SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AOV'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 GLN A 610
TYR A  55
ARG A  56
 None
AOV  A1001 ( 4.5A)
None
 0.76A 1gtbA-4byfA:
undetectable		 1gtbA-4byfA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		4 / 6 PRO A1687
ASP A1741
ASN A2067
ASP A2071
 None
MG  A4402 ( 2.3A)
AOV  A4401 ( 4.8A)
AOV  A4401 ( 3.1A)
 1.29A 1hpkA-4rh7A:
undetectable		 1hpkA-4rh7A:
2.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct) 		5 / 12 CYH A1715
THR A1790
GLY A1738
ILE A1727
PHE A1728
 None
AOV  A4401 ( 4.6A)
None
None
None
 1.35A 1oltA-4rh7A:
undetectable		 1oltA-4rh7A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		5 / 12 SER A 160
GLY A 164
GLY A 150
LEU A 186
LEU A 410
 AOV  A1001 (-3.0A)
None
None
None
None
 1.02A 2nyuB-4byfA:
undetectable		 2nyuB-4byfA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		3 / 3 TYR A 148
TYR A 129
ILE A 145
 AOV  A1500 (-4.4A)
None
None
 0.76A 3eteA-5i4eA:
undetectable
3eteB-5i4eA:
0.8		 3eteA-5i4eA:
19.17
3eteB-5i4eA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 6 GLU A 206
ASP A 478
ASP A 257
ASN A 250
 AOV  A1500 (-4.2A)
MG  A1501 ( 4.6A)
None
None
 1.24A 3vywA-5i4eA:
undetectable		 3vywA-5i4eA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Homo
sapiens;
Dictyostelium
discoideum) 		4 / 5 GLU A 206
ASP A 478
ASP A 257
ASN A 250
 AOV  A1500 (-4.2A)
MG  A1501 ( 4.6A)
None
None
 1.24A 3vywD-5i4eA:
undetectable		 3vywD-5i4eA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		3 / 3 PRO A 593
TYR A  55
GLY A 600
 None
AOV  A1001 ( 4.5A)
None
 0.66A 4g2zA-4byfA:
undetectable		 4g2zA-4byfA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 7 ASP A 386
ILE A 387
GLY A 389
THR A 112
 MG  A1000 ( 4.0A)
None
AOV  A1001 (-3.1A)
MG  A1000 ( 2.6A)
 0.92A 4zxiA-4byfA:
undetectable		 4zxiA-4byfA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens) 		4 / 6 SER A 242
ARG A 156
GLY A 108
GLU A 106
 None
None
AOV  A1001 (-3.0A)
None
 1.02A 5cdqA-4byfA:
2.8
5cdqC-4byfA:
2.8
5cdqD-4byfA:
undetectable		 5cdqA-4byfA:
22.12
5cdqC-4byfA:
22.12
5cdqD-4byfA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens) 		5 / 12 PHE A 485
TYR A 599
ILE A 479
GLY A 481
ILE A 495
 None
None
None
AOV  A1500 (-3.0A)
None
 1.18A 5ifuA-5i4eA:
undetectable		 5ifuA-5i4eA:
19.11