SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ARA'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 11 ASP A 123
GLY A 142
THR A 140
GLY A 175
GLN A 179
 ARA  A 401 (-2.7A)
None
None
None
None
 1.44A 1jr1A-4rxtA:
undetectable		 1jr1A-4rxtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 11 ASP A 123
GLY A 143
THR A 140
GLY A 175
GLN A 179
 ARA  A 401 (-2.7A)
None
None
None
None
 1.40A 1jr1A-4rxtA:
undetectable		 1jr1A-4rxtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A 134
GLU A 167
TRP A  69
HIS A  90
 ARA  A 605 ( 4.0A)
None
None
None
 0.90A 1maaD-5la0A:
undetectable		 1maaD-5la0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 411
ASN A 507
TRP A 481
 ARA  A 606 (-2.8A)
ARA  A 606 (-3.0A)
None
 1.26A 1r15C-5la0A:
1.8		 1r15C-5la0A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A 411
ASN A 507
TRP A 481
 ARA  A 606 (-2.8A)
ARA  A 606 (-3.0A)
None
 1.29A 1r15E-5la0A:
2.0		 1r15E-5la0A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 9 ASN A 231
ILE A 233
ALA A 207
GLN A 236
THR A 262
 ARA  A 401 (-3.7A)
None
None
None
None
 1.39A 2dtjA-4rxtA:
undetectable
2dtjB-4rxtA:
undetectable		 2dtjA-4rxtA:
21.90
2dtjB-4rxtA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3das PUTATIVE
OXIDOREDUCTASE
(Streptomyces
coelicolor) 		5 / 10 ASP A 329
ARG A 311
ILE A 268
ILE A 288
GLY A 282
 PQQ  A4331 ( 4.9A)
PQQ  A4331 (-2.9A)
None
None
ARA  A 349 (-4.1A)
 1.30A 2v0mA-3dasA:
undetectable		 2v0mA-3dasA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 5la0 CARBOHYDRATE BINDING
FAMILY 6
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A 170
GLU A 171
HIS A 253
TYR A 255
GLU A 279
 ARA  A 605 (-4.3A)
None
None
None
ARA  A 605 ( 4.4A)
 0.30A 2v3dA-5la0A:
14.7		 2v3dA-5la0A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 10 PRO A 172
ARG A 180
GLY A 205
GLY A 175
ALA A 174
 None
ARA  A 401 (-3.0A)
None
None
None
 1.50A 3pp7B-4rxtA:
3.7		 3pp7B-4rxtA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 9 ALA A 235
ALA A 229
LEU A 177
LEU A 274
VAL A 275
 None
None
ARA  A 401 ( 4.6A)
None
None
 1.32A 4or0A-4rxtA:
undetectable		 4or0A-4rxtA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 4rxt SUGAR ABC
TRANSPORTER
(Agrobacterium
tumefaciens) 		5 / 11 PHE A 228
TYR A  48
GLY A 143
SER A 230
GLY A 255
 None
ARA  A 401 (-3.7A)
None
None
None
 1.00A 4xp4A-4rxtA:
undetectable		 4xp4A-4rxtA:
21.40