SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'APU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 5 THR A  23
GLU A 168
THR A 169
LEU A 163
 APU  A 200 ( 4.6A)
None
None
None
 1.29A 1d4fC-1dtpA:
undetectable		 1d4fC-1dtpA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 7 HIS A  21
GLY A  22
ALA A  62
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.7A)
APU  A 200 ( 3.6A)
None
 0.61A 1dmaA-1dtpA:
9.7		 1dmaA-1dtpA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 7 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.46A 1dmaA-1dtpA:
9.7		 1dmaA-1dtpA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 6 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.54A 1dmaB-1dtpA:
9.2		 1dmaB-1dtpA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 6 PRO A  25
ILE A  31
ASN A 166
LEU A 163
 None
APU  A 200 ( 3.7A)
None
None
 1.00A 2wekB-1dtpA:
undetectable		 2wekB-1dtpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 HIS A  21
GLY A  22
TYR A  54
TYR A  65
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
 0.62A 3u9hA-1dtpA:
6.3		 3u9hA-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 HIS A  21
GLY A  22
TYR A  54
TYR A  65
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
 0.68A 3u9hB-1dtpA:
6.2		 3u9hB-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 HIS A  21
GLY A  22
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.88A 3u9hB-1dtpA:
6.2		 3u9hB-1dtpA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		6 / 6 HIS A  21
GLY A  22
TYR A  54
ALA A  62
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.7A)
APU  A 200 ( 3.6A)
None
 0.50A 4ae1A-1dtpA:
24.3		 4ae1A-1dtpA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 5 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.41A 4ae1B-1dtpA:
22.9		 4ae1B-1dtpA:
99.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 HIS A  21
GLY A  22
TYR A  54
TYR A  65
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
 0.53A 4bjcA-1dtpA:
5.6		 4bjcA-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		4 / 8 HIS A  21
GLY A  22
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.86A 4bjcA-1dtpA:
5.6		 4bjcA-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 7 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.81A 4hyfA-1dtpA:
5.7		 4hyfA-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 8 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.83A 4hyfB-1dtpA:
5.8		 4hyfB-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 8 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.79A 4hyfC-1dtpA:
5.8		 4hyfC-1dtpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 11 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.46A 4rv6A-1dtpA:
6.3		 4rv6A-1dtpA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1dtp DIPHTHERIA TOXIN
(Corynephage
beta) 		5 / 11 HIS A  21
GLY A  22
TYR A  54
TYR A  65
GLU A 148
 APU  A 200 ( 3.3A)
APU  A 200 ( 4.0A)
APU  A 200 ( 4.0A)
APU  A 200 ( 3.6A)
None
 0.46A 4rv6B-1dtpA:
6.6		 4rv6B-1dtpA:
20.68