SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AUC'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQT_B_ACTB1868_0 (FPRA)	4ovb	PROTEIN OSA (Shigella flexneri)	3 / 3	ALA A 106 HIS A 107 VAL A 110	None AUC A 203 (-3.7A) None	0.25A	1lqtB-4ovbA: undetectable	1lqtB-4ovbA: 16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQU_B_ACTB1425_0 (FPRA)	4ovb	PROTEIN OSA (Shigella flexneri)	3 / 3	ALA A 106 HIS A 107 VAL A 110	None AUC A 203 (-3.7A) None	0.25A	1lquB-4ovbA: undetectable	1lquB-4ovbA: 16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZN_A_SAMA401_0 (UNCHARACTERIZED PROTEIN MJ0883)	4ovb	PROTEIN OSA (Shigella flexneri)	5 / 12	TYR A 68 GLY A 170 ASN A 70 VAL A 132 PHE A 134	AUC A 206 (-3.2A) None None None None	1.24A	2zznA-4ovbA: undetectable	2zznA-4ovbA: 18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM4_V_DR7V100_2 (PROTEASE)	3odm	PHOSPHOENOLPYRUVATE CARBOXYLASE (Clostridium perfringens)	5 / 10	GLY A 38 GLY A 39 LEU A 40 VAL A 77 ILE A 71	None AUC A 624 ( 4.2A) AUC A 624 (-4.2A) None None	1.05A	3em4V-3odmA: undetectable	3em4V-3odmA: 10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BPL_B_PA1B605_1 (LIPID A EXPORT ATP-BINDING/PERMEASE PROTEIN MSBA)	3odm	PHOSPHOENOLPYRUVATE CARBOXYLASE (Clostridium perfringens)	3 / 3	ARG A 344 ARG A 93 ARG A 82	AUC A 607 (-3.3A) None MLI A 901 (-2.8A)	1.07A	6bplA-3odmA: 2.3 6bplB-3odmA: undetectable	6bplA-3odmA: 10.42 6bplB-3odmA: 10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BPL_B_PA1B605_1 (LIPID A EXPORT ATP-BINDING/PERMEASE PROTEIN MSBA)	3odm	PHOSPHOENOLPYRUVATE CARBOXYLASE (Clostridium perfringens)	3 / 3	ARG A 390 ARG A 93 ARG A 82	AUC A 607 ( 4.5A) None MLI A 901 (-2.8A)	1.03A	6bplA-3odmA: 2.3 6bplB-3odmA: undetectable	6bplA-3odmA: 10.42 6bplB-3odmA: 10.42

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1LQT_B_ACTB1868_0","FPRA","4ovb","PROTEIN OSA","Shigella flexneri",3,"ALA A 106;HIS A 107;VAL A 110","None;AUC A 203 (-3.7A);None","0.25A","1lqtB-4ovbA:undetectable",null],["1LQU_B_ACTB1425_0","FPRA","4ovb","PROTEIN OSA","Shigella flexneri",3,"ALA A 106;HIS A 107;VAL A 110","None;AUC A 203 (-3.7A);None","0.25A","1lquB-4ovbA:undetectable","1lqtB-4ovbA:16.26"],["2ZZN_A_SAMA401_0","UNCHARACTERIZED PROTEIN MJ0883","4ovb","PROTEIN OSA","Shigella flexneri",5,"TYR A  68;GLY A 170;ASN A  70;VAL A 132;PHE A 134","AUC A 206 (-3.2A);None;None;None;None","1.24A","2zznA-4ovbA:undetectable","1lquB-4ovbA:16.26"],["3EM4_V_DR7V100_2","PROTEASE","3odm","PHOSPHOENOLPYRUVATE CARBOXYLASE","Clostridium perfringens",5,"GLY A  38;GLY A  39;LEU A  40;VAL A  77;ILE A  71","None;AUC A 624 ( 4.2A);AUC A 624 (-4.2A);None;None","1.05A","3em4V-3odmA:undetectable","2zznA-4ovbA:18.58"],["6BPL_B_PA1B605_1","LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA;LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA","3odm","PHOSPHOENOLPYRUVATE CARBOXYLASE","Clostridium perfringens",3,"ARG A 344;ARG A  93;ARG A  82","AUC A 607 (-3.3A);None;MLI A 901 (-2.8A)","1.07A","6bplA-3odmA:2.3;6bplB-3odmA:undetectable","3em4V-3odmA:10.75"],["6BPL_B_PA1B605_1","LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA;LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA","3odm","PHOSPHOENOLPYRUVATE CARBOXYLASE","Clostridium perfringens",3,"ARG A 390;ARG A  93;ARG A  82","AUC A 607 ( 4.5A);None;MLI A 901 (-2.8A)","1.03A","6bplA-3odmA:2.3;6bplB-3odmA:undetectable","6bplA-3odmA:10.42;6bplB-3odmA:10.42"]]