SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AYZ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 5owc -
(-) 		6 / 7 GLY A  28
HIS A  46
ASP A  47
TYR A  50
PRO A  60
LYS A  61
 AYZ  A 202 ( 3.5A)
AYZ  A 202 (-4.0A)
CA  A 201 ( 2.2A)
AYZ  A 202 ( 4.9A)
None
None
 0.57A 1th6A-5owcA:
19.4		 1th6A-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5owc -
(-) 		6 / 7 GLY A  28
HIS A  46
ASP A  47
TYR A  50
PRO A  60
LYS A  61
 AYZ  A 202 ( 3.5A)
AYZ  A 202 (-4.0A)
CA  A 201 ( 2.2A)
AYZ  A 202 ( 4.9A)
None
None
 0.59A 2armA-5owcA:
19.4		 2armA-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5owc -
(-) 		3 / 3 ASP A  47
TYR A  50
LYS A  61
 CA  A 201 ( 2.2A)
AYZ  A 202 ( 4.9A)
None
 0.56A 2othA-5owcA:
19.4		 2othA-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5owc -
(-) 		4 / 8 LYS A   1
HIS A  46
ASP A  91
ALA A  53
 None
AYZ  A 202 (-4.0A)
None
None
 1.28A 2rk8A-5owcA:
2.0		 2rk8A-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5owc -
(-) 		4 / 5 HIS A  46
ASP A  47
TYR A  50
PRO A  60
 AYZ  A 202 (-4.0A)
CA  A 201 ( 2.2A)
AYZ  A 202 ( 4.9A)
None
 0.52A 3fo7A-5owcA:
19.3		 3fo7A-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5owc -
(-) 		4 / 5 HIS A  46
ASP A  47
TYR A  50
PRO A  60
 AYZ  A 202 (-4.0A)
CA  A 201 ( 2.2A)
AYZ  A 202 ( 4.9A)
None
 0.51A 3h1xA-5owcA:
19.4		 3h1xA-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 5owc -
(-) 		5 / 12 LEU A   5
GLY A  28
GLY A  30
TYR A  50
PRO A  60
 AYZ  A 202 (-4.6A)
AYZ  A 202 ( 3.5A)
AYZ  A 202 ( 3.6A)
AYZ  A 202 ( 4.9A)
None
 0.76A 6ce2B-5owcA:
18.9		 6ce2B-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 5owc -
(-) 		5 / 12 LEU A   5
GLY A  28
TYR A  50
PRO A  60
LYS A  61
 AYZ  A 202 (-4.6A)
AYZ  A 202 ( 3.5A)
AYZ  A 202 ( 4.9A)
None
None
 0.88A 6ce2B-5owcA:
18.9		 6ce2B-5owcA:
undetectable