SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AZ8'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.82A 1c6yB-5ufmA:
undetectable
1c6yB-5ufmA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 149
GLY A 136
TYR A  28
PHE A  36
PHE A 168
None
AZ8  A 302 ( 3.5A)
None
SAH  A 301 (-3.4A)
AZ8  A 302 (-4.8A)
1.24A 1fdsA-5ufmA:
6.2
1fdsA-5ufmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.75A 1hsgB-5ufmA:
undetectable
1hsgB-5ufmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.80A 1k6cB-5ufmA:
undetectable
1k6cB-5ufmA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.81A 1sdtB-5ufmA:
undetectable
1sdtB-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 11 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.81A 1sdvB-5ufmA:
undetectable
1sdvB-5ufmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.79A 2avoB-5ufmA:
undetectable
2avoB-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.79A 2bpxB-5ufmA:
undetectable
2bpxB-5ufmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.80A 2f80A-5ufmA:
undetectable
2f80A-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.79A 2f81A-5ufmA:
undetectable
2f81A-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.81A 2f81B-5ufmA:
undetectable
2f81B-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.83A 2f8gA-5ufmA:
undetectable
2f8gA-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.82A 2ienB-5ufmA:
undetectable
2ienB-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
4 / 4 ASP A  95
ASP A  72
ASP A  45
GLY A 136
SAH  A 301 (-2.7A)
None
None
AZ8  A 302 ( 3.5A)
1.39A 2igtC-5ufmA:
13.9
2igtC-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.81A 2pymA-5ufmA:
undetectable
2pymA-5ufmA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.87A 2q5kB-5ufmA:
undetectable
2q5kB-5ufmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.84A 3cywA-5ufmA:
undetectable
3cywA-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.81A 3cywB-5ufmA:
undetectable
3cywB-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 9 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.91A 3ektA-5ufmA:
undetectable
3ektA-5ufmA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 10 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.84A 3ekvA-5ufmA:
undetectable
3ekvA-5ufmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 11 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.84A 3ekxA-5ufmA:
undetectable
3ekxA-5ufmA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.83A 3lzuA-5ufmA:
undetectable
3lzuA-5ufmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.88A 3oxcA-5ufmA:
undetectable
3oxcA-5ufmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 10 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.84A 3oxwA-5ufmA:
undetectable
3oxwA-5ufmA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 9 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.90A 4dqcB-5ufmA:
undetectable
4dqcB-5ufmA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 10 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.85A 4ll3B-5ufmA:
undetectable
4ll3B-5ufmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 10 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.82A 4ll3A-5ufmA:
undetectable
4ll3A-5ufmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 11 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.86A 4njvB-5ufmA:
undetectable
4njvB-5ufmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
3 / 3 HIS A 139
SER A 166
ARG A 212
AZ8  A 302 (-4.5A)
None
AZ8  A 302 (-3.9A)
0.65A 5u63A-5ufmA:
2.4
5u63A-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 GLY A  74
GLY A  76
ASP A  95
VAL A 120
HIS A 140
SAH  A 301 (-3.6A)
SAH  A 301 (-3.6A)
SAH  A 301 (-2.7A)
SAH  A 301 (-4.1A)
AZ8  A 302 (-4.0A)
0.62A 5wy0A-5ufmA:
13.7
5wy0A-5ufmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.89A 6dj1B-5ufmA:
undetectable
6dj1B-5ufmA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)
5ufm METHYLTRANSFERASE
DOMAIN PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A  95
GLY A  76
ASP A  72
VAL A 120
GLY A 136
SAH  A 301 (-2.7A)
SAH  A 301 (-3.6A)
None
SAH  A 301 (-4.1A)
AZ8  A 302 ( 3.5A)
0.90A 6dj2B-5ufmA:
undetectable
6dj2B-5ufmA:
17.98