26A 2jihB-2rjqA:
40.2		 2jihB-2rjqA:
48.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		5 / 8 THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
 BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.38A 2jihB-4dd8A:
26.2		 2jihB-4dd8A:
28.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 6 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.27A 2ow9A-1rm8A:
27.1		 2ow9A-1rm8A:
47.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 6 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.19A 2ow9A-2rjqA:
10.0		 2ow9A-2rjqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 6 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.40A 2ow9A-4dd8A:
10.1		 2ow9A-4dd8A:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.17A 2ow9B-1rm8A:
26.9		 2ow9B-1rm8A:
47.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.19A 2ow9B-2rjqA:
9.9		 2ow9B-2rjqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 4 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.40A 2ow9B-4dd8A:
9.9		 2ow9B-4dd8A:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.20A 2ozrC-1rm8A:
27.2		 2ozrC-1rm8A:
47.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.22A 2ozrC-2rjqA:
9.6		 2ozrC-2rjqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 4 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.44A 2ozrC-4dd8A:
9.7		 2ozrC-4dd8A:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.18A 2ozrD-1rm8A:
27.4		 2ozrD-1rm8A:
47.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.23A 2ozrD-2rjqA:
9.8		 2ozrD-2rjqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 4 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.40A 2ozrD-4dd8A:
9.8		 2ozrD-4dd8A:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.22A 2ozrE-1rm8A:
26.8		 2ozrE-1rm8A:
47.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.25A 2ozrE-2rjqA:
10.0		 2ozrE-2rjqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 4 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.42A 2ozrE-4dd8A:
9.9		 2ozrE-4dd8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		3 / 3 HIS A 208
GLU A 247
HIS A 250
 ZN  A 501 (-3.2A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
 0.55A 3ba0A-1rm8A:
25.5		 3ba0A-1rm8A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 9 LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.34A 3hy7A-1rm8A:
10.7		 3hy7A-1rm8A:
26.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2rjq ADAMTS-5
(Homo
sapiens) 		6 / 9 ASP A 377
LEU A 379
THR A 407
GLU A 411
HIS A 414
HIS A 420
 BAT  A 559 (-3.7A)
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.69A 3hy7A-2rjqA:
36.9		 3hy7A-2rjqA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2rjq ADAMTS-5
(Homo
sapiens) 		7 / 9 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
ILE A 442
 BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.3A)
 0.46A 3hy7A-2rjqA:
36.9		 3hy7A-2rjqA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		5 / 9 THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
 BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.37A 3hy7A-4dd8A:
26.2		 3hy7A-4dd8A:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 9 LEU A 206
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 BAT  A 800 (-3.8A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.29A 3hy7B-1rm8A:
10.6		 3hy7B-1rm8A:
26.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2rjq ADAMTS-5
(Homo
sapiens) 		8 / 9 ASP A 377
LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
LEU A 443
 BAT  A 559 (-3.7A)
BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.2A)
 0.75A 3hy7B-2rjqA:
35.7		 3hy7B-2rjqA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 2rjq ADAMTS-5
(Homo
sapiens) 		8 / 9 LEU A 379
THR A 407
HIS A 410
GLU A 411
HIS A 414
HIS A 420
ILE A 442
LEU A 443
 BAT  A 559 (-4.0A)
BAT  A 559 ( 3.8A)
ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
BAT  A 559 (-4.3A)
BAT  A 559 (-4.2A)
 0.64A 3hy7B-2rjqA:
35.7		 3hy7B-2rjqA:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		5 / 9 THR A 331
HIS A 334
GLU A 335
HIS A 338
HIS A 344
 BAT  A1000 ( 3.8A)
ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.38A 3hy7B-4dd8A:
25.8		 3hy7B-4dd8A:
30.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 5 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.17A 3kecA-1rm8A:
27.1		 3kecA-1rm8A:
48.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 5 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.18A 3kecA-2rjqA:
10.1		 3kecA-2rjqA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 5 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.38A 3kecA-4dd8A:
10.1		 3kecA-4dd8A:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		3 / 3 HIS A 246
GLU A 247
HIS A 250
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
 0.21A 3kecB-1rm8A:
26.8		 3kecB-1rm8A:
48.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		3 / 3 HIS A 410
GLU A 411
HIS A 414
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
 0.17A 3kecB-2rjqA:
10.0		 3kecB-2rjqA:
18.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 5 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.26A 3likA-1rm8A:
28.2		 3likA-1rm8A:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 5 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.15A 3likA-2rjqA:
10.5		 3likA-2rjqA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 5 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.40A 3likA-4dd8A:
10.4		 3likA-4dd8A:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.20A 3lilA-1rm8A:
28.3		 3lilA-1rm8A:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.17A 3lilA-2rjqA:
10.5		 3lilA-2rjqA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 4 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.41A 3lilA-4dd8A:
10.4		 3lilA-4dd8A:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 5 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.21A 3ljgA-1rm8A:
28.0		 3ljgA-1rm8A:
50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 5 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.18A 3ljgA-2rjqA:
10.7		 3ljgA-2rjqA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 5 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.41A 3ljgA-4dd8A:
10.5		 3ljgA-4dd8A:
18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 5 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.25A 3lkaA-1rm8A:
28.2		 3lkaA-1rm8A:
51.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 5 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.17A 3lkaA-2rjqA:
10.4		 3lkaA-2rjqA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 5 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.37A 3lkaA-4dd8A:
10.4		 3lkaA-4dd8A:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		5 / 6 HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.32A 4a7bA-1rm8A:
27.3		 4a7bA-1rm8A:
48.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 6 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.29A 4a7bA-2rjqA:
9.8		 4a7bA-2rjqA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 6 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.43A 4a7bA-4dd8A:
9.8		 4a7bA-4dd8A:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 5 HIS A 208
HIS A 246
GLU A 247
HIS A 250
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
 0.31A 4a7bB-1rm8A:
27.1		 4a7bB-1rm8A:
48.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 2rjq ADAMTS-5
(Homo
sapiens) 		3 / 3 ILE A 442
MET A 381
ASP A 377
 BAT  A 559 (-4.3A)
BAT  A 559 ( 3.7A)
BAT  A 559 (-3.7A)
 0.82A 5h2uA-2rjqA:
undetectable		 5h2uA-2rjqA:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 4 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.18A 5n5jA-1rm8A:
28.1		 5n5jA-1rm8A:
51.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 4 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.16A 5n5jA-2rjqA:
10.5		 5n5jA-2rjqA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 4 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.39A 5n5jA-4dd8A:
10.4		 5n5jA-4dd8A:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens) 		4 / 5 HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.16A 5n5kA-1rm8A:
27.8		 5n5kA-1rm8A:
50.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2rjq ADAMTS-5
(Homo
sapiens) 		4 / 5 HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.15A 5n5kA-2rjqA:
10.6		 5n5kA-2rjqA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens) 		4 / 5 HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.40A 5n5kA-4dd8A:
10.4		 5n5kA-4dd8A:
21.27