SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ASE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A 147
LEU A 160
ILE A 146
TYR A 131
GLN A 306
 SAM  A1349 (-4.7A)
SAM  A1349 (-4.1A)
None
None
ASE  A1350 (-3.4A)
 1.23A 2weyA-4a6eA:
undetectable		 2weyA-4a6eA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 PHE A 156
GLY A 188
GLY A 189
ASP A 256
TRP A 257
 ASE  A1350 ( 4.9A)
SAM  A1349 ( 4.0A)
SAM  A1349 ( 3.8A)
ASE  A1350 ( 2.9A)
None
 0.54A 3i5uA-4a6eA:
30.8		 3i5uA-4a6eA:
27.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		8 / 12 PHE A 143
LEU A 160
TRP A 164
GLY A 188
ILE A 211
PHE A 237
ARG A 252
ASP A 256
 SAM  A1349 (-3.8A)
SAM  A1349 (-4.1A)
SAM  A1349 (-4.2A)
SAM  A1349 ( 4.0A)
SAM  A1349 (-4.6A)
SAM  A1349 (-3.5A)
SAM  A1349 ( 3.8A)
ASE  A1350 ( 2.9A)
 1.03A 4a6dA-4a6eA:
52.4		 4a6dA-4a6eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		12 / 12 PHE A 143
TYR A 147
LEU A 160
TRP A 164
GLY A 187
GLY A 189
ILE A 211
VAL A 214
PHE A 237
ALA A 251
ARG A 252
ASP A 256
 SAM  A1349 (-3.8A)
SAM  A1349 (-4.7A)
SAM  A1349 (-4.1A)
SAM  A1349 (-4.2A)
SAM  A1349 (-3.6A)
SAM  A1349 ( 3.8A)
SAM  A1349 (-4.6A)
SAM  A1349 (-4.9A)
SAM  A1349 (-3.5A)
SAM  A1349 (-3.7A)
SAM  A1349 ( 3.8A)
ASE  A1350 ( 2.9A)
 0.29A 4a6dA-4a6eA:
52.4		 4a6dA-4a6eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		12 / 12 PHE A 143
LEU A 160
TRP A 164
GLY A 187
GLY A 189
ILE A 211
VAL A 214
PHE A 237
ALA A 251
ARG A 252
ASP A 256
TRP A 257
 SAM  A1349 (-3.8A)
SAM  A1349 (-4.1A)
SAM  A1349 (-4.2A)
SAM  A1349 (-3.6A)
SAM  A1349 ( 3.8A)
SAM  A1349 (-4.6A)
SAM  A1349 (-4.9A)
SAM  A1349 (-3.5A)
SAM  A1349 (-3.7A)
SAM  A1349 ( 3.8A)
ASE  A1350 ( 2.9A)
None
 0.02A 4a6eA-4a6eA:
55.0		 4a6eA-4a6eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		9 / 12 PHE A 143
LEU A 160
TRP A 164
GLY A 188
ILE A 211
PHE A 237
ARG A 252
ASP A 256
TRP A 257
 SAM  A1349 (-3.8A)
SAM  A1349 (-4.1A)
SAM  A1349 (-4.2A)
SAM  A1349 ( 4.0A)
SAM  A1349 (-4.6A)
SAM  A1349 (-3.5A)
SAM  A1349 ( 3.8A)
ASE  A1350 ( 2.9A)
None
 0.94A 4a6eA-4a6eA:
55.0		 4a6eA-4a6eA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 ASP A 185
GLY A 187
ASP A 210
ASP A 236
ASP A 256
TRP A 257
 SAM  A1349 ( 4.6A)
SAM  A1349 (-3.6A)
SAM  A1349 (-2.9A)
SAM  A1349 (-3.5A)
ASE  A1350 ( 2.9A)
None
 0.55A 4pghB-4a6eA:
25.6		 4pghB-4a6eA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 THR A 134
TYR A 131
TYR A 108
PHE A 143
 None
None
ASE  A1350 (-4.9A)
SAM  A1349 (-3.8A)
 1.33A 5lrbA-4a6eA:
undetectable		 5lrbA-4a6eA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		7 / 12 PHE A 143
GLY A 188
VAL A 214
PHE A 237
ARG A 252
ASP A 256
TRP A 257
 SAM  A1349 (-3.8A)
SAM  A1349 ( 4.0A)
SAM  A1349 (-4.9A)
SAM  A1349 (-3.5A)
SAM  A1349 ( 3.8A)
ASE  A1350 ( 2.9A)
None
 0.57A 5w7pA-4a6eA:
29.1		 5w7pA-4a6eA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 PHE A 143
GLY A 189
PHE A 237
ARG A 252
ASP A 256
TRP A 257
 SAM  A1349 (-3.8A)
SAM  A1349 ( 3.8A)
SAM  A1349 (-3.5A)
SAM  A1349 ( 3.8A)
ASE  A1350 ( 2.9A)
None
 1.13A 5w7pA-4a6eA:
29.1		 5w7pA-4a6eA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		4 / 8 SER A 113
MET A 109
MET A 105
TYR A 108
 ASE  A1350 ( 4.5A)
ASE  A1350 ( 4.8A)
ASE  A1350 (-4.4A)
ASE  A1350 (-4.9A)
 0.91A 5wqpA-4a6eA:
6.7		 5wqpA-4a6eA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 187
GLY A 189
PHE A 237
ASP A 256
TRP A 257
 SAM  A1349 (-3.6A)
SAM  A1349 ( 3.8A)
SAM  A1349 (-3.5A)
ASE  A1350 ( 2.9A)
None
 0.64A 6clxA-4a6eA:
32.5		 6clxA-4a6eA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens) 		6 / 11 GLY A 187
GLY A 189
ASP A 210
VAL A 214
ASP A 236
ASP A 256
 SAM  A1349 (-3.6A)
SAM  A1349 ( 3.8A)
SAM  A1349 (-2.9A)
SAM  A1349 (-4.9A)
SAM  A1349 (-3.5A)
ASE  A1350 ( 2.9A)
 0.57A 6i5zD-4a6eA:
25.5		 6i5zD-4a6eA:
27.99