SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'BAM'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 4izx RICIN B-LIKE LECTIN
(Macrolepiota
procera) 		3 / 3 TRP A 128
ARG A  89
THR A 127
 None
BAM  A 202 (-3.9A)
None
 0.99A 1df7A-4izxA:
undetectable		 1df7A-4izxA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 GLY A  88
GLY A  89
GLY A  90
PHE A 209
HIS A 286
 BAM  A 407 ( 3.9A)
BAM  A 407 (-3.4A)
BAM  A 407 (-3.5A)
None
BAM  A 407 (-3.9A)
 0.60A 1dx6A-5jd4A:
17.7		 1dx6A-5jd4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 GLY A  88
GLY A  89
GLY A  90
PHE A 209
HIS A 286
 BAM  A 407 ( 3.9A)
BAM  A 407 (-3.4A)
BAM  A 407 (-3.5A)
None
BAM  A 407 (-3.9A)
 0.87A 1w6rA-5jd4A:
17.8		 1w6rA-5jd4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		6 / 9 GLY A  89
GLY A  90
ALA A 162
PHE A 218
PHE A 209
HIS A 286
 BAM  A 407 (-3.4A)
BAM  A 407 (-3.5A)
BAM  A 407 (-3.2A)
None
None
BAM  A 407 (-3.9A)
 1.02A 2aceA-5jd4A:
4.6		 2aceA-5jd4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 1.08A 2bm9A-5jd4A:
2.1		 2bm9A-5jd4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 1.08A 2bm9D-5jd4A:
2.5		 2bm9D-5jd4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 0.93A 2br4A-5jd4A:
3.1		 2br4A-5jd4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 0.99A 2br4D-5jd4A:
3.2		 2br4D-5jd4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 LEU A 210
GLY A  89
SER A  40
ALA A 162
ALA A 165
 BAM  A 407 (-4.3A)
BAM  A 407 (-3.4A)
None
BAM  A 407 (-3.2A)
None
 1.00A 2br4F-5jd4A:
3.3		 2br4F-5jd4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 8 TYR A 189
GLY A 163
ALA A 161
ALA A 162
 None
None
BAM  A 407 (-3.1A)
BAM  A 407 (-3.2A)
 0.59A 2ej3A-5jd4A:
undetectable		 2ej3A-5jd4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5jd4 LAE6
(uncultured
bacterium) 		4 / 6 VAL A  36
SER A  40
LEU A 214
HIS A 286
 None
None
None
BAM  A 407 (-3.9A)
 1.23A 2f8dA-5jd4A:
undetectable		 2f8dA-5jd4A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 7 GLY A  88
ALA A 161
ALA A 162
PHE A 218
HIS A 286
 BAM  A 407 ( 3.9A)
BAM  A 407 (-3.1A)
BAM  A 407 (-3.2A)
None
BAM  A 407 (-3.9A)
 1.17A 2ha4B-5jd4A:
17.8		 2ha4B-5jd4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 7 GLY A  88
GLY A  89
ALA A 161
ALA A 162
HIS A 286
 BAM  A 407 ( 3.9A)
BAM  A 407 (-3.4A)
BAM  A 407 (-3.1A)
BAM  A 407 (-3.2A)
BAM  A 407 (-3.9A)
 0.91A 2ha4B-5jd4A:
17.8		 2ha4B-5jd4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		6 / 7 GLY A  89
GLY A  90
ALA A 161
ALA A 162
PHE A 218
HIS A 286
 BAM  A 407 (-3.4A)
BAM  A 407 (-3.5A)
BAM  A 407 (-3.1A)
BAM  A 407 (-3.2A)
None
BAM  A 407 (-3.9A)
 1.09A 2ha4B-5jd4A:
17.8		 2ha4B-5jd4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL
(Rattus
norvegicus) 		3 / 3 PHE A 267
SER A 276
LEU A 168
 BAM  A 600 (-3.5A)
None
None
 0.74A 2w1bA-1xx4A:
undetectable		 2w1bA-1xx4A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4izx RICIN B-LIKE LECTIN
(Macrolepiota
procera) 		4 / 7 GLN A   3
ILE A  87
TRP A  53
TYR A  10
 BAM  A 202 (-2.9A)
BAM  A 202 (-4.2A)
BAM  A 202 ( 4.3A)
None
 1.36A 2xz5D-4izxA:
undetectable
2xz5E-4izxA:
undetectable		 2xz5D-4izxA:
19.91
2xz5E-4izxA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 ALA A 162
GLY A 163
TYR A  86
ALA A 122
PHE A 218
 BAM  A 407 (-3.2A)
None
None
None
None
 1.06A 3qxyA-5jd4A:
undetectable		 3qxyA-5jd4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 11 ALA A 162
GLY A 163
TYR A  86
ALA A 122
PHE A 218
 BAM  A 407 (-3.2A)
None
None
None
None
 1.07A 3qxyB-5jd4A:
undetectable
3qxyQ-5jd4A:
undetectable		 3qxyB-5jd4A:
22.58
3qxyQ-5jd4A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 11 ALA A 162
GLY A 163
TYR A  86
ALA A 122
PHE A 218
 BAM  A 407 (-3.2A)
None
None
None
None
 1.09A 3rc0A-5jd4A:
undetectable		 3rc0A-5jd4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 ALA A 162
GLY A 163
TYR A  86
ALA A 122
PHE A 218
 BAM  A 407 (-3.2A)
None
None
None
None
 1.08A 3rc0B-5jd4A:
undetectable		 3rc0B-5jd4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 HIS A 286
GLY A  90
GLY A  88
TYR A 189
ALA A 122
 BAM  A 407 (-3.9A)
BAM  A 407 (-3.5A)
BAM  A 407 ( 3.9A)
None
None
 1.07A 3vywB-5jd4A:
undetectable		 3vywB-5jd4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 HIS A 286
GLY A  90
GLY A  88
TYR A 189
ALA A 122
 BAM  A 407 (-3.9A)
BAM  A 407 (-3.5A)
BAM  A 407 ( 3.9A)
None
None
 1.02A 3vywD-5jd4A:
undetectable		 3vywD-5jd4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 5jd4 LAE6
(uncultured
bacterium) 		5 / 12 GLY A 164
ALA A 162
THR A  98
HIS A  99
GLY A  89
 None
BAM  A 407 (-3.2A)
None
None
BAM  A 407 (-3.4A)
 0.81A 4ls7A-5jd4A:
undetectable		 4ls7A-5jd4A:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IEY_A_CLMA401_0
(ESTERASE)		 5jd4 LAE6
(uncultured
bacterium) 		8 / 11 ILE A  93
HIS A  99
ASP A 160
ALA A 161
LEU A 210
HIS A 286
GLY A 287
SER A 290
 None
None
None
BAM  A 407 (-3.1A)
BAM  A 407 (-4.3A)
BAM  A 407 (-3.9A)
None
None
 0.49A 6ieyA-5jd4A:
39.6
6ieyB-5jd4A:
39.7		 6ieyA-5jd4A:
40.91
6ieyB-5jd4A:
40.91