SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AOJ'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5whr INDOLEAMINE
2,3-DIOXYGENASE 1
(Homo
sapiens) 		5 / 12 LEU A 388
SER A 263
VAL A 391
LEU A 292
HIS A 287
 HEM  A 501 ( 4.8A)
AOJ  A 502 (-4.1A)
HEM  A 501 (-4.7A)
None
None
 1.29A 1ie9A-5whrA:
undetectable		 1ie9A-5whrA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5whr INDOLEAMINE
2,3-DIOXYGENASE 1
(Homo
sapiens) 		5 / 12 THR A 382
THR A 379
GLY A 265
GLY A 261
ASP A 274
 HEM  A 501 (-2.9A)
AOJ  A 502 ( 2.9A)
HEM  A 501 ( 3.7A)
None
None
 0.95A 2b25A-5whrA:
undetectable		 2b25A-5whrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5whr INDOLEAMINE
2,3-DIOXYGENASE 1
(Homo
sapiens) 		5 / 12 ALA A 338
PHE A 226
PHE A 214
GLY A 378
LEU A 388
 None
HEM  A 501 ( 4.0A)
HEM  A 501 (-4.0A)
AOJ  A 502 (-3.3A)
HEM  A 501 ( 4.8A)
 1.20A 5fsaA-5whrA:
0.9		 5fsaA-5whrA:
10.96