SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AP2'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1BX4_A_ADNA350_2 (PROTEIN (ADENOSINEKINASE)) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 3 / 3 | LEU A 710SER A 700ASN A 733 | NoneNoneAP2 A 806 (-4.9A) | 0.50A | 1bx4A-3vthA:undetectable | 1bx4A-3vthA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MXD_A_ACRA732_1 (ALPHA AMYLASE) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 5 / 9 | GLY A 407GLY A 735GLY A 701GLY A 702ASP A 507 | NoneNoneAP2 A 806 ( 4.3A)AP2 A 806 (-3.3A) FE A 807 ( 3.1A) | 0.94A | 1mxdA-3vthA:undetectable | 1mxdA-3vthA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1MXG_A_ACRA442_1 (ALPHA AMYLASE) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 5 / 11 | GLY A 407GLY A 735GLY A 701GLY A 702ASP A 507 | NoneNoneAP2 A 806 ( 4.3A)AP2 A 806 (-3.3A) FE A 807 ( 3.1A) | 0.97A | 1mxgA-3vthA:1.9 | 1mxgA-3vthA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2F78_B_BEZB1004_0 (HTH-TYPETRANSCRIPTIONALREGULATOR BENM) |
3fd5 | SELENIDE, WATERDIKINASE 1 (Homosapiens) | 4 / 7 | SER A 109LEU A 325HIS A 274THR A 267 | NoneNoneAP2 A 393 ( 4.3A)PO4 A 394 ( 3.3A) | 1.13A | 2f78B-3fd5A:undetectable | 2f78B-3fd5A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ZS9_A_PAUA603_0 (PANTOTHENATE KINASE) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 4 / 6 | VAL A 517ASP A 460HIS A 483TYR A 409 | NoneNone FE A 807 ( 3.4A)AP2 A 806 (-4.2A) | 1.23A | 2zs9A-3vthA:undetectable | 2zs9A-3vthA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3B9L_A_AZZA1010_1 (SERUM ALBUMIN) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 4 / 8 | ILE A 737HIS A 487TYR A 465GLY A 510 | None FE A 807 ( 3.4A)NoneAP2 A 806 ( 4.8A) | 0.93A | 3b9lA-3vthA:undetectable | 3b9lA-3vthA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3B9M_A_SALA1200_1 (SERUM ALBUMIN) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 4 / 5 | ILE A 737HIS A 487TYR A 465GLY A 510 | None FE A 807 ( 3.4A)NoneAP2 A 806 ( 4.8A) | 1.05A | 3b9mA-3vthA:undetectable | 3b9mA-3vthA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3SUF_C_SUEC1201_1 (NS3 PROTEASE, NS4APROTEIN) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 6 / 11 | TYR A 511GLY A 510ASP A 460GLY A 701ALA A 486ALA A 489 | NoneAP2 A 806 ( 4.8A)NoneAP2 A 806 ( 4.3A)NoneNone | 1.41A | 3sufC-3vthA:undetectable | 3sufC-3vthA:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4C5L_A_UEGA300_1 (PHOSPHOMETHYLPYRIMIDINE KINASE) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 5 / 11 | GLY A 598ASP A 507GLY A 508VAL A 594HIS A 484 | AP2 A 806 (-3.2A) FE A 807 ( 3.1A)AP2 A 806 (-3.0A)NoneNone | 1.37A | 4c5lA-3vthA:3.0 | 4c5lA-3vthA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4C5L_D_UEGD300_1 (PHOSPHOMETHYLPYRIMIDINE KINASE) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 5 / 10 | GLY A 598ASP A 507GLY A 508VAL A 594HIS A 484 | AP2 A 806 (-3.2A) FE A 807 ( 3.1A)AP2 A 806 (-3.0A)NoneNone | 1.40A | 4c5lD-3vthA:undetectable | 4c5lD-3vthA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4C5N_D_UEGD300_1 (PHOSPHOMETHYLPYRIMIDINE KINASE) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 5 / 10 | GLY A 598ASP A 507GLY A 508VAL A 594HIS A 484 | AP2 A 806 (-3.2A) FE A 807 ( 3.1A)AP2 A 806 (-3.0A)NoneNone | 1.29A | 4c5nD-3vthA:undetectable | 4c5nD-3vthA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4P6V_E_RBFE201_1 (NA(+)-TRANSLOCATINGNADH-QUINONEREDUCTASE SUBUNIT BNA(+)-TRANSLOCATINGNADH-QUINONEREDUCTASE SUBUNIT E) |
2vqd | BIOTIN CARBOXYLASE (Pseudomonasaeruginosa) | 4 / 5 | HIS A 209VAL A 210GLU A 211LYS A 238 | AP2 A1448 (-3.7A)NoneNoneNone | 1.22A | 4p6vB-2vqdA:undetectable4p6vE-2vqdA:undetectable | 4p6vB-2vqdA:21.444p6vE-2vqdA:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PEV_C_ADNC501_1 (MEMBRANE LIPOPROTEINFAMILY PROTEIN) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 5 / 12 | VAL A 604LEU A 709PHE A 704PHE A 601GLY A 598 | NoneNoneNoneAP2 A 806 (-3.7A)AP2 A 806 (-3.2A) | 1.33A | 4pevC-3vthA:undetectable | 4pevC-3vthA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TWD_C_377C401_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 4 / 6 | TYR A 708ASN A 706LEU A 624PHE A 673 | NoneAP2 A 806 (-3.7A)NoneNone | 0.92A | 4twdB-3vthA:undetectable4twdC-3vthA:undetectable | 4twdB-3vthA:17.114twdC-3vthA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TWD_E_377E401_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 4 / 6 | TYR A 708ASN A 706LEU A 624PHE A 673 | NoneAP2 A 806 (-3.7A)NoneNone | 0.96A | 4twdD-3vthA:undetectable4twdE-3vthA:undetectable | 4twdD-3vthA:17.114twdE-3vthA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4TWD_J_377J401_1 (CYS-LOOPLIGAND-GATED IONCHANNEL) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 4 / 6 | TYR A 708ASN A 706LEU A 624PHE A 673 | NoneAP2 A 806 (-3.7A)NoneNone | 0.85A | 4twdI-3vthA:undetectable4twdJ-3vthA:undetectable | 4twdI-3vthA:17.114twdJ-3vthA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5HIK_A_SAMA301_0 (GLYCINE SARCOSINEN-METHYLTRANSFERASE) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 5 / 12 | GLY A 736ASN A 411GLY A 701SER A 700GLY A 406 | NoneNoneAP2 A 806 ( 4.3A)NoneNone | 1.26A | 5hikA-3vthA:undetectable | 5hikA-3vthA:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NNA_A_BZMA301_0 (ISATIN HYDROLASE A) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 5 / 12 | SER A 596VAL A 517GLY A 510GLY A 508TYR A 409 | NoneNoneAP2 A 806 ( 4.8A)AP2 A 806 (-3.0A)AP2 A 806 (-4.2A) | 1.15A | 5nnaA-3vthA:undetectable | 5nnaA-3vthA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NNA_B_BZMB301_0 (ISATIN HYDROLASE A) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 5 / 12 | SER A 596VAL A 517GLY A 510GLY A 508TYR A 409 | NoneNoneAP2 A 806 ( 4.8A)AP2 A 806 (-3.0A)AP2 A 806 (-4.2A) | 1.13A | 5nnaB-3vthA:undetectable | 5nnaB-3vthA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NNA_C_BZMC301_0 (ISATIN HYDROLASE A) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 5 / 12 | SER A 596VAL A 517GLY A 510GLY A 508TYR A 409 | NoneNoneAP2 A 806 ( 4.8A)AP2 A 806 (-3.0A)AP2 A 806 (-4.2A) | 1.12A | 5nnaC-3vthA:undetectable | 5nnaC-3vthA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5NNA_D_BZMD301_0 (ISATIN HYDROLASE A) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 5 / 12 | SER A 596VAL A 517GLY A 510GLY A 508TYR A 409 | NoneNoneAP2 A 806 ( 4.8A)AP2 A 806 (-3.0A)AP2 A 806 (-4.2A) | 1.17A | 5nnaD-3vthA:undetectable | 5nnaD-3vthA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6C2M_B_SUEB1202_1 (NS3 PROTEASE) |
3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) | 5 / 9 | VAL A 594LEU A 556ARG A 599ALA A 555ASP A 602 | NoneNoneAP2 A 806 (-4.1A)NoneNone | 1.20A | 6c2mB-3vthA:undetectable | 6c2mB-3vthA:7.23 |