SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'AN2'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 12 LEU A 193
VAL A 201
ALA A 214
GLU A 235
GLY A 270
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
None
AN2  A 601 (-3.0A)
 1.05A 1iepB-4yhjA:
19.8		 1iepB-4yhjA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 12 LEU A 193
ALA A 214
LYS A 216
GLU A 235
LEU A 262
MET A 267
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
None
 0.62A 1m17A-4yhjA:
23.7		 1m17A-4yhjA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		9 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 239
VAL A 248
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
None
AN2  A 601 (-3.0A)
 0.90A 1t46A-4yhjA:
20.3		 1t46A-4yhjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		8 / 12 VAL A 201
LYS A 216
GLU A 235
LEU A 239
VAL A 248
GLY A 270
LEU A 319
ASP A 330
 AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
None
None
None
AN2  A 601 (-3.0A)
 1.00A 1t46A-4yhjA:
20.3		 1t46A-4yhjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		5 / 9 LEU A 193
VAL A 201
LEU A 250
LEU A 262
MET A 267
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
None
None
None
 0.82A 1xkkA-4yhjA:
20.2		 1xkkA-4yhjA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		5 / 9 VAL A 201
LYS A 216
LEU A 250
LEU A 262
MET A 267
 AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
None
 0.81A 1xkkA-4yhjA:
20.2		 1xkkA-4yhjA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		5 / 10 LEU A 193
ALA A 214
LEU A 264
ASP A 271
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 4.8A)
None
None
 0.66A 1yi4A-4yhjA:
25.1		 1yi4A-4yhjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 12 LEU A 193
ALA A 214
LYS A 216
GLU A 235
LEU A 262
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
 0.68A 2itoA-4yhjA:
22.7		 2itoA-4yhjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		8 / 12 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 262
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
 0.80A 2ityA-4yhjA:
22.4		 2ityA-4yhjA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 12 LEU A 193
GLY A 194
VAL A 201
LYS A 216
LEU A 239
LEU A 262
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
None
 0.62A 2ivuA-4yhjA:
23.4		 2ivuA-4yhjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 3ied HEAT SHOCK PROTEIN
(Plasmodium
falciparum) 		4 / 7 LEU A 303
ILE A 301
ASN A 133
PHE A 248
 None
None
AN2  A 401 (-3.0A)
None
 0.88A 2opxA-3iedA:
undetectable		 2opxA-3iedA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Drosophila
melanogaster) 		5 / 12 ALA A 406
THR A 572
ARG A 423
LEU A 469
GLN A 431
 None
None
AN2  A1788 (-2.8A)
None
None
 1.36A 2rctA-4bwpA:
undetectable		 2rctA-4bwpA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 12 GLY A 194
VAL A 201
ALA A 214
LEU A 264
MET A 267
ASP A 330
 AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 4.8A)
None
AN2  A 601 (-3.0A)
 0.61A 2wgjA-4yhjA:
16.8		 2wgjA-4yhjA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 9 LEU A 193
VAL A 201
ALA A 214
LEU A 264
MET A 267
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 4.8A)
None
None
AN2  A 601 (-3.0A)
 0.56A 2xp2A-4yhjA:
21.4		 2xp2A-4yhjA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 9 LEU A 193
VAL A 201
MET A 267
GLY A 270
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
None
None
None
AN2  A 601 (-3.0A)
 0.75A 2xp2A-4yhjA:
21.4		 2xp2A-4yhjA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 12 LEU A 193
ALA A 214
LYS A 216
GLU A 235
VAL A 248
MET A 267
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
None
 0.81A 2zvaA-4yhjA:
22.9		 2zvaA-4yhjA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 10 ARG A 191
LEU A 193
ALA A 214
LYS A 216
VAL A 248
LEU A 264
LEU A 319
 None
AN2  A 601 ( 4.2A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
AN2  A 601 ( 4.8A)
None
 1.07A 3aoxA-4yhjA:
20.8		 3aoxA-4yhjA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 10 ARG A 191
LEU A 193
LYS A 216
VAL A 248
LEU A 264
GLY A 270
LEU A 319
 None
AN2  A 601 ( 4.2A)
AN2  A 601 ( 3.9A)
None
AN2  A 601 ( 4.8A)
None
None
 1.22A 3aoxA-4yhjA:
20.8		 3aoxA-4yhjA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 10 LEU A 193
ALA A 214
LYS A 216
VAL A 248
LEU A 264
MET A 267
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
AN2  A 601 ( 4.8A)
None
None
 0.62A 3aoxA-4yhjA:
20.8		 3aoxA-4yhjA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 10 LEU A 193
LYS A 216
VAL A 248
LEU A 264
MET A 267
GLY A 270
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 ( 3.9A)
None
AN2  A 601 ( 4.8A)
None
None
None
 0.84A 3aoxA-4yhjA:
20.8		 3aoxA-4yhjA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 12 LEU A 193
GLY A 194
ALA A 214
LYS A 216
VAL A 248
GLY A 270
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
 0.67A 3c7qA-4yhjA:
16.4		 3c7qA-4yhjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 12 VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 239
MET A 267
 AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
 1.46A 3hegA-4yhjA:
21.5		 3hegA-4yhjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		5 / 12 LEU A 279
GLY A 269
GLY A 270
LEU A 193
ALA A 472
 None
None
None
AN2  A 601 ( 4.2A)
None
 1.04A 3i5uA-4yhjA:
undetectable		 3i5uA-4yhjA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		5 / 12 LEU A 279
GLY A 269
GLY A 270
LEU A 193
ALA A 472
 None
None
None
AN2  A 601 ( 4.2A)
None
 1.04A 3i5uB-4yhjA:
undetectable		 3i5uB-4yhjA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		5 / 8 ALA A 214
LYS A 216
GLU A 235
LEU A 262
MET A 267
 AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
 0.63A 3lfaA-4yhjA:
20.1		 3lfaA-4yhjA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 11 ALA A 214
LYS A 216
VAL A 248
MET A 267
LEU A 319
SER A 329
 AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
AN2  A 601 ( 4.5A)
 0.80A 3miyA-4yhjA:
20.3		 3miyA-4yhjA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		5 / 9 ALA A 214
LYS A 216
MET A 267
LEU A 319
SER A 329
 AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
AN2  A 601 ( 4.5A)
 0.71A 3miyB-4yhjA:
20.3		 3miyB-4yhjA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
LEU A 262
MET A 267
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
 0.87A 3ug2A-4yhjA:
22.6		 3ug2A-4yhjA:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		3 / 3 LEU A 264
MET A 267
ASP A 271
 AN2  A 601 ( 4.8A)
None
None
 0.34A 3v5wA-4yhjA:
15.6		 3v5wA-4yhjA:
33.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		4 / 5 ILE A 238
VAL A 248
LEU A 319
ASP A 330
 None
None
None
AN2  A 601 (-3.0A)
 1.10A 3wzdA-4yhjA:
16.6		 3wzdA-4yhjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		4 / 8 VAL A 247
VAL A 248
ILE A 328
ASP A 330
 None
None
None
AN2  A 601 (-3.0A)
 0.51A 3wzeA-4yhjA:
20.4		 3wzeA-4yhjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		8 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
VAL A 248
GLY A 270
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
None
 0.98A 4ag8A-4yhjA:
20.2		 4ag8A-4yhjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 9 LEU A 193
VAL A 201
ALA A 214
LEU A 264
MET A 267
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 4.8A)
None
None
AN2  A 601 (-3.0A)
 0.58A 4anqA-4yhjA:
21.3		 4anqA-4yhjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 9 LEU A 193
VAL A 201
MET A 267
GLY A 270
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
None
None
None
AN2  A 601 (-3.0A)
 0.77A 4anqA-4yhjA:
21.3		 4anqA-4yhjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 9 LEU A 193
VAL A 201
ALA A 214
MET A 267
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
None
AN2  A 601 (-3.0A)
 0.52A 4ansA-4yhjA:
21.3		 4ansA-4yhjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		8 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 239
GLY A 270
LEU A 303
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
None
None
 0.97A 4asdA-4yhjA:
20.3		 4asdA-4yhjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3ied HEAT SHOCK PROTEIN
(Plasmodium
falciparum) 		4 / 8 SER A 210
MET A 207
ILE A 213
GLU A 211
 None
AN2  A 401 (-3.6A)
None
None
 1.10A 4cx7A-3iedA:
undetectable
4cx7B-3iedA:
undetectable		 4cx7A-3iedA:
19.54
4cx7B-3iedA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3ied HEAT SHOCK PROTEIN
(Plasmodium
falciparum) 		4 / 8 SER A 210
MET A 207
ILE A 213
GLU A 211
 None
AN2  A 401 (-3.6A)
None
None
 1.18A 4cx7C-3iedA:
undetectable
4cx7D-3iedA:
undetectable		 4cx7C-3iedA:
19.54
4cx7D-3iedA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		8 / 12 VAL A 201
ALA A 214
ASP A 271
ASP A 312
LYS A 314
ASN A 317
LEU A 319
ASP A 330
 AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
None
None
None
None
AN2  A 601 (-3.0A)
 0.91A 4i41A-4yhjA:
25.0		 4i41A-4yhjA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 11 LYS A 216
LEU A 264
ASP A 271
GLU A 316
LEU A 319
ASP A 330
 AN2  A 601 ( 3.9A)
AN2  A 601 ( 4.8A)
None
None
None
AN2  A 601 (-3.0A)
 1.15A 4iaaA-4yhjA:
24.9		 4iaaA-4yhjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 11 VAL A 201
ALA A 214
LYS A 216
LEU A 264
ASP A 271
LEU A 319
ASP A 330
 AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
AN2  A 601 ( 4.8A)
None
None
AN2  A 601 (-3.0A)
 0.85A 4iaaA-4yhjA:
24.9		 4iaaA-4yhjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 12 GLY A 194
VAL A 201
ALA A 214
LEU A 250
LEU A 262
GLY A 270
LEU A 319
 AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
None
None
None
 0.47A 4ifgA-4yhjA:
21.3		 4ifgA-4yhjA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 11 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
ASN A 317
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
 0.80A 4o0sA-4yhjA:
28.5		 4o0sA-4yhjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		4 / 6 LEU A 193
GLY A 194
VAL A 201
ALA A 214
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
 0.22A 4o0wA-4yhjA:
27.4		 4o0wA-4yhjA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 12 LEU A 193
GLY A 194
GLY A 199
VAL A 201
ALA A 214
VAL A 248
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
None
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
None
 0.52A 4otiA-4yhjA:
31.6		 4otiA-4yhjA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 12 VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 319
ASP A 330
 AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
AN2  A 601 (-3.0A)
 0.80A 4r7iA-4yhjA:
20.1		 4r7iA-4yhjA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		5 / 6 LEU A 193
VAL A 201
LYS A 216
ILE A 328
ILE A 318
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
 1.41A 4tyjA-4yhjA:
20.4		 4tyjA-4yhjA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 9 LEU A 193
VAL A 201
ALA A 214
MET A 267
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
None
AN2  A 601 (-3.0A)
 0.68A 4u5jB-4yhjA:
22.0		 4u5jB-4yhjA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 8 LEU A 193
ALA A 214
ILE A 266
ASN A 268
LEU A 319
SER A 329
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.6A)
None
None
None
AN2  A 601 ( 4.5A)
 0.57A 4wboB-4yhjA:
44.8		 4wboB-4yhjA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		4 / 6 LEU A 193
ALA A 214
MET A 267
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.6A)
None
None
 0.37A 4wboC-4yhjA:
44.1		 4wboC-4yhjA:
44.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 9 LEU A 193
VAL A 201
ALA A 214
LEU A 264
MET A 267
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 4.8A)
None
None
AN2  A 601 (-3.0A)
 0.67A 5aaaA-4yhjA:
21.7		 5aaaA-4yhjA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 9 LEU A 193
VAL A 201
MET A 267
GLY A 270
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
None
None
None
AN2  A 601 (-3.0A)
 0.85A 5aaaA-4yhjA:
21.7		 5aaaA-4yhjA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		8 / 10 LEU A 193
VAL A 201
ALA A 214
LYS A 216
LEU A 264
MET A 267
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
AN2  A 601 ( 4.8A)
None
None
AN2  A 601 (-3.0A)
 0.87A 5aabA-4yhjA:
21.3		 5aabA-4yhjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 10 LEU A 193
VAL A 201
LYS A 216
MET A 267
GLY A 270
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
None
AN2  A 601 (-3.0A)
 0.97A 5aabA-4yhjA:
21.3		 5aabA-4yhjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		8 / 10 LEU A 193
VAL A 201
ALA A 214
LYS A 216
LEU A 264
MET A 267
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
AN2  A 601 ( 4.8A)
None
None
AN2  A 601 (-3.0A)
 0.80A 5aacA-4yhjA:
21.3		 5aacA-4yhjA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 10 LEU A 193
VAL A 201
LYS A 216
MET A 267
GLY A 270
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
None
AN2  A 601 (-3.0A)
 0.95A 5aacA-4yhjA:
21.3		 5aacA-4yhjA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 12 GLY A 194
VAL A 201
ALA A 214
VAL A 248
ASP A 271
LEU A 319
 AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
None
None
 0.71A 5l2iA-4yhjA:
9.2		 5l2iA-4yhjA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 11 LEU A 193
GLY A 194
VAL A 201
ALA A 214
VAL A 248
LEU A 264
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
AN2  A 601 ( 4.8A)
None
 0.43A 5lvnA-4yhjA:
32.3		 5lvnA-4yhjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 12 GLY A 194
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 264
GLY A 270
 AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
AN2  A 601 ( 4.8A)
None
 0.46A 5mafA-4yhjA:
27.1		 5mafA-4yhjA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 12 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 262
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
 0.62A 5vcyA-4yhjA:
22.7		 5vcyA-4yhjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		7 / 12 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
LEU A 262
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
 0.87A 5yu9A-4yhjA:
19.6		 5yu9A-4yhjA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens) 		6 / 12 GLY A 194
VAL A 201
ALA A 214
LYS A 216
LEU A 262
LEU A 319
 AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
 0.85A 5yu9B-4yhjA:
19.7		 5yu9B-4yhjA:
9.45