SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ASO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 6 SER A 170
ILE A 202
ALA A 125
ALA A 119
 None
None
ASO  A 305 (-4.6A)
None
 0.80A 1w0gA-4gn8A:
undetectable		 1w0gA-4gn8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 7 ARG A 101
LEU A 171
ASN A 154
TYR A 167
 ASO  A 305 (-3.0A)
None
CA  A 301 ( 2.4A)
None
 1.28A 4f8yC-4gn8A:
undetectable
4f8yD-4gn8A:
undetectable		 4f8yC-4gn8A:
19.40
4f8yD-4gn8A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 5 PRO A 229
ASP A 228
ILE A 208
VAL A 289
 ASO  A 304 (-4.4A)
None
None
None
 1.40A 4hytA-4gn8A:
undetectable		 4hytA-4gn8A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 8 ASN A 103
MET A 118
GLU A 121
GLU A 120
 ASO  A 305 ( 3.0A)
ASO  A 305 ( 4.4A)
ASO  A 305 (-2.4A)
None
 1.07A 4mj8A-4gn8A:
undetectable
4mj8C-4gn8A:
undetectable		 4mj8A-4gn8A:
20.60
4mj8C-4gn8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 8 ASN A 103
MET A 118
GLU A 121
GLU A 120
 ASO  A 305 ( 3.0A)
ASO  A 305 ( 4.4A)
ASO  A 305 (-2.4A)
None
 1.14A 4mj8B-4gn8A:
undetectable
4mj8C-4gn8A:
undetectable		 4mj8B-4gn8A:
20.60
4mj8C-4gn8A:
20.60