SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'APK'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 559
LEU A 581
GLU A 582
LEU A 595
 APK  A 481 ( 3.4A)
None
None
None
 1.06A 1cmaA-1vs0A:
undetectable
1cmaB-1vs0A:
undetectable		 1cmaA-1vs0A:
15.86
1cmaB-1vs0A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 479
GLU A 582
LEU A 581
ALA A 558
PHE A 559
 APK  A 481 ( 4.2A)
None
None
None
APK  A 481 ( 3.4A)
 1.37A 1cmaA-1vs0A:
undetectable
1cmaB-1vs0A:
undetectable		 1cmaA-1vs0A:
15.86
1cmaB-1vs0A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 558
PHE A 559
GLU A 479
GLU A 582
LEU A 581
 None
APK  A 481 ( 3.4A)
APK  A 481 ( 4.2A)
None
None
 1.42A 1cmcA-1vs0A:
undetectable
1cmcB-1vs0A:
undetectable		 1cmcA-1vs0A:
15.86
1cmcB-1vs0A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 486
ASP A 560
ASP A 528
TYR A 624
 APK  A 481 ( 4.0A)
None
None
None
 1.07A 2e5dA-1vs0A:
undetectable
2e5dB-1vs0A:
undetectable		 2e5dA-1vs0A:
19.80
2e5dB-1vs0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		4 / 7 ASP A 528
TYR A 624
ARG A 486
ASP A 560
 None
None
APK  A 481 ( 4.0A)
None
 1.09A 2e5dA-1vs0A:
undetectable
2e5dB-1vs0A:
undetectable		 2e5dA-1vs0A:
19.80
2e5dB-1vs0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 2hvq HYPOTHETICAL 37.6
KDA PROTEIN IN
GP24-HOC INTERGENIC
REGION
(Escherichia
virus
T4) 		5 / 12 ASN A  40
ARG A  55
PHE A 119
VAL A 207
LYS A 225
 APK  A  35 ( 3.7A)
APK  A  35 ( 2.8A)
APK  A  35 ( 3.7A)
APK  A  35 ( 4.1A)
APK  A  35 ( 3.4A)
 0.99A 3qwuA-2hvqA:
11.8		 3qwuA-2hvqA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 2hvq HYPOTHETICAL 37.6
KDA PROTEIN IN
GP24-HOC INTERGENIC
REGION
(Escherichia
virus
T4) 		7 / 12 TYR A   5
ASN A  40
GLU A  99
PHE A 119
VAL A 207
LYS A 209
LYS A 225
 None
APK  A  35 ( 3.7A)
APK  A  35 ( 3.3A)
APK  A  35 ( 3.7A)
APK  A  35 ( 4.1A)
None
APK  A  35 ( 3.4A)
 0.58A 3qwuA-2hvqA:
11.8		 3qwuA-2hvqA:
23.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QWU_A_ADNA501_1
(DNA LIGASE)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		10 / 12 ILE A  74
GLU A  95
ASN A 102
ARG A 118
GLU A 151
PHE A 175
VAL A 203
VAL A 234
LYS A 236
LYS A 246
 APK  A  97 (-4.3A)
APK  A  97 ( 4.2A)
APK  A  97 ( 3.8A)
SO4  A 502 (-3.2A)
APK  A  97 ( 3.0A)
APK  A  97 ( 3.5A)
APK  A  97 ( 4.7A)
APK  A  97 ( 4.3A)
APK  A  97 ( 3.3A)
SO4  A 501 ( 2.7A)
 0.47A 3qwuA-5d1pA:
39.9		 3qwuA-5d1pA:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 2hvq HYPOTHETICAL 37.6
KDA PROTEIN IN
GP24-HOC INTERGENIC
REGION
(Escherichia
virus
T4) 		5 / 11 ASN A  40
ARG A  55
GLU A  99
PHE A 119
VAL A 207
 APK  A  35 ( 3.7A)
APK  A  35 ( 2.8A)
APK  A  35 ( 3.3A)
APK  A  35 ( 3.7A)
APK  A  35 ( 4.1A)
 0.91A 3qwuB-2hvqA:
13.2		 3qwuB-2hvqA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 2hvq HYPOTHETICAL 37.6
KDA PROTEIN IN
GP24-HOC INTERGENIC
REGION
(Escherichia
virus
T4) 		6 / 11 TYR A   5
ASN A  40
GLU A  99
PHE A 119
VAL A 207
LYS A 209
 None
APK  A  35 ( 3.7A)
APK  A  35 ( 3.3A)
APK  A  35 ( 3.7A)
APK  A  35 ( 4.1A)
None
 0.55A 3qwuB-2hvqA:
13.2		 3qwuB-2hvqA:
23.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QWU_B_ADNB501_1
(DNA LIGASE)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		9 / 11 ILE A  74
GLU A  95
ASN A 102
ARG A 118
GLU A 151
PHE A 175
VAL A 203
VAL A 234
LYS A 236
 APK  A  97 (-4.3A)
APK  A  97 ( 4.2A)
APK  A  97 ( 3.8A)
SO4  A 502 (-3.2A)
APK  A  97 ( 3.0A)
APK  A  97 ( 3.5A)
APK  A  97 ( 4.7A)
APK  A  97 ( 4.3A)
APK  A  97 ( 3.3A)
 0.39A 3qwuB-5d1pA:
40.0		 3qwuB-5d1pA:
30.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 6 GLU A 151
ILE A 153
ASN A 157
GLU A 132
 APK  A  97 ( 3.0A)
None
None
None
 1.12A 4ejwB-5d1pA:
undetectable		 4ejwB-5d1pA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 486
ASP A 560
SER A 622
TYR A 624
 APK  A 481 ( 4.0A)
None
None
None
 0.99A 4lv9A-1vs0A:
undetectable
4lv9B-1vs0A:
undetectable		 4lv9A-1vs0A:
19.49
4lv9B-1vs0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 MET A 235
MET A  98
TYR A 247
 None
APK  A  97 ( 4.2A)
None
 1.24A 4p6xI-5d1pA:
undetectable		 4p6xI-5d1pA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 2hvq HYPOTHETICAL 37.6
KDA PROTEIN IN
GP24-HOC INTERGENIC
REGION
(Escherichia
virus
T4) 		4 / 5 GLY A  38
THR A  39
GLY A 102
GLU A  99
 None
None
None
APK  A  35 ( 3.3A)
 1.17A 4v20A-2hvqA:
undetectable		 4v20A-2hvqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.28A 5ad6A-5d1pA:
undetectable
5ad6B-5d1pA:
undetectable		 5ad6A-5d1pA:
23.79
5ad6B-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 574
LYS A 618
GLY A 480
LEU A 595
 None
APK  A 481 ( 2.9A)
APK  A 481 ( 2.5A)
None
 0.86A 5bphB-1vs0A:
undetectable		 5bphB-1vs0A:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 592
PHE A 559
CYH A 606
LEU A 595
ALA A 473
 None
APK  A 481 ( 3.4A)
None
None
None
 1.50A 5fctB-1vs0A:
0.0		 5fctB-1vs0A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.26A 5fw0A-5d1pA:
undetectable
5fw0B-5d1pA:
undetectable		 5fw0A-5d1pA:
23.79
5fw0B-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.27A 5unuA-5d1pA:
undetectable
5unuB-5d1pA:
undetectable		 5unuA-5d1pA:
23.79
5unuB-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.20A 5unwA-5d1pA:
undetectable
5unwB-5d1pA:
undetectable		 5unwA-5d1pA:
23.79
5unwB-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 MET A  98
ARG A 192
VAL A 234
GLU A 151
 APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
APK  A  97 ( 3.0A)
 1.33A 5unxA-5d1pA:
2.1
5unxB-5d1pA:
undetectable		 5unxA-5d1pA:
23.79
5unxB-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.22A 5uo0A-5d1pA:
2.1
5uo0B-5d1pA:
undetectable		 5uo0A-5d1pA:
23.79
5uo0B-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.23A 5uo3A-5d1pA:
undetectable
5uo3B-5d1pA:
undetectable		 5uo3A-5d1pA:
23.21
5uo3B-5d1pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.25A 5uo6A-5d1pA:
undetectable
5uo6B-5d1pA:
undetectable		 5uo6A-5d1pA:
23.21
5uo6B-5d1pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 MET A  98
ARG A 192
VAL A 234
GLU A 151
 APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
APK  A  97 ( 3.0A)
 1.23A 5uo7A-5d1pA:
undetectable
5uo7B-5d1pA:
undetectable		 5uo7A-5d1pA:
23.21
5uo7B-5d1pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.24A 5uo7A-5d1pA:
undetectable
5uo7B-5d1pA:
undetectable		 5uo7A-5d1pA:
23.21
5uo7B-5d1pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.26A 5vuiA-5d1pA:
undetectable
5vuiB-5d1pA:
undetectable		 5vuiA-5d1pA:
23.79
5vuiB-5d1pA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d1p ATP-DEPENDENT RNA
LIGASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 GLU A 151
MET A  98
ARG A 192
VAL A 234
 APK  A  97 ( 3.0A)
APK  A  97 ( 4.2A)
None
APK  A  97 ( 4.3A)
 1.23A 5vv3A-5d1pA:
undetectable
5vv3B-5d1pA:
undetectable		 5vv3A-5d1pA:
23.21
5vv3B-5d1pA:
23.21