SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ASL'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		5 / 12 ALA A 185
LEU A 182
THR A  15
ILE A 195
LEU A 219
 None
None
ASL  A  11 ( 3.6A)
None
None
 1.10A 1qzfA-2no5A:
undetectable		 1qzfA-2no5A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		5 / 12 ALA A 185
LEU A 182
THR A  15
ILE A 195
LEU A 219
 None
None
ASL  A  11 ( 3.6A)
None
None
 1.11A 1qzfB-2no5A:
undetectable		 1qzfB-2no5A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		5 / 12 ALA A 185
LEU A 182
THR A  15
ILE A 195
LEU A 219
 None
None
ASL  A  11 ( 3.6A)
None
None
 1.11A 1qzfC-2no5A:
undetectable		 1qzfC-2no5A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		5 / 12 ALA A 185
LEU A 182
THR A  15
ILE A 195
LEU A 219
 None
None
ASL  A  11 ( 3.6A)
None
None
 1.11A 1qzfD-2no5A:
undetectable		 1qzfD-2no5A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		5 / 12 ALA A 185
LEU A 182
THR A  15
ILE A 195
LEU A 219
 None
None
ASL  A  11 ( 3.6A)
None
None
 1.11A 1qzfE-2no5A:
undetectable		 1qzfE-2no5A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		5 / 12 ALA A 185
LEU A 182
THR A  15
ILE A 195
LEU A 219
 None
None
ASL  A  11 ( 3.6A)
None
None
 1.17A 2oipD-2no5A:
undetectable		 2oipD-2no5A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		4 / 8 LEU A 219
ARG A 194
LEU A 182
GLY A  14
 None
None
None
ASL  A  11 ( 4.2A)
 0.88A 2po5A-2no5A:
2.8		 2po5A-2no5A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		4 / 8 MET A 125
SER A 133
VAL A  19
GLY A  14
 None
None
None
ASL  A  11 ( 4.2A)
 1.07A 2qd3A-2no5A:
2.3		 2qd3A-2no5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		4 / 8 SER A 176
LEU A 143
ALA A 116
LEU A 118
 ASL  A  11 ( 4.0A)
None
None
None
 0.82A 4ikjA-2no5A:
undetectable
4ikjB-2no5A:
undetectable		 4ikjA-2no5A:
18.33
4ikjB-2no5A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		4 / 8 LEU A 143
ALA A 116
LEU A 118
SER A 176
 None
None
None
ASL  A  11 ( 4.0A)
 0.93A 4ikkA-2no5A:
undetectable
4ikkB-2no5A:
undetectable		 4ikkA-2no5A:
18.33
4ikkB-2no5A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		4 / 8 LEU A 216
LEU A 219
LEU A 223
LYS A  12
 SO4  A1006 ( 3.4A)
None
None
ASL  A  11 ( 3.3A)
 0.82A 4klaA-2no5A:
2.8		 4klaA-2no5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		5 / 10 CYH A 142
LEU A 126
ALA A  12
LEU A 105
LEU A  17
 None
None
ASL  A  11 ( 3.3A)
None
None
 1.23A 4p65A-2no5A:
undetectable
4p65B-2no5A:
undetectable
4p65F-2no5A:
undetectable
4p65H-2no5A:
undetectable		 4p65A-2no5A:
20.34
4p65B-2no5A:
8.56
4p65F-2no5A:
8.56
4p65H-2no5A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		5 / 8 LEU A 126
ALA A  12
LEU A 130
LEU A 139
ALA A 116
 None
ASL  A  11 ( 3.3A)
None
None
None
 1.12A 4z90A-2no5A:
1.3
4z90B-2no5A:
undetectable
4z90C-2no5A:
undetectable
4z90D-2no5A:
undetectable
4z90E-2no5A:
undetectable		 4z90A-2no5A:
19.57
4z90B-2no5A:
19.57
4z90C-2no5A:
19.57
4z90D-2no5A:
19.57
4z90E-2no5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		5 / 7 LEU A 130
LEU A 139
ALA A 116
LEU A 126
ALA A  12
 None
None
None
None
ASL  A  11 ( 3.3A)
 1.09A 4z90F-2no5A:
undetectable
4z90G-2no5A:
undetectable
4z90H-2no5A:
undetectable
4z90J-2no5A:
undetectable		 4z90F-2no5A:
19.57
4z90G-2no5A:
19.57
4z90H-2no5A:
19.57
4z90J-2no5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 2no5 (S)-2-HALOACID
DEHALOGENASE IVA
(Burkholderia
cepacia) 		4 / 7 LEU A 105
THR A  15
ASP A 181
LEU A 139
 None
ASL  A  11 ( 3.6A)
ASL  A  11 ( 4.5A)
None
 1.05A 5jq7B-2no5A:
undetectable		 5jq7B-2no5A:
21.43