SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AOQ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		5 / 10 ILE C 281
ALA C 280
TYR C 359
ILE C 125
ILE C 299
 None
None
None
AOQ  C4003 ( 4.4A)
AOQ  C4003 (-4.6A)
 0.96A 2dm6A-4pd4C:
undetectable
2dm6B-4pd4C:
undetectable		 2dm6A-4pd4C:
21.78
2dm6B-4pd4C:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 125
ILE C 299
PHE C 296
ALA C 298
ALA C 280
 AOQ  C4003 ( 4.4A)
AOQ  C4003 (-4.6A)
None
None
None
 1.17A 2j0dA-4pd4C:
1.8		 2j0dA-4pd4C:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 125
LEU C 275
ILE C 122
PHE C 121
PHE C 333
 AOQ  C4003 ( 4.4A)
AOQ  C4003 (-3.8A)
None
3PH  C4006 ( 4.6A)
3PH  C4006 (-4.1A)
 1.01A 2ygqA-4pd4C:
undetectable		 2ygqA-4pd4C:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 7 PHE C 329
TYR C 359
PRO C 277
PHE C 278
 3PH  C4006 ( 4.9A)
None
None
AOQ  C4003 ( 4.6A)
 1.35A 4grqA-4pd4C:
undetectable
4grqC-4pd4C:
undetectable		 4grqA-4pd4C:
13.81
4grqC-4pd4C:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 5 ILE C 147
PHE C 129
ASN C  57
TYR C 136
 AOQ  C4003 (-4.8A)
AOQ  C4003 (-4.6A)
None
None
 1.20A 6a93B-4pd4C:
5.1		 6a93B-4pd4C:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4pd4 CYTOCHROME B
(Saccharomyces
cerevisiae) 		4 / 6 LEU C 275
TYR C 274
VAL C 194
PHE C 129
 AOQ  C4003 (-3.8A)
None
HEM  C4002 (-4.4A)
AOQ  C4003 (-4.6A)
 0.88A 6hd4B-4pd4C:
undetectable		 6hd4B-4pd4C:
11.97