SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'API'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN
(Helicobacter
pylori) 		5 / 11 ILE A  45
GLU A 222
GLY A  52
HIS A 236
GLY A  44
 None
API  A 510 (-3.6A)
None
None
None
 1.45A 2fn1B-4q6pA:
undetectable		 2fn1B-4q6pA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5lkw PUTATIVE OMPA FAMILY
LIPOPROTEIN
(Burkholderia
cenocepacia) 		4 / 8 GLY A 108
ASN A 113
PHE A  70
TYR A 112
 API  A 201 ( 4.5A)
API  A 201 (-3.3A)
API  A 201 (-4.5A)
None
 1.29A 3ccfA-5lkwA:
undetectable		 3ccfA-5lkwA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4g88 OUTER MEMBRANE
PROTEIN OMP38
(Acinetobacter
baumannii) 		3 / 3 ARG A 330
ARG A 286
ILE A 316
 None
API  A 401 (-3.0A)
None
 0.83A 4b7qA-4g88A:
undetectable		 4b7qA-4g88A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 4g88 OUTER MEMBRANE
PROTEIN OMP38
(Acinetobacter
baumannii) 		3 / 3 ARG A 330
ARG A 286
ILE A 316
 None
API  A 401 (-3.0A)
None
 0.89A 4b7qC-4g88A:
undetectable		 4b7qC-4g88A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 6 ARG A 443
GLY A 442
ASP A 413
PRO A 415
 None
None
API  A1499 (-3.6A)
None
 1.05A 4lajA-1e8cA:
0.0
4lajB-1e8cA:
0.0		 4lajA-1e8cA:
19.85
4lajB-1e8cA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 5 THR A 122
THR A 123
HIS A 359
ASN A 205
 None
None
API  A1499 (-3.7A)
None
 1.28A 4pgfB-1e8cA:
2.6		 4pgfB-1e8cA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		4 / 7 GLU A 468
THR A 142
THR A 157
HIS A 359
 API  A1499 (-3.1A)
None
UAG  A1498 (-3.9A)
API  A1499 (-3.7A)
 0.91A 4qwpB-1e8cA:
undetectable		 4qwpB-1e8cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE
(Escherichia
coli) 		3 / 3 GLU A 468
HIS A 467
ARG A 483
 API  A1499 (-3.1A)
None
None
 0.99A 5uunA-1e8cA:
0.5		 5uunA-1e8cA:
19.55