SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AOO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 238
HIS A 274
THR A 325
HIS A  63
 ZN  A 458 (-3.2A)
AOO  A 457 ( 4.6A)
AOO  A 457 (-4.0A)
ZN  A 458 (-3.3A)
 0.85A 1bzmA-3lscA:
undetectable		 1bzmA-3lscA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 TYR A  67
ALA A 328
GLY A  69
GLY A 326
TRP A  85
 AOO  A 457 (-4.7A)
None
None
None
None
 1.15A 3ou6B-3lscA:
undetectable		 3ou6B-3lscA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 TYR A  67
ALA A 328
GLY A  69
GLY A 326
TRP A  85
 AOO  A 457 (-4.7A)
None
None
None
None
 1.16A 3ou7A-3lscA:
undetectable		 3ou7A-3lscA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 TYR A  67
ALA A 328
GLY A  69
GLY A 326
TRP A  85
 AOO  A 457 (-4.7A)
None
None
None
None
 1.18A 3ou7D-3lscA:
undetectable		 3ou7D-3lscA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 ASP A 244
HIS A 238
HIS A  65
LEU A  86
TRP A  85
 None
ZN  A 458 (-3.2A)
ZN  A 458 ( 3.2A)
AOO  A 457 ( 4.5A)
None
 1.42A 4yhaA-3lscA:
undetectable		 4yhaA-3lscA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 5 PRO A 299
HIS A 236
LEU A 115
TYR A  67
 None
None
None
AOO  A 457 (-4.7A)
 1.46A 5igjA-3lscA:
undetectable		 5igjA-3lscA:
23.33