SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AP2'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
3 / 3 LEU A 710
SER A 700
ASN A 733
None
None
AP2  A 806 (-4.9A)
0.50A 1bx4A-3vthA:
undetectable
1bx4A-3vthA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
5 / 9 GLY A 407
GLY A 735
GLY A 701
GLY A 702
ASP A 507
None
None
AP2  A 806 ( 4.3A)
AP2  A 806 (-3.3A)
FE  A 807 ( 3.1A)
0.94A 1mxdA-3vthA:
undetectable
1mxdA-3vthA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
5 / 11 GLY A 407
GLY A 735
GLY A 701
GLY A 702
ASP A 507
None
None
AP2  A 806 ( 4.3A)
AP2  A 806 (-3.3A)
FE  A 807 ( 3.1A)
0.97A 1mxgA-3vthA:
1.9
1mxgA-3vthA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
3fd5 SELENIDE, WATER
DIKINASE 1

(Homo
sapiens)
4 / 7 SER A 109
LEU A 325
HIS A 274
THR A 267
None
None
AP2  A 393 ( 4.3A)
PO4  A 394 ( 3.3A)
1.13A 2f78B-3fd5A:
undetectable
2f78B-3fd5A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
4 / 6 VAL A 517
ASP A 460
HIS A 483
TYR A 409
None
None
FE  A 807 ( 3.4A)
AP2  A 806 (-4.2A)
1.23A 2zs9A-3vthA:
undetectable
2zs9A-3vthA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
4 / 8 ILE A 737
HIS A 487
TYR A 465
GLY A 510
None
FE  A 807 ( 3.4A)
None
AP2  A 806 ( 4.8A)
0.93A 3b9lA-3vthA:
undetectable
3b9lA-3vthA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
4 / 5 ILE A 737
HIS A 487
TYR A 465
GLY A 510
None
FE  A 807 ( 3.4A)
None
AP2  A 806 ( 4.8A)
1.05A 3b9mA-3vthA:
undetectable
3b9mA-3vthA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
6 / 11 TYR A 511
GLY A 510
ASP A 460
GLY A 701
ALA A 486
ALA A 489
None
AP2  A 806 ( 4.8A)
None
AP2  A 806 ( 4.3A)
None
None
1.41A 3sufC-3vthA:
undetectable
3sufC-3vthA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
5 / 11 GLY A 598
ASP A 507
GLY A 508
VAL A 594
HIS A 484
AP2  A 806 (-3.2A)
FE  A 807 ( 3.1A)
AP2  A 806 (-3.0A)
None
None
1.37A 4c5lA-3vthA:
3.0
4c5lA-3vthA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
5 / 10 GLY A 598
ASP A 507
GLY A 508
VAL A 594
HIS A 484
AP2  A 806 (-3.2A)
FE  A 807 ( 3.1A)
AP2  A 806 (-3.0A)
None
None
1.40A 4c5lD-3vthA:
undetectable
4c5lD-3vthA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
5 / 10 GLY A 598
ASP A 507
GLY A 508
VAL A 594
HIS A 484
AP2  A 806 (-3.2A)
FE  A 807 ( 3.1A)
AP2  A 806 (-3.0A)
None
None
1.29A 4c5nD-3vthA:
undetectable
4c5nD-3vthA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)
2vqd BIOTIN CARBOXYLASE
(Pseudomonas
aeruginosa)
4 / 5 HIS A 209
VAL A 210
GLU A 211
LYS A 238
AP2  A1448 (-3.7A)
None
None
None
1.22A 4p6vB-2vqdA:
undetectable
4p6vE-2vqdA:
undetectable
4p6vB-2vqdA:
21.44
4p6vE-2vqdA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
5 / 12 VAL A 604
LEU A 709
PHE A 704
PHE A 601
GLY A 598
None
None
None
AP2  A 806 (-3.7A)
AP2  A 806 (-3.2A)
1.33A 4pevC-3vthA:
undetectable
4pevC-3vthA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
4 / 6 TYR A 708
ASN A 706
LEU A 624
PHE A 673
None
AP2  A 806 (-3.7A)
None
None
0.92A 4twdB-3vthA:
undetectable
4twdC-3vthA:
undetectable
4twdB-3vthA:
17.11
4twdC-3vthA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
4 / 6 TYR A 708
ASN A 706
LEU A 624
PHE A 673
None
AP2  A 806 (-3.7A)
None
None
0.96A 4twdD-3vthA:
undetectable
4twdE-3vthA:
undetectable
4twdD-3vthA:
17.11
4twdE-3vthA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
4 / 6 TYR A 708
ASN A 706
LEU A 624
PHE A 673
None
AP2  A 806 (-3.7A)
None
None
0.85A 4twdI-3vthA:
undetectable
4twdJ-3vthA:
undetectable
4twdI-3vthA:
17.11
4twdJ-3vthA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
5 / 12 GLY A 736
ASN A 411
GLY A 701
SER A 700
GLY A 406
None
None
AP2  A 806 ( 4.3A)
None
None
1.26A 5hikA-3vthA:
undetectable
5hikA-3vthA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
5 / 12 SER A 596
VAL A 517
GLY A 510
GLY A 508
TYR A 409
None
None
AP2  A 806 ( 4.8A)
AP2  A 806 (-3.0A)
AP2  A 806 (-4.2A)
1.15A 5nnaA-3vthA:
undetectable
5nnaA-3vthA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
5 / 12 SER A 596
VAL A 517
GLY A 510
GLY A 508
TYR A 409
None
None
AP2  A 806 ( 4.8A)
AP2  A 806 (-3.0A)
AP2  A 806 (-4.2A)
1.13A 5nnaB-3vthA:
undetectable
5nnaB-3vthA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
5 / 12 SER A 596
VAL A 517
GLY A 510
GLY A 508
TYR A 409
None
None
AP2  A 806 ( 4.8A)
AP2  A 806 (-3.0A)
AP2  A 806 (-4.2A)
1.12A 5nnaC-3vthA:
undetectable
5nnaC-3vthA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
5 / 12 SER A 596
VAL A 517
GLY A 510
GLY A 508
TYR A 409
None
None
AP2  A 806 ( 4.8A)
AP2  A 806 (-3.0A)
AP2  A 806 (-4.2A)
1.17A 5nnaD-3vthA:
undetectable
5nnaD-3vthA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus)
5 / 9 VAL A 594
LEU A 556
ARG A 599
ALA A 555
ASP A 602
None
None
AP2  A 806 (-4.1A)
None
None
1.20A 6c2mB-3vthA:
undetectable
6c2mB-3vthA:
7.23