SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ANW'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		4 / 7 VAL A 248
MET A 267
ARG A 313
LEU A 321
 None
None
None
ANW  A 601 (-4.9A)
 0.75A 1iepB-4wboA:
22.0		 1iepB-4wboA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
ALA A 214
LYS A 216
GLU A 235
LEU A 262
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.64A 1m17A-4wboA:
25.9		 1m17A-4wboA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 12 LEU A 193
VAL A 201
ALA A 214
GLU A 235
VAL A 248
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-4.9A)
 0.76A 1opjA-4wboA:
21.6		 1opjA-4wboA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		9 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 239
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.85A 1t46A-4wboA:
22.4		 1t46A-4wboA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		9 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 239
VAL A 248
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
None
ANW  A 601 (-4.9A)
None
 0.96A 1t46A-4wboA:
22.4		 1t46A-4wboA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 9 LEU A 193
VAL A 201
ALA A 214
MET A 264
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.56A 1xbbA-4wboA:
26.3		 1xbbA-4wboA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 9 LEU A 193
VAL A 201
LYS A 216
LEU A 250
LEU A 262
MET A 267
 ANW  A 601 ( 4.0A)
None
None
None
None
None
 0.65A 1xkkA-4wboA:
21.7		 1xkkA-4wboA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 VAL A 201
LYS A 216
VAL A 248
ASP A 271
ASN A 319
LEU A 321
ASP A 332
 None
None
None
None
None
ANW  A 601 (-4.9A)
None
 0.89A 2eufB-4wboA:
27.2		 2eufB-4wboA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
VAL A 201
ALA A 214
MET A 264
LYS A 316
ASN A 319
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
None
None
 0.87A 2fumB-4wboA:
26.9		 2fumB-4wboA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
ALA A 214
LYS A 216
GLU A 235
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.83A 2gqgA-4wboA:
25.4		 2gqgA-4wboA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
ALA A 214
LYS A 216
GLU A 235
LEU A 262
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.68A 2itoA-4wboA:
24.3		 2itoA-4wboA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		9 / 12 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
GLU A 235
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.76A 2ityA-4wboA:
23.6		 2ityA-4wboA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 262
ASP A 332
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
None
None
 0.76A 2ityA-4wboA:
23.6		 2ityA-4wboA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.71A 2itzA-4wboA:
24.0		 2itzA-4wboA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 12 LEU A 193
GLY A 194
LYS A 216
LEU A 239
LEU A 262
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
None
None
ANW  A 601 (-4.9A)
 0.52A 2ivuA-4wboA:
25.9		 2ivuA-4wboA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 12 LEU A 193
GLY A 194
VAL A 201
LYS A 216
LEU A 239
LEU A 262
 ANW  A 601 ( 4.0A)
None
None
None
None
None
 0.36A 2ivuA-4wboA:
25.9		 2ivuA-4wboA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 12 GLY A 194
VAL A 201
ALA A 214
MET A 267
GLY A 270
ASP A 332
 None
None
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
None
 0.61A 2wgjA-4wboA:
18.8		 2wgjA-4wboA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 9 LEU A 193
VAL A 201
ALA A 214
MET A 267
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.57A 2xp2A-4wboA:
23.5		 2xp2A-4wboA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
ALA A 214
LYS A 216
GLU A 235
VAL A 248
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.79A 2zvaA-4wboA:
25.8		 2zvaA-4wboA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 10 ARG A 191
LEU A 193
ALA A 214
LYS A 216
VAL A 248
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.9A)
ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.78A 3aoxA-4wboA:
22.8		 3aoxA-4wboA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
GLY A 194
ALA A 214
LYS A 216
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.55A 3c7qA-4wboA:
22.1		 3c7qA-4wboA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 9 LEU A 193
VAL A 201
LYS A 216
VAL A 248
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
None
ANW  A 601 (-4.9A)
 0.81A 3cs9B-4wboA:
22.1		 3cs9B-4wboA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		4 / 6 LEU A 193
VAL A 201
LYS A 216
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-4.9A)
 0.77A 3cs9D-4wboA:
20.9		 3cs9D-4wboA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
GLY A 194
GLY A 196
VAL A 201
ALA A 214
LYS A 216
MET A 264
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
None
ANW  A 601 (-3.4A)
None
ANW  A 601 (-3.2A)
ANW  A 601 (-4.9A)
 0.71A 3fupB-4wboA:
24.9		 3fupB-4wboA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
VAL A 248
MET A 264
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-3.2A)
ANW  A 601 (-4.9A)
 0.72A 3fupB-4wboA:
24.9		 3fupB-4wboA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 11 LEU A 193
VAL A 201
ALA A 214
GLY A 270
ASP A 271
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
ANW  A 601 ( 4.5A)
None
ANW  A 601 (-4.9A)
 0.55A 3g0fA-4wboA:
22.6		 3g0fA-4wboA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.79A 3g5dB-4wboA:
23.7		 3g5dB-4wboA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
ALA A 214
LYS A 216
GLU A 235
VAL A 248
GLY A 270
LEU A 321
SER A 331
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
ANW  A 601 ( 4.0A)
 0.82A 3k54A-4wboA:
23.1		 3k54A-4wboA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 8 ALA A 214
LYS A 216
GLU A 235
LEU A 262
MET A 267
 ANW  A 601 (-3.4A)
None
None
None
None
 0.72A 3lfaA-4wboA:
19.1		 3lfaA-4wboA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
VAL A 248
MET A 264
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-3.2A)
 0.76A 3lxkA-4wboA:
20.7		 3lxkA-4wboA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.73A 3octA-4wboA:
7.9		 3octA-4wboA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 12 LEU A 193
VAL A 201
ALA A 214
GLU A 235
VAL A 248
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-4.9A)
 0.76A 3pyyB-4wboA:
21.7		 3pyyB-4wboA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.79A 3qlgA-4wboA:
23.5		 3qlgA-4wboA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
ALA A 214
LYS A 216
VAL A 248
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.72A 3ue4A-4wboA:
25.4		 3ue4A-4wboA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		9 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
LEU A 262
MET A 264
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-3.2A)
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.76A 3ug2A-4wboA:
24.7		 3ug2A-4wboA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 12 LEU A 193
VAL A 201
ALA A 214
LEU A 239
GLY A 270
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
 0.47A 3wzdA-4wboA:
22.3		 3wzdA-4wboA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 5 LYS A 216
ILE A 238
VAL A 248
LEU A 321
ASP A 332
 None
None
None
ANW  A 601 (-4.9A)
None
 1.26A 3wzdA-4wboA:
22.3		 3wzdA-4wboA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
LEU A 239
GLY A 270
LEU A 305
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
None
 0.68A 3wzeA-4wboA:
22.4		 3wzeA-4wboA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
ALA A 214
MET A 267
GLY A 270
ASP A 271
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
None
ANW  A 601 (-4.9A)
None
 0.79A 3zbfA-4wboA:
24.4		 3zbfA-4wboA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 9 LEU A 193
ILE A 238
ILE A 247
MET A 267
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
None
 1.01A 3zosB-4wboA:
21.9		 3zosB-4wboA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.87A 4ag8A-4wboA:
22.4		 4ag8A-4wboA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
LEU A 239
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.62A 4agcA-4wboA:
22.0		 4agcA-4wboA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 11 LEU A 193
ALA A 214
LYS A 216
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.76A 4agdA-4wboA:
16.8		 4agdA-4wboA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 9 LEU A 193
VAL A 201
ALA A 214
MET A 267
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.59A 4anqA-4wboA:
23.3		 4anqA-4wboA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 9 LEU A 193
VAL A 201
ALA A 214
MET A 264
MET A 267
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.65A 4ansA-4wboA:
23.3		 4ansA-4wboA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 239
GLY A 270
LEU A 305
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
None
 0.91A 4asdA-4wboA:
22.2		 4asdA-4wboA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.76A 4hjoA-4wboA:
21.9		 4hjoA-4wboA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		9 / 12 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
LEU A 262
MET A 264
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-3.2A)
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.74A 4i22A-4wboA:
21.3		 4i22A-4wboA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		9 / 12 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
MET A 264
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
ANW  A 601 (-3.2A)
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.90A 4i22A-4wboA:
21.3		 4i22A-4wboA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 VAL A 201
ALA A 214
ASP A 271
ASP A 314
LYS A 316
ASN A 319
ASP A 332
 None
ANW  A 601 (-3.4A)
None
None
None
None
None
 0.63A 4i41A-4wboA:
27.5		 4i41A-4wboA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 11 VAL A 201
ALA A 214
LYS A 216
ASP A 271
GLU A 318
LEU A 321
ASP A 332
 None
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 (-4.9A)
None
 0.84A 4iaaA-4wboA:
27.4		 4iaaA-4wboA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 GLY A 194
VAL A 201
ALA A 214
LYS A 216
LEU A 250
LEU A 262
GLY A 270
LEU A 321
 None
None
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.60A 4ifgA-4wboA:
22.7		 4ifgA-4wboA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
VAL A 248
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.88A 4mxxB-4wboA:
22.8		 4mxxB-4wboA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
VAL A 201
ALA A 214
GLU A 235
VAL A 248
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.85A 4mxyA-4wboA:
24.6		 4mxyA-4wboA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 LEU A 193
VAL A 201
ALA A 214
GLU A 235
VAL A 248
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.85A 4mxzA-4wboA:
24.6		 4mxzA-4wboA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 11 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
ASN A 319
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-4.9A)
 0.78A 4o0sA-4wboA:
31.0		 4o0sA-4wboA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		4 / 6 VAL A 201
ALA A 214
LYS A 216
LEU A 321
 None
ANW  A 601 (-3.4A)
None
ANW  A 601 (-4.9A)
 0.70A 4o0uA-4wboA:
9.5		 4o0uA-4wboA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
GLY A 194
GLY A 199
VAL A 201
ALA A 214
VAL A 248
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
None
ANW  A 601 (-3.4A)
None
ANW  A 601 (-4.9A)
 0.61A 4otiA-4wboA:
32.4		 4otiA-4wboA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
VAL A 201
LYS A 216
VAL A 248
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.92A 4otwA-4wboA:
21.0		 4otwA-4wboA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		9 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
MET A 267
GLY A 270
ASN A 319
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
None
ANW  A 601 (-4.9A)
None
 0.69A 4twpA-4wboA:
24.8		 4twpA-4wboA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		9 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
MET A 267
GLY A 270
ASN A 319
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
None
ANW  A 601 (-4.9A)
None
 0.78A 4twpB-4wboA:
25.2		 4twpB-4wboA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 6 LEU A 193
LYS A 216
ILE A 247
ARG A 313
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
None
 1.01A 4tyjA-4wboA:
22.6		 4tyjA-4wboA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 6 LEU A 193
VAL A 201
LYS A 216
ILE A 247
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
None
 0.78A 4tyjA-4wboA:
22.6		 4tyjA-4wboA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 10 LEU A 193
VAL A 201
GLU A 235
ILE A 247
VAL A 248
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
None
None
 0.81A 4u0iA-4wboA:
22.4		 4u0iA-4wboA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		9 / 11 LEU A 193
GLY A 196
VAL A 201
ALA A 214
MET A 267
GLY A 270
ASN A 319
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
None
ANW  A 601 (-4.9A)
None
 0.67A 4u5jA-4wboA:
25.2		 4u5jA-4wboA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 9 LEU A 193
VAL A 201
ALA A 214
MET A 267
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.82A 4u5jB-4wboA:
24.7		 4u5jB-4wboA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 9 LEU A 193
VAL A 201
LYS A 216
ARG A 313
LEU A 321
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
ANW  A 601 (-4.9A)
None
 0.88A 4v01A-4wboA:
22.1		 4v01A-4wboA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 9 LEU A 193
VAL A 201
LYS A 216
ARG A 313
LEU A 321
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
ANW  A 601 (-4.9A)
None
 0.92A 4v01B-4wboA:
22.4		 4v01B-4wboA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 11 LEU A 193
ALA A 214
LYS A 216
GLY A 270
ASN A 319
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
None
ANW  A 601 (-4.9A)
 1.10A 4wa9A-4wboA:
21.6		 4wa9A-4wboA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 11 LEU A 193
ALA A 214
MET A 267
GLY A 270
ASN A 319
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
None
ANW  A 601 (-4.9A)
 0.79A 4wa9A-4wboA:
21.6		 4wa9A-4wboA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 8 LEU A 193
ALA A 214
MET A 264
ILE A 266
ASN A 268
LEU A 321
SER A 331
ALA A 478
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
None
ANW  A 601 (-4.9A)
ANW  A 601 ( 4.0A)
ANW  A 601 (-3.5A)
 0.14A 4wboB-4wboA:
55.8		 4wboB-4wboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 6 ARG A 191
ALA A 214
MET A 264
MET A 267
LEU A 321
 ANW  A 601 ( 4.9A)
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
ANW  A 601 (-4.9A)
 0.62A 4wboC-4wboA:
38.3		 4wboC-4wboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 6 LEU A 193
ALA A 214
MET A 264
MET A 267
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
ANW  A 601 (-4.9A)
 0.18A 4wboC-4wboA:
38.3		 4wboC-4wboA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
ALA A 214
LYS A 216
GLU A 235
LEU A 262
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.69A 4wkqA-4wboA:
21.2		 4wkqA-4wboA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.69A 4xeyA-4wboA:
25.0		 4xeyA-4wboA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
ALA A 214
GLU A 235
VAL A 248
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.67A 4xliA-4wboA:
25.9		 4xliA-4wboA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
ALA A 214
LYS A 216
GLU A 235
MET A 267
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.68A 4xliA-4wboA:
25.9		 4xliA-4wboA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 9 LEU A 193
VAL A 201
ALA A 214
MET A 267
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.58A 5aaaA-4wboA:
23.6		 5aaaA-4wboA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 10 LEU A 193
VAL A 201
ALA A 214
LYS A 216
MET A 267
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.63A 5aabA-4wboA:
23.3		 5aabA-4wboA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 10 LEU A 193
VAL A 201
ALA A 214
LYS A 216
MET A 267
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.72A 5aacA-4wboA:
23.2		 5aacA-4wboA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 12 GLY A 194
VAL A 201
ALA A 214
VAL A 248
ASP A 271
LEU A 321
 None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-4.9A)
 0.67A 5l2iA-4wboA:
22.2		 5l2iA-4wboA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 11 LEU A 193
GLY A 194
VAL A 201
ALA A 214
VAL A 248
GLU A 318
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-4.9A)
 0.64A 5lvnA-4wboA:
29.2		 5lvnA-4wboA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 9 GLY A 194
VAL A 201
ALA A 214
MET A 264
MET A 267
 None
None
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
 0.59A 5lw1B-4wboA:
16.6		 5lw1B-4wboA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 10 GLY A 194
VAL A 201
ALA A 214
MET A 264
MET A 267
 None
None
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
 0.62A 5lw1E-4wboA:
17.8		 5lw1E-4wboA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 9 GLY A 194
VAL A 201
ALA A 214
MET A 264
MET A 267
 None
None
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
 0.45A 5lw1H-4wboA:
18.3		 5lw1H-4wboA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 10 LEU A 193
VAL A 201
ALA A 214
VAL A 248
MET A 264
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
ANW  A 601 (-3.2A)
ANW  A 601 (-4.9A)
 0.51A 5n3hA-4wboA:
36.9		 5n3hA-4wboA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		4 / 8 ALA A 214
GLU A 235
LEU A 321
ASP A 332
 ANW  A 601 (-3.4A)
None
ANW  A 601 (-4.9A)
None
 0.53A 5owrA-4wboA:
24.6		 5owrA-4wboA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		4 / 8 ILE A 238
LEU A 239
MET A 264
LEU A 262
 None
None
ANW  A 601 (-3.2A)
None
 0.92A 5u4sB-4wboA:
undetectable		 5u4sB-4wboA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
GLY A 269
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
 0.77A 5vcyA-4wboA:
24.9		 5vcyA-4wboA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		6 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 262
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
 0.73A 5vcyA-4wboA:
24.9		 5vcyA-4wboA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		5 / 9 LEU A 193
ALA A 214
VAL A 248
MET A 264
GLY A 270
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
ANW  A 601 (-3.2A)
ANW  A 601 ( 4.5A)
 0.71A 5w5vA-4wboA:
14.1		 5w5vA-4wboA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 ARG A 191
LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
GLY A 270
LEU A 321
 ANW  A 601 ( 4.9A)
ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.81A 5y7zA-4wboA:
25.5		 5y7zA-4wboA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		8 / 12 ARG A 191
LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
GLY A 270
LEU A 321
 ANW  A 601 ( 4.9A)
ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.81A 5y7zA-4wboA:
25.5		 5y7zA-4wboA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
LEU A 262
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-4.9A)
 0.70A 5yu9A-4wboA:
21.2		 5yu9A-4wboA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		3 / 3 LYS A 216
LEU A 321
ASP A 332
 None
ANW  A 601 (-4.9A)
None
 0.89A 5zv2A-4wboA:
22.1		 5zv2A-4wboA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		7 / 12 VAL A 201
ALA A 214
LYS A 216
MET A 267
GLY A 270
LEU A 321
SER A 331
 None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
ANW  A 601 ( 4.0A)
 0.80A 6fnmA-4wboA:
23.6		 6fnmA-4wboA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4wbo RHODOPSIN KINASE
(Bos
taurus) 		4 / 5 LEU A 193
ILE A 238
MET A 267
GLY A 270
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 ( 4.5A)
 0.78A 6hd6A-4wboA:
16.1		 6hd6A-4wboA:
12.96