SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AZ1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 401
TYR A 269
ILE A 267
 AZ1  A 502 ( 4.1A)
None
None
 0.75A 3eteA-1tufA:
undetectable
3eteB-1tufA:
undetectable		 3eteA-1tufA:
22.86
3eteB-1tufA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1tuf DIAMINOPIMELATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 TYR A 401
GLY A 306
ILE A 302
GLY A 263
 AZ1  A 502 ( 4.1A)
LLP  A  83 ( 3.0A)
None
LLP  A  83 ( 3.9A)
 0.86A 5alcL-1tufA:
undetectable		 5alcL-1tufA:
16.55