SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ATM'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QCA_A_FUAA221_1 (TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE)	2jau	5'(3')-DEOXYRIBONUCL EOTIDASE (Homo sapiens)	4 / 7	SER A 78 PHE A 75 PHE A 49 LEU A 108	ATM A1230 (-3.6A) ATM A1230 (-4.9A) ATM A1230 (-4.3A) None	1.13A	1qcaA-2jauA: undetectable	1qcaA-2jauA: 20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3APV_B_TP0B190_1 (ALPHA-1-ACID GLYCOPROTEIN 2)	2tmk	THYMIDYLATE KINASE (Saccharomyces cerevisiae)	5 / 12	LEU A 53 GLU A 149 ARG A 41 SER A 98 TYR A 102	ATM A 217 ( 4.7A) ATM A 217 ( 4.9A) ATM A 217 (-4.0A) ATM A 217 ( 4.8A) ATM A 217 (-3.4A)	1.46A	3apvB-2tmkA: undetectable	3apvB-2tmkA: 24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QL6_A_NIMA614_1 (LACTOPEROXIDASE)	2tmk	THYMIDYLATE KINASE (Saccharomyces cerevisiae)	4 / 7	GLU A 149 ARG A 150 PHE A 69 PRO A 39	ATM A 217 ( 4.9A) None ATM A 217 (-3.5A) ATM A 217 ( 4.2A)	1.40A	3ql6A-2tmkA: undetectable	3ql6A-2tmkA: 16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5GLM_A_ACTA613_0 (GLYCOSIDE HYDROLASE FAMILY 43)	2tmk	THYMIDYLATE KINASE (Saccharomyces cerevisiae)	3 / 3	ASP A 14 SER A 98 TYR A 102	ATM A 217 ( 3.0A) ATM A 217 ( 4.8A) ATM A 217 (-3.4A)	0.74A	5glmA-2tmkA: undetectable	5glmA-2tmkA: 20.52

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1QCA_A_FUAA221_1","TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE","2jau","5'(3')-DEOXYRIBONUCLEOTIDASE","Homo sapiens",4,"SER A  78;PHE A  75;PHE A  49;LEU A 108","ATM A1230 (-3.6A);ATM A1230 (-4.9A);ATM A1230 (-4.3A);None","1.13A","1qcaA-2jauA:undetectable",null],["3APV_B_TP0B190_1","ALPHA-1-ACID GLYCOPROTEIN 2","2tmk","THYMIDYLATE KINASE","Saccharomyces cerevisiae",5,"LEU A  53;GLU A 149;ARG A  41;SER A  98;TYR A 102","ATM A 217 ( 4.7A);ATM A 217 ( 4.9A);ATM A 217 (-4.0A);ATM A 217 ( 4.8A);ATM A 217 (-3.4A)","1.46A","3apvB-2tmkA:undetectable","1qcaA-2jauA:20.98"],["3QL6_A_NIMA614_1","LACTOPEROXIDASE","2tmk","THYMIDYLATE KINASE","Saccharomyces cerevisiae",4,"GLU A 149;ARG A 150;PHE A  69;PRO A  39","ATM A 217 ( 4.9A);None;ATM A 217 (-3.5A);ATM A 217 ( 4.2A)","1.40A","3ql6A-2tmkA:undetectable","3apvB-2tmkA:24.67"],["5GLM_A_ACTA613_0","GLYCOSIDE HYDROLASE FAMILY 43","2tmk","THYMIDYLATE KINASE","Saccharomyces cerevisiae",3,"ASP A  14;SER A  98;TYR A 102","ATM A 217 ( 3.0A);ATM A 217 ( 4.8A);ATM A 217 (-3.4A)","0.74A","5glmA-2tmkA:undetectable","3ql6A-2tmkA:16.78"]]