SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ARS'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P5Z_B_AR3B304_1 (DEOXYCYTIDINE KINASE)	2y0o	PROBABLE D-LYXOSE KETOL-ISOMERASE (Bacillus subtilis)	5 / 12	GLU A 150 LEU A 42 MET A 30 TYR A 32 GLN A 28	ARS A1176 (-4.1A) None None None None	1.16A	1p5zB-2y0oA: undetectable	1p5zB-2y0oA: 21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q0Y_H_MOIH401_1 (FAB 9B1, HEAVY CHAIN FAB 9B1, LIGHT CHAIN)	2y0o	PROBABLE D-LYXOSE KETOL-ISOMERASE (Bacillus subtilis)	4 / 7	GLU A 150 GLU A 82 ILE A 131 LEU A 42	ARS A1176 (-4.1A) ZN A1173 (-2.6A) None None	1.33A	1q0yH-2y0oA: undetectable 1q0yL-2y0oA: undetectable	1q0yH-2y0oA: 20.91 1q0yL-2y0oA: 21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOS_A_VIAA1_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	9 / 12	TYR A 233 HIS A 234 MET A 347 ASP A 392 MET A 411 PHE A 414 SER A 429 GLN A 443 PHE A 446	None None ZG2 A 506 (-3.9A) ZN A 1 (-2.6A) None ZG2 A 506 (-4.4A) ARS A 3 (-4.4A) ZG2 A 506 (-3.3A) ZG2 A 506 (-3.6A)	0.91A	1xosA-3o57A: 53.2	1xosA-3o57A: 93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOT_A_VDNA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	12 / 12	TYR A 233 HIS A 234 MET A 347 LEU A 393 ILE A 410 MET A 411 SER A 429 MET A 431 SER A 442 GLN A 443 PHE A 446 ILE A 450	None None ZG2 A 506 (-3.9A) None ZG2 A 506 (-4.4A) None ARS A 3 (-4.4A) ZG2 A 506 (-3.4A) None ZG2 A 506 (-3.3A) ZG2 A 506 (-3.6A) None	0.66A	1xotA-3o57A: 53.5	1xotA-3o57A: 93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOT_B_VDNB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	10 / 12	TYR A 233 HIS A 234 ASN A 395 ILE A 410 MET A 411 SER A 429 MET A 431 SER A 442 GLN A 443 PHE A 446	None None ZG2 A 506 (-4.3A) ZG2 A 506 (-4.4A) None ARS A 3 (-4.4A) ZG2 A 506 (-3.4A) None ZG2 A 506 (-3.3A) ZG2 A 506 (-3.6A)	0.75A	1xotB-3o57A: 53.4	1xotB-3o57A: 93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOT_B_VDNB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	11 / 12	TYR A 233 HIS A 234 MET A 347 LEU A 393 ASN A 395 ILE A 410 MET A 411 SER A 429 SER A 442 GLN A 443 PHE A 446	None None ZG2 A 506 (-3.9A) None ZG2 A 506 (-4.3A) ZG2 A 506 (-4.4A) None ARS A 3 (-4.4A) None ZG2 A 506 (-3.3A) ZG2 A 506 (-3.6A)	0.56A	1xotB-3o57A: 53.4	1xotB-3o57A: 93.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NO0_A_GEOA302_1 (DEOXYCYTIDINE KINASE)	2y0o	PROBABLE D-LYXOSE KETOL-ISOMERASE (Bacillus subtilis)	5 / 12	GLU A 150 LEU A 42 MET A 30 TYR A 32 GLN A 28	ARS A1176 (-4.1A) None None None None	1.18A	2no0A-2y0oA: undetectable	2no0A-2y0oA: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NO0_B_GEOB302_1 (DEOXYCYTIDINE KINASE)	2y0o	PROBABLE D-LYXOSE KETOL-ISOMERASE (Bacillus subtilis)	5 / 12	GLU A 150 LEU A 42 MET A 30 TYR A 32 GLN A 28	ARS A1176 (-4.1A) None None None None	1.20A	2no0B-2y0oA: undetectable	2no0B-2y0oA: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NO6_A_ETVA302_1 (DEOXYCYTIDINE KINASE)	2y0o	PROBABLE D-LYXOSE KETOL-ISOMERASE (Bacillus subtilis)	5 / 12	GLU A 150 LEU A 42 MET A 30 TYR A 32 GLN A 28	ARS A1176 (-4.1A) None None None None	1.22A	2no6A-2y0oA: undetectable	2no6A-2y0oA: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NO6_B_ETVB302_1 (DEOXYCYTIDINE KINASE)	2y0o	PROBABLE D-LYXOSE KETOL-ISOMERASE (Bacillus subtilis)	5 / 11	GLU A 150 LEU A 42 MET A 30 TYR A 32 GLN A 28	ARS A1176 (-4.1A) None None None None	1.29A	2no6B-2y0oA: undetectable	2no6B-2y0oA: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NOA_A_3TCA302_1 (DEOXYCYTIDINE KINASE)	2y0o	PROBABLE D-LYXOSE KETOL-ISOMERASE (Bacillus subtilis)	5 / 12	GLU A 150 LEU A 42 MET A 30 TYR A 32 GLN A 28	ARS A1176 (-4.1A) None None None None	1.22A	2noaA-2y0oA: undetectable	2noaA-2y0oA: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q0I_A_BEZA990_0 (QUINOLONE SIGNAL RESPONSE PROTEIN)	4r0v	FE-HYDROGENASE (Chlamydomonas reinhardtii)	4 / 8	ASP A 160 GLU A 144 SER A 190 HIS A 482	ARS A 604 ( 4.8A) None None None	0.86A	2q0iA-4r0vA: undetectable	2q0iA-4r0vA: 20.70

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1P5Z_B_AR3B304_1","DEOXYCYTIDINE KINASE","2y0o","PROBABLE D-LYXOSE KETOL-ISOMERASE","Bacillus subtilis",5,"GLU A 150;LEU A  42;MET A  30;TYR A  32;GLN A  28","ARS A1176 (-4.1A);None;None;None;None","1.16A","1p5zB-2y0oA:undetectable",null],["1Q0Y_H_MOIH401_1","FAB 9B1, HEAVY CHAIN;FAB 9B1, LIGHT CHAIN","2y0o","PROBABLE D-LYXOSE KETOL-ISOMERASE","Bacillus subtilis",4,"GLU A 150;GLU A  82;ILE A 131;LEU A  42","ARS A1176 (-4.1A); ZN A1173 (-2.6A);None;None","1.33A","1q0yH-2y0oA:undetectable;1q0yL-2y0oA:undetectable","1p5zB-2y0oA:21.19"],["1XOS_A_VIAA1_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B","3o57","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B","Homo sapiens",9,"TYR A 233;HIS A 234;MET A 347;ASP A 392;MET A 411;PHE A 414;SER A 429;GLN A 443;PHE A 446","None;None;ZG2 A 506 (-3.9A); ZN A   1 (-2.6A);None;ZG2 A 506 (-4.4A);ARS A   3 (-4.4A);ZG2 A 506 (-3.3A);ZG2 A 506 (-3.6A)","0.91A","1xosA-3o57A:53.2","1q0yH-2y0oA:20.91;1q0yL-2y0oA:21.76"],["1XOT_A_VDNA101_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B","3o57","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B","Homo sapiens",12,"TYR A 233;HIS A 234;MET A 347;LEU A 393;ILE A 410;MET A 411;SER A 429;MET A 431;SER A 442;GLN A 443;PHE A 446;ILE A 450","None;None;ZG2 A 506 (-3.9A);None;ZG2 A 506 (-4.4A);None;ARS A   3 (-4.4A);ZG2 A 506 (-3.4A);None;ZG2 A 506 (-3.3A);ZG2 A 506 (-3.6A);None","0.66A","1xotA-3o57A:53.5","1xosA-3o57A:93.83"],["1XOT_B_VDNB102_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B","3o57","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B","Homo sapiens",10,"TYR A 233;HIS A 234;ASN A 395;ILE A 410;MET A 411;SER A 429;MET A 431;SER A 442;GLN A 443;PHE A 446","None;None;ZG2 A 506 (-4.3A);ZG2 A 506 (-4.4A);None;ARS A   3 (-4.4A);ZG2 A 506 (-3.4A);None;ZG2 A 506 (-3.3A);ZG2 A 506 (-3.6A)","0.75A","1xotB-3o57A:53.4","1xotA-3o57A:93.83"],["1XOT_B_VDNB102_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B","3o57","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B","Homo sapiens",11,"TYR A 233;HIS A 234;MET A 347;LEU A 393;ASN A 395;ILE A 410;MET A 411;SER A 429;SER A 442;GLN A 443;PHE A 446","None;None;ZG2 A 506 (-3.9A);None;ZG2 A 506 (-4.3A);ZG2 A 506 (-4.4A);None;ARS A   3 (-4.4A);None;ZG2 A 506 (-3.3A);ZG2 A 506 (-3.6A)","0.56A","1xotB-3o57A:53.4","1xotB-3o57A:93.83"],["2NO0_A_GEOA302_1","DEOXYCYTIDINE KINASE","2y0o","PROBABLE D-LYXOSE KETOL-ISOMERASE","Bacillus subtilis",5,"GLU A 150;LEU A  42;MET A  30;TYR A  32;GLN A  28","ARS A1176 (-4.1A);None;None;None;None","1.18A","2no0A-2y0oA:undetectable","1xotB-3o57A:93.83"],["2NO0_B_GEOB302_1","DEOXYCYTIDINE KINASE","2y0o","PROBABLE D-LYXOSE KETOL-ISOMERASE","Bacillus subtilis",5,"GLU A 150;LEU A  42;MET A  30;TYR A  32;GLN A  28","ARS A1176 (-4.1A);None;None;None;None","1.20A","2no0B-2y0oA:undetectable","2no0A-2y0oA:19.72"],["2NO6_A_ETVA302_1","DEOXYCYTIDINE KINASE","2y0o","PROBABLE D-LYXOSE KETOL-ISOMERASE","Bacillus subtilis",5,"GLU A 150;LEU A  42;MET A  30;TYR A  32;GLN A  28","ARS A1176 (-4.1A);None;None;None;None","1.22A","2no6A-2y0oA:undetectable","2no0B-2y0oA:19.72"],["2NO6_B_ETVB302_1","DEOXYCYTIDINE KINASE","2y0o","PROBABLE D-LYXOSE KETOL-ISOMERASE","Bacillus subtilis",5,"GLU A 150;LEU A  42;MET A  30;TYR A  32;GLN A  28","ARS A1176 (-4.1A);None;None;None;None","1.29A","2no6B-2y0oA:undetectable","2no6A-2y0oA:19.72"],["2NOA_A_3TCA302_1","DEOXYCYTIDINE KINASE","2y0o","PROBABLE D-LYXOSE KETOL-ISOMERASE","Bacillus subtilis",5,"GLU A 150;LEU A  42;MET A  30;TYR A  32;GLN A  28","ARS A1176 (-4.1A);None;None;None;None","1.22A","2noaA-2y0oA:undetectable","2no6B-2y0oA:19.72"],["2Q0I_A_BEZA990_0","QUINOLONE SIGNAL RESPONSE PROTEIN","4r0v","FE-HYDROGENASE","Chlamydomonas reinhardtii",4,"ASP A 160;GLU A 144;SER A 190;HIS A 482","ARS A 604 ( 4.8A);None;None;None","0.86A","2q0iA-4r0vA:undetectable","2noaA-2y0oA:19.72"]]