SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'APT'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1MRG_A_ADNA300_1 (ALPHA-MOMORCHARIN)	1qcj	POKEWEED ANTIVIRAL PROTEIN (Phytolacca americana)	5 / 9	PHE A 90 TYR A 123 ILE A 171 GLU A 176 ARG A 179	APT A 901 ( 4.7A) APT A 901 (-4.7A) APT A 901 (-3.7A) APT A 901 ( 3.6A) APT A 901 (-3.0A)	0.46A	1mrgA-1qcjA: 30.6	1mrgA-1qcjA: 31.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MRJ_A_ADNA300_1 (ALPHA-TRICHOSANTHIN)	1qcj	POKEWEED ANTIVIRAL PROTEIN (Phytolacca americana)	4 / 8	TYR A 123 ILE A 171 GLU A 176 ARG A 179	APT A 901 (-4.7A) APT A 901 (-3.7A) APT A 901 ( 3.6A) APT A 901 (-3.0A)	0.33A	1mrjA-1qcjA: 30.4	1mrjA-1qcjA: 28.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MRJ_A_ADNA300_1 (ALPHA-TRICHOSANTHIN)	1qcj	POKEWEED ANTIVIRAL PROTEIN (Phytolacca americana)	4 / 8	TYR A 123 ILE A 171 SER A 175 ARG A 179	APT A 901 (-4.7A) APT A 901 (-3.7A) APT A 901 (-1.7A) APT A 901 (-3.0A)	0.65A	1mrjA-1qcjA: 30.4	1mrjA-1qcjA: 28.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T9U_A_CPFA5002_1 (ACRIFLAVINE RESISTANCE PROTEIN B)	1qcj	POKEWEED ANTIVIRAL PROTEIN (Phytolacca americana)	4 / 6	PHE A 90 ASN A 91 ARG A 67 ASN A 70	APT A 901 ( 4.7A) None None None	1.37A	1t9uA-1qcjA: 0.0	1t9uA-1qcjA: 12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q5S_A_ACHA1289_0 (MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR)	1qcj	POKEWEED ANTIVIRAL PROTEIN (Phytolacca americana)	4 / 6	ASN A 198 TYR A 123 GLU A 176 ILE A 183	None APT A 901 (-4.7A) APT A 901 ( 3.6A) None	1.06A	3q5sA-1qcjA: undetectable	3q5sA-1qcjA: 22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3U6T_A_KANA4699_1 (RIBOSOME INACTIVATING PROTEIN)	1qcj	POKEWEED ANTIVIRAL PROTEIN (Phytolacca americana)	5 / 10	TYR A 72 TYR A 123 ILE A 171 GLU A 176 ARG A 179	APT A 901 (-3.9A) APT A 901 (-4.7A) APT A 901 (-3.7A) APT A 901 ( 3.6A) APT A 901 (-3.0A)	0.59A	3u6tA-1qcjA: 30.9	3u6tA-1qcjA: 30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4O0O_A_URFA303_1 (RRNA N-GLYCOSIDASE)	1qcj	POKEWEED ANTIVIRAL PROTEIN (Phytolacca americana)	4 / 5	TYR A 72 TYR A 123 ILE A 171 ARG A 179	APT A 901 (-3.9A) APT A 901 (-4.7A) APT A 901 (-3.7A) APT A 901 (-3.0A)	0.37A	4o0oA-1qcjA: 31.0	4o0oA-1qcjA: 30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V1F_A_BQ1A1087_0 (F0F1 ATP SYNTHASE SUBUNIT C)	1qcj	POKEWEED ANTIVIRAL PROTEIN (Phytolacca americana)	3 / 3	GLU A 176 ALA A 177 PHE A 180	APT A 901 ( 3.6A) None None	0.66A	4v1fA-1qcjA: undetectable	4v1fA-1qcjA: 14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V1F_C_BQ1C1087_0 (F0F1 ATP SYNTHASE SUBUNIT C)	1qcj	POKEWEED ANTIVIRAL PROTEIN (Phytolacca americana)	3 / 3	GLU A 176 ALA A 177 PHE A 180	APT A 901 ( 3.6A) None None	0.62A	4v1fC-1qcjA: undetectable	4v1fC-1qcjA: 14.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YP2_B_NCAB302_0 (RIBOSOME-INACTIVATIN G PROTEIN MOMORDIN I)	1qcj	POKEWEED ANTIVIRAL PROTEIN (Phytolacca americana)	6 / 9	TYR A 72 PHE A 90 TYR A 123 ILE A 171 GLU A 176 ARG A 179	APT A 901 (-3.9A) APT A 901 ( 4.7A) APT A 901 (-4.7A) APT A 901 (-3.7A) APT A 901 ( 3.6A) APT A 901 (-3.0A)	0.59A	4yp2B-1qcjA: 31.0	4yp2B-1qcjA: 30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5CF9_B_NCAB302_0 (RIBOSOME-INACTIVATIN G PROTEIN MOMORDIN I)	1qcj	POKEWEED ANTIVIRAL PROTEIN (Phytolacca americana)	6 / 9	TYR A 72 PHE A 90 TYR A 123 ILE A 171 GLU A 176 ARG A 179	APT A 901 (-3.9A) APT A 901 ( 4.7A) APT A 901 (-4.7A) APT A 901 (-3.7A) APT A 901 ( 3.6A) APT A 901 (-3.0A)	0.58A	5cf9B-1qcjA: 31.1	5cf9B-1qcjA: 30.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z3J_A_NCAA302_0 (ABRIN A-CHAIN)	1qcj	POKEWEED ANTIVIRAL PROTEIN (Phytolacca americana)	6 / 6	TYR A 72 VAL A 73 TYR A 123 ILE A 171 GLU A 176 ARG A 179	APT A 901 (-3.9A) APT A 901 (-3.4A) APT A 901 (-4.7A) APT A 901 (-3.7A) APT A 901 ( 3.6A) APT A 901 (-3.0A)	0.63A	5z3jA-1qcjA: 32.4	5z3jA-1qcjA: 27.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MRG_A_ADNA300_1","ALPHA-MOMORCHARIN","1qcj","POKEWEED ANTIVIRAL PROTEIN","Phytolacca americana",5,"PHE A  90;TYR A 123;ILE A 171;GLU A 176;ARG A 179","APT A 901 ( 4.7A);APT A 901 (-4.7A);APT A 901 (-3.7A);APT A 901 ( 3.6A);APT A 901 (-3.0A)","0.46A","1mrgA-1qcjA:30.6",null],["1MRJ_A_ADNA300_1","ALPHA-TRICHOSANTHIN","1qcj","POKEWEED ANTIVIRAL PROTEIN","Phytolacca americana",4,"TYR A 123;ILE A 171;GLU A 176;ARG A 179","APT A 901 (-4.7A);APT A 901 (-3.7A);APT A 901 ( 3.6A);APT A 901 (-3.0A)","0.33A","1mrjA-1qcjA:30.4","1mrgA-1qcjA:31.02"],["1MRJ_A_ADNA300_1","ALPHA-TRICHOSANTHIN","1qcj","POKEWEED ANTIVIRAL PROTEIN","Phytolacca americana",4,"TYR A 123;ILE A 171;SER A 175;ARG A 179","APT A 901 (-4.7A);APT A 901 (-3.7A);APT A 901 (-1.7A);APT A 901 (-3.0A)","0.65A","1mrjA-1qcjA:30.4","1mrjA-1qcjA:28.68"],["1T9U_A_CPFA5002_1","ACRIFLAVINE RESISTANCE PROTEIN B","1qcj","POKEWEED ANTIVIRAL PROTEIN","Phytolacca americana",4,"PHE A  90;ASN A  91;ARG A  67;ASN A  70","APT A 901 ( 4.7A);None;None;None","1.37A","1t9uA-1qcjA:0.0","1mrjA-1qcjA:28.68"],["3Q5S_A_ACHA1289_0","MULTIDRUG-EFFLUX TRANSPORTER 1 REGULATOR","1qcj","POKEWEED ANTIVIRAL PROTEIN","Phytolacca americana",4,"ASN A 198;TYR A 123;GLU A 176;ILE A 183","None;APT A 901 (-4.7A);APT A 901 ( 3.6A);None","1.06A","3q5sA-1qcjA:undetectable","1t9uA-1qcjA:12.38"],["3U6T_A_KANA4699_1","RIBOSOME INACTIVATING PROTEIN","1qcj","POKEWEED ANTIVIRAL PROTEIN","Phytolacca americana",5,"TYR A  72;TYR A 123;ILE A 171;GLU A 176;ARG A 179","APT A 901 (-3.9A);APT A 901 (-4.7A);APT A 901 (-3.7A);APT A 901 ( 3.6A);APT A 901 (-3.0A)","0.59A","3u6tA-1qcjA:30.9","3q5sA-1qcjA:22.01"],["4O0O_A_URFA303_1","RRNA N-GLYCOSIDASE","1qcj","POKEWEED ANTIVIRAL PROTEIN","Phytolacca americana",4,"TYR A  72;TYR A 123;ILE A 171;ARG A 179","APT A 901 (-3.9A);APT A 901 (-4.7A);APT A 901 (-3.7A);APT A 901 (-3.0A)","0.37A","4o0oA-1qcjA:31.0","3u6tA-1qcjA:30.42"],["4V1F_A_BQ1A1087_0","F0F1 ATP SYNTHASE SUBUNIT C","1qcj","POKEWEED ANTIVIRAL PROTEIN","Phytolacca americana",3,"GLU A 176;ALA A 177;PHE A 180","APT A 901 ( 3.6A);None;None","0.66A","4v1fA-1qcjA:undetectable","4o0oA-1qcjA:30.42"],["4V1F_C_BQ1C1087_0","F0F1 ATP SYNTHASE SUBUNIT C","1qcj","POKEWEED ANTIVIRAL PROTEIN","Phytolacca americana",3,"GLU A 176;ALA A 177;PHE A 180","APT A 901 ( 3.6A);None;None","0.62A","4v1fC-1qcjA:undetectable","4v1fA-1qcjA:14.62"],["4YP2_B_NCAB302_0","RIBOSOME-INACTIVATING PROTEIN MOMORDIN I","1qcj","POKEWEED ANTIVIRAL PROTEIN","Phytolacca americana",6,"TYR A  72;PHE A  90;TYR A 123;ILE A 171;GLU A 176;ARG A 179","APT A 901 (-3.9A);APT A 901 ( 4.7A);APT A 901 (-4.7A);APT A 901 (-3.7A);APT A 901 ( 3.6A);APT A 901 (-3.0A)","0.59A","4yp2B-1qcjA:31.0","4v1fC-1qcjA:14.62"],["5CF9_B_NCAB302_0","RIBOSOME-INACTIVATING PROTEIN MOMORDIN I","1qcj","POKEWEED ANTIVIRAL PROTEIN","Phytolacca americana",6,"TYR A  72;PHE A  90;TYR A 123;ILE A 171;GLU A 176;ARG A 179","APT A 901 (-3.9A);APT A 901 ( 4.7A);APT A 901 (-4.7A);APT A 901 (-3.7A);APT A 901 ( 3.6A);APT A 901 (-3.0A)","0.58A","5cf9B-1qcjA:31.1","4yp2B-1qcjA:30.80"],["5Z3J_A_NCAA302_0","ABRIN A-CHAIN","1qcj","POKEWEED ANTIVIRAL PROTEIN","Phytolacca americana",6,"TYR A  72;VAL A  73;TYR A 123;ILE A 171;GLU A 176;ARG A 179","APT A 901 (-3.9A);APT A 901 (-3.4A);APT A 901 (-4.7A);APT A 901 (-3.7A);APT A 901 ( 3.6A);APT A 901 (-3.0A)","0.63A","5z3jA-1qcjA:32.4","5cf9B-1qcjA:30.80"]]