SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AUN'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 ASN A 173
GLY A 196
CYH A 201
THR A 203
GLY A 285
 AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
AUN  A 401 ( 3.2A)
 0.58A 1jr1A-5ou3A:
48.5		 1jr1A-5ou3A:
43.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 ASP A 143
ASN A 173
GLY A 196
CYH A 201
THR A 203
 AUN  A 401 (-3.5A)
AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
 0.86A 1jr1A-5ou3A:
48.5		 1jr1A-5ou3A:
43.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 ASN A 173
GLY A 196
THR A 203
GLY A 285
 AUN  A 401 ( 3.1A)
None
None
AUN  A 401 ( 3.2A)
 0.46A 1jr1B-5ou3A:
48.4		 1jr1B-5ou3A:
43.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 ASN A 173
GLY A 196
CYH A 201
GLY A 285
 AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
AUN  A 401 ( 3.2A)
 0.34A 1me7A-5ou3A:
47.0		 1me7A-5ou3A:
10.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 8 ASN A 173
CYH A 201
THR A 203
MET A 284
GLY A 285
 AUN  A 401 ( 3.1A)
IMP  A 400 (-3.2A)
None
None
AUN  A 401 ( 3.2A)
 0.24A 4fo4A-5ou3A:
53.0		 4fo4A-5ou3A:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 8 ASP A 143
CYH A 201
THR A 203
MET A 284
GLY A 285
 AUN  A 401 (-3.5A)
IMP  A 400 (-3.2A)
None
None
AUN  A 401 ( 3.2A)
 0.77A 4fo4A-5ou3A:
53.0		 4fo4A-5ou3A:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		6 / 8 ASN A 173
GLY A 196
CYH A 201
THR A 203
MET A 284
GLY A 285
 AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
None
AUN  A 401 ( 3.2A)
 0.32A 4fo4B-5ou3A:
51.9		 4fo4B-5ou3A:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		6 / 9 ASP A 143
ASN A 173
GLY A 196
CYH A 201
THR A 203
ASP A 234
 AUN  A 401 (-3.5A)
AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
IMP  A 400 (-2.6A)
 0.42A 4fxsA-5ou3A:
52.5		 4fxsA-5ou3A:
48.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 LEU A 153
HIS A 146
ALA A 147
ALA A 188
 None
AUN  A 401 (-4.4A)
None
None
 0.82A 4g77A-5ou3A:
undetectable		 4g77A-5ou3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 283
GLY A 285
GLY A 268
ASN A  94
ARG A 282
 IMP  A 400 (-3.3A)
AUN  A 401 ( 3.2A)
None
None
None
 1.11A 6gngB-5ou3A:
undetectable		 6gngB-5ou3A:
9.98