SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ASC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 SER A  35
GLY A 180
TYR A 178
VAL A 116
PHE A 182
GLU A 118
 None
None
None
ASC  A 303 (-4.2A)
None
None
 1.34A 1a27A-4twlA:
undetectable		 1a27A-4twlA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CIL_A_ETSA263_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 1cilA-4twlA:
28.5		 1cilA-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DMY_B_AZMB900_1
(MURINE CARBONIC
ANHYDRASE V)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.40A 1dmyB-4twlA:
25.3		 1dmyB-4twlA:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		4 / 8 ASP A 314
HIS A 194
HIS A 135
ILE A 358
 ASC  A 501 (-2.7A)
ASC  A 501 (-4.1A)
ASC  A 501 (-4.1A)
ASC  A 501 ( 4.9A)
 0.91A 1ei6C-4rp8A:
undetectable		 1ei6C-4rp8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5zov -
(-) 		4 / 8 ASP A 314
HIS A 194
HIS A 135
ILE A 358
 ASC  A 501 (-2.7A)
ASC  A 501 (-4.0A)
ASC  A 501 (-4.0A)
ASC  A 501 ( 4.9A)
 0.98A 1ei6C-5zovA:
undetectable		 1ei6C-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		4 / 5 HIS A  95
ALA A 222
SER A 100
HIS A 102
 ASC  A 303 (-2.7A)
None
None
None
 1.24A 1errA-4twlA:
undetectable
1errB-4twlA:
undetectable		 1errA-4twlA:
21.03
1errB-4twlA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		4 / 7 PHE A 276
SER A  59
PHE A 361
ALA A 279
 None
ASC  A 501 ( 4.9A)
None
None
 1.13A 1fxvA-4rp8A:
0.9
1fxvB-4rp8A:
1.2		 1fxvA-4rp8A:
18.67
1fxvB-4rp8A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 3vxi DYP
(Bjerkandera
adusta) 		4 / 8 PRO A 187
GLY A 188
LEU A 281
ARG A 315
 None
ASC  A 502 (-4.6A)
None
HEM  A 501 ( 3.9A)
 0.84A 1h4oG-3vxiA:
undetectable		 1h4oG-3vxiA:
18.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JD0_B_AZMB2401_1
(CARBONIC ANHYDRASE
XII)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 1jd0B-4twlA:
27.4		 1jd0B-4twlA:
30.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.31A 1oq5A-4twlA:
28.8		 1oq5A-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YDB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
VAL A 116
VAL A 126
PHE A 182
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
None
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 1ydbA-4twlA:
28.5		 1ydbA-4twlA:
30.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 GLN A 114
PHE A  96
ASP A  70
HIS A  97
SER A  35
 ASC  A 303 (-4.1A)
None
ASC  A 303 (-3.5A)
ASC  A 303 (-4.4A)
None
 1.35A 1ynnC-4twlA:
undetectable		 1ynnC-4twlA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  69
HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 None
ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.65A 1z9yA-4twlA:
28.6		 1z9yA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  69
HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 None
ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.59A 1zgfA-4twlA:
28.7		 1zgfA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZSB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 1zsbA-4twlA:
28.6		 1zsbA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 2aw1A-4twlA:
28.6		 2aw1A-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		5 / 10 ALA A 316
ILE A 318
GLY A 193
HIS A 135
PHE A  52
 ASC  A 501 ( 3.7A)
None
None
ASC  A 501 (-4.1A)
None
 1.25A 2b17A-4rp8A:
undetectable		 2b17A-4rp8A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 8 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.30A 2gehA-4twlA:
28.6		 2gehA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5zov -
(-) 		5 / 11 SER A 295
THR A 133
GLY A 134
HIS A 135
GLN A 139
 None
None
None
ASC  A 501 (-4.0A)
ASC  A 501 (-3.1A)
 1.45A 2hmaA-5zovA:
undetectable		 2hmaA-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  69
HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 None
ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.48A 2pouA-4twlA:
28.7		 2pouA-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 5jt4 CYTOCHROME C'
(Achromobacter
xylosoxidans) 		5 / 5 ALA A  20
GLY A 113
CYH A 116
LYS A 117
HIS A 120
 ASC  A 202 ( 3.3A)
ASC  A 202 (-3.9A)
HEC  A 201 (-1.9A)
None
HEC  A 201 (-3.2A)
 0.35A 2yldA-5jt4A:
24.9		 2yldA-5jt4A:
99.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 5jt4 CYTOCHROME C'
(Achromobacter
xylosoxidans) 		5 / 5 ALA A  20
GLY A 113
CYH A 116
LYS A 117
HIS A 120
 ASC  A 202 ( 3.3A)
ASC  A 202 (-3.9A)
HEC  A 201 (-1.9A)
None
HEC  A 201 (-3.2A)
 0.29A 2ylgA-5jt4A:
25.1		 2ylgA-5jt4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  69
HIS A  97
VAL A 126
THR A 183
TRP A 193
 None
ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.57A 3bl1A-4twlA:
28.5		 3bl1A-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.28A 3cajA-4twlA:
28.6		 3cajA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 3czvA-4twlA:
28.4
3czvB-4twlA:
28.4		 3czvA-4twlA:
28.52
3czvB-4twlA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_B_AZMB263_1
(CARBONIC ANHYDRASE
13)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 3czvB-4twlA:
28.4		 3czvB-4twlA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DC3_A_AZMA263_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 3dc3A-4twlA:
28.6		 3dc3A-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCW_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.32A 3dcwA-4twlA:
28.7		 3dcwA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD0_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.32A 3dd0A-4twlA:
28.5		 3dd0A-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F4X_A_KLTA300_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.31A 3f4xA-4twlA:
28.4		 3f4xA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_A_PXLA313_1
(PYRIDOXAL KINASE)		 3vxi DYP
(Bjerkandera
adusta) 		4 / 4 SER A 361
HIS A 326
THR A 324
VAL A 192
 None
ASC  A 502 (-4.3A)
None
None
 1.29A 3fhxA-3vxiA:
undetectable		 3fhxA-3vxiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 3fw3A-4twlA:
27.0		 3fw3A-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 3fw3B-4twlA:
26.8		 3fw3B-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA701_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 3hs4A-4twlA:
28.9		 3hs4A-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_A_AZMA263_1
(CARBONIC ANHYDRASE 9)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 3iaiA-4twlA:
27.7		 3iaiA-4twlA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_B_AZMB263_1
(CARBONIC ANHYDRASE 9)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 3iaiB-4twlA:
27.8		 3iaiB-4twlA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_C_AZMC263_1
(CARBONIC ANHYDRASE 9)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 3iaiC-4twlA:
27.8		 3iaiC-4twlA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_D_AZMD263_1
(CARBONIC ANHYDRASE 9)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 3iaiD-4twlA:
27.7		 3iaiD-4twlA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		5 / 12 LEU A  23
GLY A 193
ASP A 314
GLY A 171
GLY A 134
 None
None
ASC  A 501 (-2.7A)
None
None
 1.16A 3ku1G-4rp8A:
undetectable		 3ku1G-4rp8A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.34A 3kwaA-4twlA:
28.3		 3kwaA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  69
HIS A  97
VAL A 126
THR A 183
TRP A 193
 None
ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.43A 3lxeA-4twlA:
28.1		 3lxeA-4twlA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  69
HIS A  97
VAL A 126
THR A 183
TRP A 193
 None
ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.44A 3lxeB-4twlA:
28.2		 3lxeB-4twlA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.31A 3mdzA-4twlA:
27.7		 3mdzA-4twlA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 126
THR A 183
PRO A 186
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
 0.92A 3mdzA-4twlA:
27.7		 3mdzA-4twlA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 3ml5A-4twlA:
28.2		 3ml5A-4twlA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		5 / 10 ILE A 313
ALA A  19
PHE A 290
SER A  59
ILE A 283
 None
None
None
ASC  A 501 ( 4.9A)
None
 1.25A 3qg2A-4rp8A:
undetectable		 3qg2A-4rp8A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		5 / 11 ASP A 314
PHE A  52
LEU A  23
ALA A 317
CYH A 315
 ASC  A 501 (-2.7A)
None
None
None
ASC  A 501 ( 4.5A)
 1.43A 3r2jB-4rp8A:
undetectable		 3r2jB-4rp8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		5 / 12 PHE A  52
LEU A  23
HIS A 135
ALA A 317
CYH A 315
 None
None
ASC  A 501 (-4.1A)
None
ASC  A 501 ( 4.5A)
 1.33A 3r2jC-4rp8A:
undetectable		 3r2jC-4rp8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		5 / 11 ASP A 314
PHE A  52
LEU A  23
ALA A 317
CYH A 315
 ASC  A 501 (-2.7A)
None
None
None
ASC  A 501 ( 4.5A)
 1.48A 3r2jD-4rp8A:
undetectable		 3r2jD-4rp8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		4 / 6 LEU A  62
ALA A 316
ASP A 314
LEU A  55
 None
ASC  A 501 ( 3.7A)
ASC  A 501 (-2.7A)
None
 1.10A 3rozA-4rp8A:
undetectable		 3rozA-4rp8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 3v2jA-4twlA:
28.6		 3v2jA-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VXI_A_ASCA502_0
(DYP)		 3vxi DYP
(Bjerkandera
adusta) 		5 / 5 ALA A 190
ASN A 313
ARG A 315
PRO A 321
HIS A 326
 ASC  A 502 (-3.4A)
ASC  A 502 ( 3.0A)
HEM  A 501 ( 3.9A)
ASC  A 502 (-3.6A)
ASC  A 502 (-4.3A)
 0.01A 3vxiA-3vxiA:
73.0		 3vxiA-3vxiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 5jt4 CYTOCHROME C'
(Achromobacter
xylosoxidans) 		5 / 5 ALA A  20
GLY A 113
CYH A 116
LYS A 117
HIS A 120
 ASC  A 202 ( 3.3A)
ASC  A 202 (-3.9A)
HEC  A 201 (-1.9A)
None
HEC  A 201 (-3.2A)
 0.36A 3zwiA-5jt4A:
24.9		 3zwiA-5jt4A:
99.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CIP_A_ASCA130_0
(CYTOCHROME C')		 5jt4 CYTOCHROME C'
(Achromobacter
xylosoxidans) 		4 / 4 ALA A  20
GLY A 113
CYH A 116
HIS A 120
 ASC  A 202 ( 3.3A)
ASC  A 202 (-3.9A)
HEC  A 201 (-1.9A)
HEC  A 201 (-3.2A)
 0.10A 4cipA-5jt4A:
25.0		 4cipA-5jt4A:
99.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COQ_A_SANA300_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 4coqA-4twlA:
31.5		 4coqA-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COQ_B_SANB300_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 9 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 4coqB-4twlA:
31.3		 4coqB-4twlA:
31.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5zov -
(-) 		4 / 8 GLY A 356
ILE A 358
ILE A 280
THR A  88
 None
ASC  A 501 ( 4.9A)
None
None
 0.48A 4em2A-5zovA:
undetectable		 4em2A-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0C_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.30A 4g0cA-4twlA:
28.5		 4g0cA-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_A_AZMA302_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 4g7aA-4twlA:
30.8		 4g7aA-4twlA:
34.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_B_AZMB302_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 4g7aB-4twlA:
30.8		 4g7aB-4twlA:
34.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 5zov -
(-) 		4 / 4 TYR A  87
THR A 285
VAL A  55
ILE A 280
 ASC  A 501 (-4.0A)
None
None
None
 1.08A 4jx1F-5zovA:
undetectable		 4jx1F-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 4k0sA-4twlA:
28.8		 4k0sA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.31A 4k0zA-4twlA:
28.9		 4k0zA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 4k13A-4twlA:
28.9		 4k13A-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 4lu3A-4twlA:
27.8		 4lu3A-4twlA:
30.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.31A 4m2rA-4twlA:
28.6		 4m2rA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 4m2vA-4twlA:
28.6		 4m2vA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 4m2wA-4twlA:
28.6		 4m2wA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 3vxi DYP
(Bjerkandera
adusta) 		3 / 3 GLY A 320
PRO A 321
ALA A 190
 ASC  A 502 (-4.6A)
ASC  A 502 (-3.6A)
ASC  A 502 (-3.4A)
 0.33A 4qn9B-3vxiA:
undetectable		 4qn9B-3vxiA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RP8_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		11 / 11 THR A  86
TYR A  87
HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ASP A 314
ALA A 316
PHE A 362
MET A 410
 ASC  A 501 (-3.3A)
ASC  A 501 (-3.9A)
ASC  A 501 (-4.1A)
None
ASC  A 501 (-2.5A)
ASC  A 501 (-4.1A)
ASC  A 501 (-4.0A)
ASC  A 501 (-2.7A)
ASC  A 501 ( 3.7A)
ASC  A 501 (-3.4A)
ASC  A 501 (-4.1A)
 0.01A 4rp8A-4rp8A:
71.3		 4rp8A-4rp8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5zov -
(-) 		10 / 11 TYR A  87
HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ASP A 314
ALA A 316
PHE A 362
MET A 415
 ASC  A 501 (-4.0A)
ASC  A 501 (-4.0A)
None
ASC  A 501 (-3.1A)
ASC  A 501 (-4.0A)
ASC  A 501 (-4.2A)
ASC  A 501 (-2.7A)
ASC  A 501 (-3.6A)
ASC  A 501 (-3.8A)
ASC  A 501 ( 4.6A)
 0.32A 4rp8A-5zovA:
44.5		 4rp8A-5zovA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		10 / 12 THR A  86
HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ALA A 316
ILE A 358
PHE A 362
MET A 410
 ASC  A 501 (-3.3A)
ASC  A 501 (-4.1A)
None
ASC  A 501 (-2.5A)
ASC  A 501 (-4.1A)
ASC  A 501 (-4.0A)
ASC  A 501 ( 3.7A)
ASC  A 501 ( 4.9A)
ASC  A 501 (-3.4A)
ASC  A 501 (-4.1A)
 0.18A 4rp8C-4rp8A:
59.7		 4rp8C-4rp8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5zov -
(-) 		9 / 12 HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ALA A 316
ILE A 358
PHE A 362
MET A 415
 ASC  A 501 (-4.0A)
None
ASC  A 501 (-3.1A)
ASC  A 501 (-4.0A)
ASC  A 501 (-4.2A)
ASC  A 501 (-3.6A)
ASC  A 501 ( 4.9A)
ASC  A 501 (-3.8A)
ASC  A 501 ( 4.6A)
 0.35A 4rp8C-5zovA:
44.7		 4rp8C-5zovA:
62.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		12 / 12 THR A  86
TYR A  87
HIS A 135
ILE A 136
GLN A 139
GLN A 195
ASP A 314
CYH A 315
ALA A 316
ILE A 358
PHE A 362
MET A 410
 ASC  A 501 (-3.3A)
ASC  A 501 (-3.9A)
ASC  A 501 (-4.1A)
None
ASC  A 501 (-2.5A)
ASC  A 501 (-4.0A)
ASC  A 501 (-2.7A)
ASC  A 501 ( 4.5A)
ASC  A 501 ( 3.7A)
ASC  A 501 ( 4.9A)
ASC  A 501 (-3.4A)
ASC  A 501 (-4.1A)
 0.11A 4rp9A-4rp8A:
67.4		 4rp9A-4rp8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5zov -
(-) 		11 / 12 TYR A  87
HIS A 135
ILE A 136
GLN A 139
GLN A 195
ASP A 314
CYH A 315
ALA A 316
ILE A 358
PHE A 362
MET A 415
 ASC  A 501 (-4.0A)
ASC  A 501 (-4.0A)
None
ASC  A 501 (-3.1A)
ASC  A 501 (-4.2A)
ASC  A 501 (-2.7A)
ASC  A 501 ( 4.3A)
ASC  A 501 (-3.6A)
ASC  A 501 ( 4.9A)
ASC  A 501 (-3.8A)
ASC  A 501 ( 4.6A)
 0.35A 4rp9A-5zovA:
40.9		 4rp9A-5zovA:
62.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		5 / 12 THR A 366
GLN A 197
THR A 173
ILE A 136
HIS A 194
 None
None
None
None
ASC  A 501 (-4.1A)
 1.48A 4s0vA-4rp8A:
undetectable		 4s0vA-4rp8A:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWL_A_ASCA303_0
(DIOSCORIN 5)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		10 / 10 ASP A  70
HIS A  95
HIS A  97
GLN A 114
VAL A 116
VAL A 126
PHE A 182
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-3.5A)
ASC  A 303 (-2.7A)
ASC  A 303 (-4.4A)
ASC  A 303 (-4.1A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
None
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.00A 4twlA-4twlA:
45.1		 4twlA-4twlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWL_B_ASCB304_0
(DIOSCORIN 5)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		10 / 10 ASP A  70
HIS A  95
HIS A  97
GLN A 114
VAL A 116
VAL A 126
PHE A 182
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-3.5A)
ASC  A 303 (-2.7A)
ASC  A 303 (-4.4A)
ASC  A 303 (-4.1A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
None
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.17A 4twlB-4twlA:
42.0		 4twlB-4twlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWL_B_ASCB304_0
(DIOSCORIN 5)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 ASP A  70
HIS A  97
VAL A 116
PHE A 182
ALA A 184
 ASC  A 303 (-3.5A)
ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
None
ASC  A 303 (-3.0A)
 1.19A 4twlB-4twlA:
42.0		 4twlB-4twlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_A_AZMA299_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 4uovA-4twlA:
31.1		 4uovA-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_B_AZMB299_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.32A 4uovB-4twlA:
31.1		 4uovB-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_C_AZMC299_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 4uovC-4twlA:
31.1		 4uovC-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_D_AZMD299_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 4uovD-4twlA:
31.1		 4uovD-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_E_AZME299_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.32A 4uovE-4twlA:
31.2		 4uovE-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_F_AZMF299_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.32A 4uovF-4twlA:
31.3		 4uovF-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_A_AZMA302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 4x5sA-4twlA:
31.0		 4x5sA-4twlA:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_B_AZMB302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 4x5sB-4twlA:
31.0		 4x5sB-4twlA:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_A_AZMA402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 4xiwA-4twlA:
26.1
4xiwH-4twlA:
25.9		 4xiwA-4twlA:
34.50
4xiwH-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 4xiwB-4twlA:
26.1
4xiwE-4twlA:
26.0		 4xiwB-4twlA:
34.50
4xiwE-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_C_AZMC402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.37A 4xiwC-4twlA:
26.1		 4xiwC-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_D_AZMD402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 4xiwD-4twlA:
26.3		 4xiwD-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_E_AZME402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 4xiwE-4twlA:
26.0		 4xiwE-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_F_AZMF402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.29A 4xiwF-4twlA:
25.8		 4xiwF-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_G_AZMG402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.45A 4xiwG-4twlA:
25.9		 4xiwG-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_H_AZMH402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 4xiwH-4twlA:
25.9		 4xiwH-4twlA:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.43A 4ygfA-4twlA:
28.7		 4ygfA-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.49A 4ygfB-4twlA:
28.1		 4ygfB-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.37A 4ygfC-4twlA:
20.5		 4ygfC-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		7 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.36A 4ygfD-4twlA:
4.5		 4ygfD-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.43A 4ygfE-4twlA:
29.0		 4ygfE-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_F_AZMF303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 9 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.30A 4ygfF-4twlA:
28.4		 4ygfF-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.45A 4ygfG-4twlA:
28.7		 4ygfG-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_H_AZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 9 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 4ygfH-4twlA:
28.6		 4ygfH-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.43A 4yhaA-4twlA:
28.6		 4yhaA-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
 0.58A 4yhaB-4twlA:
27.6		 4yhaB-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.42A 4yhaC-4twlA:
29.1		 4yhaC-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.41A 4yhaD-4twlA:
27.8		 4yhaD-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		7 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
None
ASC  A 303 (-4.3A)
 0.44A 4yhaE-4twlA:
28.9		 4yhaE-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 126
THR A 183
ALA A 184
PRO A 186
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
None
 0.96A 4yhaE-4twlA:
28.9		 4yhaE-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.53A 4yhaF-4twlA:
26.1		 4yhaF-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.43A 4yhaG-4twlA:
28.1		 4yhaG-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 10 HIS A  97
GLU A 101
VAL A 116
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.44A 4yhaH-4twlA:
28.6		 4yhaH-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		7 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.30A 5c8iA-4twlA:
28.6		 5c8iA-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JCN_A_ASCA502_0
(OS09G0567300 PROTEIN)		 5jcn OS09G0567300 PROTEIN
(Oryza
sativa) 		5 / 5 GLU A  47
PRO A  49
ARG A 320
PHE A 349
ARG A 351
 None
FAD  A 500 ( 3.6A)
ASC  A 502 (-2.8A)
FAD  A 500 (-3.7A)
ASC  A 502 (-4.0A)
 0.00A 5jcnA-5jcnA:
66.9		 5jcnA-5jcnA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 5jcn OS09G0567300 PROTEIN
(Oryza
sativa) 		6 / 6 GLU A  47
PRO A  49
GLY A  72
ARG A 320
PHE A 349
ARG A 351
 None
FAD  A 500 ( 3.6A)
ASC  A 502 (-4.0A)
ASC  A 502 (-2.8A)
FAD  A 500 (-3.7A)
ASC  A 502 (-4.0A)
 0.15A 5jcnB-5jcnA:
62.6		 5jcnB-5jcnA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 5jt4 CYTOCHROME C'
(Achromobacter
xylosoxidans) 		5 / 5 ALA A  20
GLY A 113
CYH A 116
LYS A 117
HIS A 120
 ASC  A 202 ( 3.3A)
ASC  A 202 (-3.9A)
HEC  A 201 (-1.9A)
None
HEC  A 201 (-3.2A)
 0.17A 5jliA-5jt4A:
25.2		 5jliA-5jt4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN8_A_AZMA701_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.37A 5jn8A-4twlA:
26.7		 5jn8A-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN8_B_AZMB701_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 5jn8B-4twlA:
26.7		 5jn8B-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN8_D_AZMD701_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 5jn8D-4twlA:
26.5		 5jn8D-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN9_A_EZLA302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 5jn9A-4twlA:
26.7		 5jn9A-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN9_B_EZLB302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 5jn9B-4twlA:
26.9		 5jn9B-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN9_D_EZLD302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 5jn9D-4twlA:
26.4		 5jn9D-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
 0.32A 5jnaA-4twlA:
26.6		 5jnaA-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.39A 5jnaB-4twlA:
26.7		 5jnaB-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.39A 5jnaD-4twlA:
26.4		 5jnaD-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_6LHA302_0
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 5jncA-4twlA:
26.7		 5jncA-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_B_6LHB302_0
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 5jncB-4twlA:
26.8		 5jncB-4twlA:
28.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JRA_A_ASCA202_0
(CYTOCHROME C')		 5jt4 CYTOCHROME C'
(Achromobacter
xylosoxidans) 		4 / 4 GLY A 113
CYH A 116
LYS A 117
HIS A 120
 ASC  A 202 (-3.9A)
HEC  A 201 (-1.9A)
None
HEC  A 201 (-3.2A)
 0.12A 5jraA-5jt4A:
24.6		 5jraA-5jt4A:
99.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JSL_A_ASCA202_0
(CYTOCHROME C')		 5jt4 CYTOCHROME C'
(Achromobacter
xylosoxidans) 		4 / 4 ALA A  20
GLY A 113
CYH A 116
HIS A 120
 ASC  A 202 ( 3.3A)
ASC  A 202 (-3.9A)
HEC  A 201 (-1.9A)
HEC  A 201 (-3.2A)
 0.07A 5jslA-5jt4A:
25.0		 5jslA-5jt4A:
99.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 5jt4 CYTOCHROME C'
(Achromobacter
xylosoxidans) 		5 / 5 ALA A  20
GLY A 113
CYH A 116
LYS A 117
HIS A 120
 ASC  A 202 ( 3.3A)
ASC  A 202 (-3.9A)
HEC  A 201 (-1.9A)
None
HEC  A 201 (-3.2A)
 0.02A 5jt4A-5jt4A:
26.1		 5jt4A-5jt4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 5ku6A-4twlA:
26.7		 5ku6A-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_B_MZMB302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 5ku6B-4twlA:
26.8		 5ku6B-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  95
VAL A 116
THR A 183
ALA A 184
PRO A 186
 ASC  A 303 (-2.7A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
None
 0.92A 5tt3A-4twlA:
28.6		 5tt3A-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		7 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
None
ASC  A 303 (-4.3A)
 0.37A 5tt3A-4twlA:
28.6		 5tt3A-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_B_EZLB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 9 HIS A  95
HIS A  97
VAL A 116
THR A 183
ALA A 184
 ASC  A 303 (-2.7A)
ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
 0.89A 5tt3B-4twlA:
26.7		 5tt3B-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_B_EZLB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 9 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.54A 5tt3B-4twlA:
26.7		 5tt3B-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
THR A 183
ALA A 184
PRO A 186
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
None
 0.70A 5tt3C-4twlA:
28.9		 5tt3C-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		7 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
None
ASC  A 303 (-4.3A)
 0.37A 5tt3C-4twlA:
28.9		 5tt3C-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 9 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.47A 5tt3E-4twlA:
28.8		 5tt3E-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 8 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 5tt3F-4twlA:
27.9		 5tt3F-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 9 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.44A 5tt3G-4twlA:
28.0		 5tt3G-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 8 HIS A  97
VAL A 116
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.42A 5tt3H-4twlA:
28.3		 5tt3H-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5zov -
(-) 		4 / 7 HIS A 194
GLN A 196
MET A 413
MET A 131
 ASC  A 501 (-4.0A)
None
None
None
 1.47A 5u6mA-5zovA:
undetectable		 5u6mA-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		4 / 7 HIS A 194
GLN A 196
MET A 408
MET A 131
 ASC  A 501 (-4.1A)
None
None
None
 1.40A 5u6mB-4rp8A:
undetectable		 5u6mB-4rp8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5zov -
(-) 		4 / 7 HIS A 194
GLN A 196
MET A 413
MET A 131
 ASC  A 501 (-4.0A)
None
None
None
 1.39A 5u6mB-5zovA:
undetectable		 5u6mB-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5zov -
(-) 		4 / 8 HIS A 194
GLN A 196
MET A 413
MET A 131
 ASC  A 501 (-4.0A)
None
None
None
 1.42A 5u6nA-5zovA:
undetectable		 5u6nA-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		5 / 11 PHE A 362
MET A 408
GLY A 409
GLN A 196
GLU A 391
 ASC  A 501 (-3.4A)
None
None
None
None
 1.39A 5x19G-4rp8A:
undetectable
5x19N-4rp8A:
0.8
5x19O-4rp8A:
undetectable		 5x19G-4rp8A:
13.14
5x19N-4rp8A:
25.09
5x19O-4rp8A:
18.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZOV_A_ASCA501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		9 / 10 TYR A  87
HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ASP A 314
ALA A 316
ILE A 358
 ASC  A 501 (-3.9A)
ASC  A 501 (-4.1A)
None
ASC  A 501 (-2.5A)
ASC  A 501 (-4.1A)
ASC  A 501 (-4.0A)
ASC  A 501 (-2.7A)
ASC  A 501 ( 3.7A)
ASC  A 501 ( 4.9A)
 0.35A 5zovA-4rp8A:
44.5		 5zovA-4rp8A:
62.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_A_ASCA501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 5zov -
(-) 		10 / 10 TYR A  87
HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ARG A 288
ASP A 314
ALA A 316
ILE A 358
 ASC  A 501 (-4.0A)
ASC  A 501 (-4.0A)
None
ASC  A 501 (-3.1A)
ASC  A 501 (-4.0A)
ASC  A 501 (-4.2A)
ASC  A 501 (-3.0A)
ASC  A 501 (-2.7A)
ASC  A 501 (-3.6A)
ASC  A 501 ( 4.9A)
 0.01A 5zovA-5zovA:
74.7		 5zovA-5zovA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA
(Escherichia
coli) 		10 / 12 TYR A  87
HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ASP A 314
ALA A 316
ILE A 358
MET A 410
 ASC  A 501 (-3.9A)
ASC  A 501 (-4.1A)
None
ASC  A 501 (-2.5A)
ASC  A 501 (-4.1A)
ASC  A 501 (-4.0A)
ASC  A 501 (-2.7A)
ASC  A 501 ( 3.7A)
ASC  A 501 ( 4.9A)
ASC  A 501 (-4.1A)
 0.33A 5zovB-4rp8A:
44.1		 5zovB-4rp8A:
62.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 5zov -
(-) 		12 / 12 PRO A  86
TYR A  87
HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ARG A 288
ASP A 314
ALA A 316
ILE A 358
MET A 415
 None
ASC  A 501 (-4.0A)
ASC  A 501 (-4.0A)
None
ASC  A 501 (-3.1A)
ASC  A 501 (-4.0A)
ASC  A 501 (-4.2A)
ASC  A 501 (-3.0A)
ASC  A 501 (-2.7A)
ASC  A 501 (-3.6A)
ASC  A 501 ( 4.9A)
ASC  A 501 ( 4.6A)
 0.33A 5zovB-5zovA:
69.7		 5zovB-5zovA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.32A 6bccA-4twlA:
28.6		 6bccA-4twlA:
16.67