SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AR6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		5 / 12 LEU A  94
THR A  76
LEU A 123
LEU A 117
GLY A 116
 None
AR6  A 280 (-4.3A)
None
None
None
 1.14A 1d4fD-3sigA:
undetectable		 1d4fD-3sigA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		5 / 12 GLY A  61
SER A  65
SER A 157
LEU A 139
HIS A 124
 AR6  A 401 (-3.3A)
None
EDO  A 406 (-2.6A)
None
None
 0.97A 1ya4A-5oj7A:
undetectable		 1ya4A-5oj7A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 6 ALA A  62
SER A  65
ASN A 143
ASP A 145
 AR6  A 401 (-3.6A)
None
None
None
 0.30A 1yc2A-5oj7A:
24.5		 1yc2A-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		5 / 7 ALA A  62
SER A  65
ILE A  70
ASN A 143
ASP A 145
 AR6  A 401 (-3.6A)
None
None
None
None
 0.30A 1yc5A-5oj7A:
8.9		 1yc5A-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		5 / 7 SER A  65
ILE A  70
ASP A  72
ASN A 143
ASP A 145
 None
None
AR6  A 401 (-3.7A)
None
None
 0.76A 1yc5A-5oj7A:
8.9		 1yc5A-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		4 / 5 CYH A 207
PRO A 108
THR A 255
THR A 222
 AR6  A1262 ( 4.5A)
AR6  A1262 (-4.7A)
None
None
 1.46A 1ymxB-5fsyA:
undetectable		 1ymxB-5fsyA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3q71 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		4 / 5 ALA A1131
ASN A1178
ILE A1179
ASP A1175
 AR6  A 800 (-4.2A)
AR6  A 800 (-4.2A)
None
AR6  A 800 (-3.4A)
 1.00A 2h4jA-3q71A:
undetectable		 2h4jA-3q71A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		4 / 5 ALA A  62
ILE A  70
ASN A 143
ASP A 145
 AR6  A 401 (-3.6A)
None
None
None
 0.26A 2h4jA-5oj7A:
22.9		 2h4jA-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		4 / 6 THR A  75
ASP A 161
SER A 120
VAL A 157
 AR6  A 280 (-4.4A)
None
None
None
 1.20A 2hdnI-3sigA:
undetectable
2hdnJ-3sigA:
undetectable
2hdnL-3sigA:
undetectable		 2hdnI-3sigA:
9.52
2hdnJ-3sigA:
22.93
2hdnL-3sigA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		4 / 6 SER A 120
VAL A 157
THR A  75
ASP A 161
 None
None
AR6  A 280 (-4.4A)
None
 1.16A 2hdnJ-3sigA:
undetectable
2hdnK-3sigA:
undetectable
2hdnL-3sigA:
undetectable		 2hdnJ-3sigA:
22.93
2hdnK-3sigA:
9.52
2hdnL-3sigA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE
(Xenopus
tropicalis) 		5 / 12 ILE A  64
GLY A 259
ALA A 291
ILE A 281
VAL A 140
 None
AR6  A 401 (-3.6A)
None
None
None
 1.17A 3adsB-5oj7A:
undetectable		 3adsB-5oj7A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4iqy O-ACETYL-ADP-RIBOSE
DEACETYLASE MACROD2
(Homo
sapiens) 		4 / 8 GLY A  98
GLY A 103
HIS A 106
ILE A 105
 AR6  A 301 ( 3.7A)
None
None
None
 0.68A 3d41A-4iqyA:
undetectable		 3d41A-4iqyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		6 / 12 GLY A 104
ALA A 118
LEU A 123
ASN A  95
PRO A 178
PHE A 133
 AR6  A 280 (-3.3A)
None
None
None
None
None
 1.46A 3dmhA-3sigA:
undetectable		 3dmhA-3sigA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		4 / 8 SER A 120
VAL A 157
THR A  76
VAL A 172
 None
None
AR6  A 280 (-4.3A)
None
 1.15A 3fhxB-3sigA:
undetectable		 3fhxB-3sigA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4abk POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 12 GLY A1257
ALA A1261
THR A1237
ILE A1244
ILE A1326
 AR6  A2389 (-3.4A)
AR6  A2389 (-3.5A)
None
None
None
 1.33A 3ld6A-4abkA:
undetectable		 3ld6A-4abkA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		5 / 12 ARG A 124
GLY A 152
ARG A 159
VAL A 213
TYR A 214
 None
None
None
AR6  A1262 (-3.7A)
AR6  A1262 (-3.5A)
 1.44A 4ffwA-5fsyA:
undetectable		 4ffwA-5fsyA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 4abk POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 9 VAL A1258
ILE A1262
LEU A1263
ILE A1236
GLY A1290
 AR6  A2389 (-3.9A)
None
None
AR6  A2389 (-3.9A)
None
 1.11A 4kukA-4abkA:
undetectable		 4kukA-4abkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		5 / 11 GLY A 105
GLY A 104
GLY A 103
ALA A 110
GLN A 113
 None
AR6  A 280 (-3.3A)
None
AR6  A 280 ( 4.9A)
None
 0.90A 4l8fB-3sigA:
undetectable		 4l8fB-3sigA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		5 / 11 GLY A 105
GLY A 104
GLY A 103
ALA A 110
HIS A 111
 None
AR6  A 280 (-3.3A)
None
AR6  A 280 ( 4.9A)
None
 1.08A 4l8fB-3sigA:
undetectable		 4l8fB-3sigA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		5 / 11 GLY A 105
GLY A 104
GLY A 103
ALA A 110
HIS A 111
 None
AR6  A 280 (-3.3A)
None
AR6  A 280 ( 4.9A)
None
 1.07A 4l8fD-3sigA:
undetectable		 4l8fD-3sigA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3q71 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 12 GLY A1133
GLY A1135
PRO A1045
LEU A1046
MET A1108
 AR6  A 800 (-3.4A)
AR6  A 800 (-3.1A)
AR6  A 800 (-3.3A)
AR6  A 800 (-3.6A)
None
 1.21A 4x61A-3q71A:
2.9		 4x61A-3q71A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 5lw0 BASIC
HELIX-LOOP-HELIX,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		5 / 12 LEU A 238
VAL A 250
ILE A 176
VAL A 256
LEU A 287
 None
None
AR6  A 301 (-4.0A)
None
None
 0.97A 4y0pA-5lw0A:
undetectable		 4y0pA-5lw0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4iqy O-ACETYL-ADP-RIBOSE
DEACETYLASE MACROD2
(Homo
sapiens) 		5 / 12 VAL A 101
ASP A 102
THR A 204
GLY A 146
LEU A 161
 AR6  A 301 (-3.9A)
AR6  A 301 (-3.6A)
None
None
None
 1.30A 5m50E-4iqyA:
2.1		 5m50E-4iqyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4iqy O-ACETYL-ADP-RIBOSE
DEACETYLASE MACROD2
(Homo
sapiens) 		4 / 6 THR A  80
ARG A  32
ASP A 135
GLY A 110
 AR6  A 301 ( 4.8A)
None
None
None
 0.84A 5mraA-4iqyA:
undetectable
5mraB-4iqyA:
undetectable		 5mraA-4iqyA:
20.33
5mraB-4iqyA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5fsy MACRODOMAIN
(Trypanosoma
brucei) 		5 / 12 ILE A 192
VAL A 209
LEU A 218
VAL A 260
ILE A 102
 None
AR6  A1262 ( 4.5A)
None
None
None
 0.76A 5mugA-5fsyA:
undetectable		 5mugA-5fsyA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3q71 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens) 		5 / 10 VAL A1031
ALA A1128
LEU A1084
LEU A1046
LEU A1050
 None
None
None
AR6  A 800 (-3.6A)
None
 0.99A 6f5uA-3q71A:
undetectable
6f5uB-3q71A:
undetectable		 6f5uA-3q71A:
19.15
6f5uB-3q71A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 5lw0 BASIC
HELIX-LOOP-HELIX,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		4 / 7 SER A 109
ALA A 283
ILE A 254
ALA A 191
 AR6  A 301 (-4.2A)
None
None
None
 0.91A 6ma7A-5lw0A:
undetectable		 6ma7A-5lw0A:
17.04