SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'B44'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_B_TA1B502_1 (TUBULIN BETA CHAIN)	3gd7	FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371 (Escherichia coli; Homo sapiens)	5 / 10	ASP A1275 LEU A1258 PHE A1257 THR A1252 LEU A1215	None None None B44 A 1 (-3.6A) None	1.38A	3j6gB-3gd7A: 1.7	3j6gB-3gd7A: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_D_TA1D502_1 (TUBULIN BETA CHAIN)	3gd7	FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371 (Escherichia coli; Homo sapiens)	5 / 10	ASP A1275 LEU A1258 PHE A1257 THR A1252 LEU A1215	None None None B44 A 1 (-3.6A) None	1.38A	3j6gD-3gd7A: undetectable	3j6gD-3gd7A: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_F_TA1F502_1 (TUBULIN BETA CHAIN)	3gd7	FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371 (Escherichia coli; Homo sapiens)	5 / 10	ASP A1275 LEU A1258 PHE A1257 THR A1252 LEU A1215	None None None B44 A 1 (-3.6A) None	1.38A	3j6gF-3gd7A: undetectable	3j6gF-3gd7A: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_H_TA1H502_1 (TUBULIN BETA CHAIN)	3gd7	FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371 (Escherichia coli; Homo sapiens)	5 / 10	ASP A1275 LEU A1258 PHE A1257 THR A1252 LEU A1215	None None None B44 A 1 (-3.6A) None	1.38A	3j6gH-3gd7A: undetectable	3j6gH-3gd7A: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_J_TA1J502_1 (TUBULIN BETA CHAIN)	3gd7	FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371 (Escherichia coli; Homo sapiens)	5 / 10	ASP A1275 LEU A1258 PHE A1257 THR A1252 LEU A1215	None None None B44 A 1 (-3.6A) None	1.38A	3j6gJ-3gd7A: undetectable	3j6gJ-3gd7A: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_L_TA1L502_1 (TUBULIN BETA CHAIN)	3gd7	FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371 (Escherichia coli; Homo sapiens)	5 / 10	ASP A1275 LEU A1258 PHE A1257 THR A1252 LEU A1215	None None None B44 A 1 (-3.6A) None	1.38A	3j6gL-3gd7A: undetectable	3j6gL-3gd7A: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_N_TA1N502_1 (TUBULIN BETA CHAIN)	3gd7	FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371 (Escherichia coli; Homo sapiens)	5 / 10	ASP A1275 LEU A1258 PHE A1257 THR A1252 LEU A1215	None None None B44 A 1 (-3.6A) None	1.38A	3j6gN-3gd7A: undetectable	3j6gN-3gd7A: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_P_TA1P502_1 (TUBULIN BETA CHAIN)	3gd7	FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371 (Escherichia coli; Homo sapiens)	5 / 10	ASP A1275 LEU A1258 PHE A1257 THR A1252 LEU A1215	None None None B44 A 1 (-3.6A) None	1.38A	3j6gP-3gd7A: undetectable	3j6gP-3gd7A: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3J6G_R_TA1R502_1 (TUBULIN BETA CHAIN)	3gd7	FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371 (Escherichia coli; Homo sapiens)	5 / 10	ASP A1275 LEU A1258 PHE A1257 THR A1252 LEU A1215	None None None B44 A 1 (-3.6A) None	1.38A	3j6gR-3gd7A: undetectable	3j6gR-3gd7A: 22.53

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3J6G_B_TA1B502_1","TUBULIN BETA CHAIN","3gd7","FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE\/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371","Escherichia coli;Homo sapiens",5,"ASP A1275;LEU A1258;PHE A1257;THR A1252;LEU A1215","None;None;None;B44 A   1 (-3.6A);None","1.38A","3j6gB-3gd7A:1.7",null],["3J6G_D_TA1D502_1","TUBULIN BETA CHAIN","3gd7","FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE\/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371","Escherichia coli;Homo sapiens",5,"ASP A1275;LEU A1258;PHE A1257;THR A1252;LEU A1215","None;None;None;B44 A   1 (-3.6A);None","1.38A","3j6gD-3gd7A:undetectable","3j6gB-3gd7A:22.53"],["3J6G_F_TA1F502_1","TUBULIN BETA CHAIN","3gd7","FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE\/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371","Escherichia coli;Homo sapiens",5,"ASP A1275;LEU A1258;PHE A1257;THR A1252;LEU A1215","None;None;None;B44 A   1 (-3.6A);None","1.38A","3j6gF-3gd7A:undetectable","3j6gD-3gd7A:22.53"],["3J6G_H_TA1H502_1","TUBULIN BETA CHAIN","3gd7","FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE\/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371","Escherichia coli;Homo sapiens",5,"ASP A1275;LEU A1258;PHE A1257;THR A1252;LEU A1215","None;None;None;B44 A   1 (-3.6A);None","1.38A","3j6gH-3gd7A:undetectable","3j6gF-3gd7A:22.53"],["3J6G_J_TA1J502_1","TUBULIN BETA CHAIN","3gd7","FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE\/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371","Escherichia coli;Homo sapiens",5,"ASP A1275;LEU A1258;PHE A1257;THR A1252;LEU A1215","None;None;None;B44 A   1 (-3.6A);None","1.38A","3j6gJ-3gd7A:undetectable","3j6gH-3gd7A:22.53"],["3J6G_L_TA1L502_1","TUBULIN BETA CHAIN","3gd7","FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE\/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371","Escherichia coli;Homo sapiens",5,"ASP A1275;LEU A1258;PHE A1257;THR A1252;LEU A1215","None;None;None;B44 A   1 (-3.6A);None","1.38A","3j6gL-3gd7A:undetectable","3j6gJ-3gd7A:22.53"],["3J6G_N_TA1N502_1","TUBULIN BETA CHAIN","3gd7","FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE\/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371","Escherichia coli;Homo sapiens",5,"ASP A1275;LEU A1258;PHE A1257;THR A1252;LEU A1215","None;None;None;B44 A   1 (-3.6A);None","1.38A","3j6gN-3gd7A:undetectable","3j6gL-3gd7A:22.53"],["3J6G_P_TA1P502_1","TUBULIN BETA CHAIN","3gd7","FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE\/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371","Escherichia coli;Homo sapiens",5,"ASP A1275;LEU A1258;PHE A1257;THR A1252;LEU A1215","None;None;None;B44 A   1 (-3.6A);None","1.38A","3j6gP-3gd7A:undetectable","3j6gN-3gd7A:22.53"],["3J6G_R_TA1R502_1","TUBULIN BETA CHAIN","3gd7","FUSION COMPLEX OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, RESIDUES 1193-1427 AND MALTOSE\/MALTODEXTRIN IMPORT ATP-BINDING PROTEIN MALK, RESIDUES 219-371","Escherichia coli;Homo sapiens",5,"ASP A1275;LEU A1258;PHE A1257;THR A1252;LEU A1215","None;None;None;B44 A   1 (-3.6A);None","1.38A","3j6gR-3gd7A:undetectable","3j6gP-3gd7A:22.53"]]