SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ASD'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		3 / 3 ALA A 306
THR A 310
CYH A 437
 HEM  A 601 ( 3.6A)
ASD  A 602 (-3.9A)
HEM  A 601 (-2.3A)
 0.69A 3e4eB-4kq8A:
37.0		 3e4eB-4kq8A:
28.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		10 / 10 ARG A 115
ILE A 133
PHE A 134
TRP A 224
ILE A 305
ASP A 309
THR A 310
VAL A 370
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
None
ASD  A 602 ( 4.7A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.23A 3eqmA-4kq8A:
64.6		 3eqmA-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		12 / 12 ARG A 115
ILE A 133
PHE A 134
TRP A 224
ILE A 305
ALA A 306
ASP A 309
THR A 310
VAL A 370
LEU A 372
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
None
ASD  A 602 ( 4.7A)
HEM  A 601 ( 3.6A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
None
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.20A 3s79A-4kq8A:
64.5		 3s79A-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		5 / 12 ILE A 305
ALA A 306
ASP A 309
THR A 310
VAL A 369
 ASD  A 602 ( 4.7A)
HEM  A 601 ( 3.6A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
None
 1.27A 3s79A-4kq8A:
64.5		 3s79A-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3S7S_A_EXMA601_1
(CYTOCHROME P450 19A1)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		9 / 9 ARG A 115
ILE A 133
TRP A 224
ALA A 306
ASP A 309
THR A 310
VAL A 370
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
HEM  A 601 ( 3.6A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.24A 3s7sA-4kq8A:
64.3		 3s7sA-4kq8A:
92.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		4 / 6 MET A 160
MET A 446
ILE A 132
ILE A 133
 None
None
HEM  A 601 (-3.8A)
ASD  A 602 (-4.0A)
 0.91A 4olmA-4kq8A:
1.7		 4olmA-4kq8A:
19.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JKV_A_ASDA602_1
(AROMATASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		12 / 12 ARG A 115
ILE A 133
PHE A 134
TRP A 224
ILE A 305
ALA A 306
ASP A 309
THR A 310
VAL A 370
LEU A 372
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
None
ASD  A 602 ( 4.7A)
HEM  A 601 ( 3.6A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
None
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.24A 5jkvA-4kq8A:
64.4		 5jkvA-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JKW_A_TESA601_1
(AROMATASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		11 / 11 ARG A 115
ILE A 133
PHE A 134
TRP A 224
ILE A 305
ASP A 309
THR A 310
VAL A 370
VAL A 373
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
None
ASD  A 602 ( 4.7A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.0A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.22A 5jkwA-4kq8A:
64.4		 5jkwA-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JL6_A_ASDA601_1
(AROMATASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		9 / 9 ARG A 115
ILE A 133
TRP A 224
ILE A 305
ASP A 309
THR A 310
VAL A 370
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
ASD  A 602 ( 4.7A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.25A 5jl6A-4kq8A:
64.5		 5jl6A-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JL7_A_ASDA601_1
(AROMATASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		10 / 10 ARG A 115
ILE A 133
PHE A 134
TRP A 224
ILE A 305
ASP A 309
THR A 310
VAL A 370
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
None
ASD  A 602 ( 4.7A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.23A 5jl7A-4kq8A:
64.5		 5jl7A-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JL9_A_ASDA601_1
(AROMATASE)		 4kq8 CYTOCHROME P450 19A1
(Homo
sapiens) 		9 / 9 ARG A 115
ILE A 133
TRP A 224
ILE A 305
ASP A 309
THR A 310
VAL A 370
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
ASD  A 602 ( 4.7A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.22A 5jl9A-4kq8A:
64.4		 5jl9A-4kq8A:
92.05