SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AYE'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KQD_A_ADNA1002_1 (APRATAXIN AND PNK-LIKE FACTOR)	5w8u	ORF1AB PROTEIN (Middle East respiratory syndrome-related coronavirus)	4 / 4	TYR A 279 ASN A 114 CYH A 111 TYR A 112	None None AYE A 404 (-1.7A) None	1.41A	2kqdA-5w8uA: 0.0	2kqdA-5w8uA: 16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OAX_D_SNLD4001_2 (MINERALOCORTICOID RECEPTOR)	5ohk	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30 (Homo sapiens)	4 / 5	LEU A 165 LEU A 496 CYH A 77 THR A 76	None None AYE A 602 (-1.7A) None	1.41A	2oaxD-5ohkA: undetectable	2oaxD-5ohkA: 22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_B_SAMB602_1 (HYPOTHETICAL PROTEIN)	5ohk	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30 (Homo sapiens)	3 / 3	GLU A 159 ASP A 161 TYR A 495	AYE A 602 (-3.5A) None None	0.78A	2yvlB-5ohkA: undetectable	2yvlB-5ohkA: 24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_C_SAMC604_1 (HYPOTHETICAL PROTEIN)	5ohk	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30 (Homo sapiens)	4 / 4	GLY A 451 GLU A 159 ASP A 161 TYR A 495	AYE A 602 (-4.7A) AYE A 602 (-3.5A) None None	1.29A	2yvlC-5ohkA: undetectable	2yvlC-5ohkA: 24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MB5_A_SAMA301_1 (SAM-DEPENDENT METHYLTRANSFERASE)	5ohk	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30 (Homo sapiens)	4 / 4	GLY A 451 GLU A 159 ASP A 161 ASP A 447	AYE A 602 (-4.7A) AYE A 602 (-3.5A) None None	1.32A	3mb5A-5ohkA: undetectable	3mb5A-5ohkA: 22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACB_C_DXCC1475_0 (TRANSLATION ELONGATION FACTOR SELB)	6ei1	ZINC FINGER WITH UFM1-SPECIFIC PEPTIDASE DOMAIN PROTEIN (Homo sapiens)	4 / 8	ILE A 397 ILE A 424 SER A 352 GLY A 359	None None None AYE A 601 ( 4.7A)	0.83A	4acbC-6ei1A: undetectable	4acbC-6ei1A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EY7_A_E20A604_1 (ACETYLCHOLINESTERASE)	6ei1	ZINC FINGER WITH UFM1-SPECIFIC PEPTIDASE DOMAIN PROTEIN (Homo sapiens)	5 / 11	TRP A 423 GLY A 357 TYR A 362 HIS A 491 GLY A 490	AYE A 601 (-3.0A) AYE A 601 ( 4.0A) None AYE A 601 (-4.1A) AYE A 601 (-3.8A)	1.19A	4ey7A-6ei1A: undetectable	4ey7A-6ei1A: 7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EY7_B_E20B605_1 (ACETYLCHOLINESTERASE)	6ei1	ZINC FINGER WITH UFM1-SPECIFIC PEPTIDASE DOMAIN PROTEIN (Homo sapiens)	5 / 11	TRP A 423 GLY A 357 TYR A 362 HIS A 491 GLY A 490	AYE A 601 (-3.0A) AYE A 601 ( 4.0A) None AYE A 601 (-4.1A) AYE A 601 (-3.8A)	1.21A	4ey7B-6ei1A: undetectable	4ey7B-6ei1A: 7.28

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2KQD_A_ADNA1002_1","APRATAXIN AND PNK-LIKE FACTOR","5w8u","ORF1AB PROTEIN","Middle East respiratory syndrome-related coronavirus",4,"TYR A 279;ASN A 114;CYH A 111;TYR A 112","None;None;AYE A 404 (-1.7A);None","1.41A","2kqdA-5w8uA:0.0",null],["2OAX_D_SNLD4001_2","MINERALOCORTICOID RECEPTOR","5ohk","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30","Homo sapiens",4,"LEU A 165;LEU A 496;CYH A  77;THR A  76","None;None;AYE A 602 (-1.7A);None","1.41A","2oaxD-5ohkA:undetectable","2kqdA-5w8uA:16.06"],["2YVL_B_SAMB602_1","HYPOTHETICAL PROTEIN","5ohk","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30","Homo sapiens",3,"GLU A 159;ASP A 161;TYR A 495","AYE A 602 (-3.5A);None;None","0.78A","2yvlB-5ohkA:undetectable","2oaxD-5ohkA:22.29"],["2YVL_C_SAMC604_1","HYPOTHETICAL PROTEIN","5ohk","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30","Homo sapiens",4,"GLY A 451;GLU A 159;ASP A 161;TYR A 495","AYE A 602 (-4.7A);AYE A 602 (-3.5A);None;None","1.29A","2yvlC-5ohkA:undetectable","2yvlB-5ohkA:24.41"],["3MB5_A_SAMA301_1","SAM-DEPENDENT METHYLTRANSFERASE","5ohk","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30,UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30","Homo sapiens",4,"GLY A 451;GLU A 159;ASP A 161;ASP A 447","AYE A 602 (-4.7A);AYE A 602 (-3.5A);None;None","1.32A","3mb5A-5ohkA:undetectable","2yvlC-5ohkA:24.41"],["4ACB_C_DXCC1475_0","TRANSLATION ELONGATION FACTOR SELB","6ei1","ZINC FINGER WITH UFM1-SPECIFIC PEPTIDASE DOMAIN PROTEIN","Homo sapiens",4,"ILE A 397;ILE A 424;SER A 352;GLY A 359","None;None;None;AYE A 601 ( 4.7A)","0.83A","4acbC-6ei1A:undetectable","3mb5A-5ohkA:22.35"],["4EY7_A_E20A604_1","ACETYLCHOLINESTERASE","6ei1","ZINC FINGER WITH UFM1-SPECIFIC PEPTIDASE DOMAIN PROTEIN","Homo sapiens",5,"TRP A 423;GLY A 357;TYR A 362;HIS A 491;GLY A 490","AYE A 601 (-3.0A);AYE A 601 ( 4.0A);None;AYE A 601 (-4.1A);AYE A 601 (-3.8A)","1.19A","4ey7A-6ei1A:undetectable","4acbC-6ei1A:undetectable"],["4EY7_B_E20B605_1","ACETYLCHOLINESTERASE","6ei1","ZINC FINGER WITH UFM1-SPECIFIC PEPTIDASE DOMAIN PROTEIN","Homo sapiens",5,"TRP A 423;GLY A 357;TYR A 362;HIS A 491;GLY A 490","AYE A 601 (-3.0A);AYE A 601 ( 4.0A);None;AYE A 601 (-4.1A);AYE A 601 (-3.8A)","1.21A","4ey7B-6ei1A:undetectable","4ey7A-6ei1A:7.28"]]